Protein Alignment Kat60 and KATNAL1

DIOPT Version :10

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_115492.1
• Gene: KATNAL1 / 84056
• HGNCID: 28361
• Length: 490
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 292/551 - (52%)
• Similarity: 363/551 - (65%)
• Gaps: 72/551 - (13%)

  Fly    62 EICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAI 126
            |||:|||..|:.||.|||||:.:||:|:...:.|..::..||..||||..:.|::.:|:.::|:|
Human     5 EICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSI 69

  Fly   127 QRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDI----WTPPPKDPDVWGPPKPP 187
            ..||:...:|                            || ||.    ...|.:||.||.||.|
Human    70 VSTLESFKID----------------------------KP-PDFPVSCQDEPFRDPAVWPPPVP- 104

  Fly   188 PTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRA 252
                 ...||.|..||   ..:..||               .|.......|..|.|.|...   :
Human   105 -----AEHRAPPQIRR---PNREVRP---------------LRKEMAGVGARGPVGRAHPI---S 143

  Fly   253 GGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDIL 317
            ...|.|||     ||.|..|.|.:.....:.::|   |:..|..||....: :.:||:.|||||:
Human   144 KSEKPSTS-----RDKDYRARGRDDKGRKNMQDG---ASDGEMPKFDGAGY-DKDLVEALERDIV 199

  Fly   318 QKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATE 382
            .::|.:.|.|||||.:||:||.|||||||.|||:|||||||||||||||||||||||||||||||
Human   200 SRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATE 264

  Fly   383 CGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVK 447
            ||||||||||:||||||||||||:|||||||||||||:|||||||||:|||||:..|||||||||
Human   265 CGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVK 329

  Fly   448 SELLVQMDGVGG---GEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINL 509
            ||||:|||||||   .::.:|:||||||||||||||||||||||||||||||:.:||..||||||
Human   330 SELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINL 394

  Fly   510 REVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVSNK 574
            |||::|..:.|..:|.:::||||||||||||:||:|:|||:|.||:||:||.|:.||:.:||:..
Human   395 REVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKG 459

  Fly   575 DFNEAMSRCNKSVSRADLDKYEKWMREFGSS 605
            ||..|:.:..||||.|||:||||||.||||:
Human   460 DFELALKKIAKSVSAADLEKYEKWMVEFGSA 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	Kp60-NTD	62..129	CDD:439297	28/66 (42%)
		PHA03291	<167..>253	CDD:223033	22/89 (25%)
		SpoVK	219..566	CDD:440232	218/349 (62%)
		RecA-like_KTNA1	327..493	CDD:410930	145/168 (86%)
		Vps4_C	<570..603	CDD:462762	19/32 (59%)
KATNAL1	NP_115492.1	Kp60-NTD	4..72	CDD:439297	28/66 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..184		33/123 (27%)
		RecA-like_KTNA1	209..378	CDD:410930	145/168 (86%)
		AAA_lid_3	402..446	CDD:465537	26/43 (60%)
		Vps4_C	<450..488	CDD:462762	21/37 (57%)