DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and KATNAL1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001014402.1	Gene:	KATNAL1 / 84056	HGNCID:	28361	Length:	490	Species:	Homo sapiens

Alignment Length:	551	Identity:	292/551 - (52%)
Similarity:	363/551 - (65%)	Gaps:	72/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAI 126
            |||:|||..|:.||.|||||:.:||:|:...:.|..::..||..||||..:.|::.:|:.::|:|
Human     5 EICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSI 69

  Fly   127 QRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDI----WTPPPKDPDVWGPPKPP 187
            ..||:...:|                            || ||.    ...|.:||.||.||.|
Human    70 VSTLESFKID----------------------------KP-PDFPVSCQDEPFRDPAVWPPPVP- 104

  Fly   188 PTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRA 252
                 ...||.|..||   ..:..||               .|.......|..|.|.|...   :
Human   105 -----AEHRAPPQIRR---PNREVRP---------------LRKEMAGVGARGPVGRAHPI---S 143

  Fly   253 GGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDIL 317
            ...|.|||     ||.|..|.|.:.....:.::|   |:..|..||....: :.:||:.|||||:
Human   144 KSEKPSTS-----RDKDYRARGRDDKGRKNMQDG---ASDGEMPKFDGAGY-DKDLVEALERDIV 199

  Fly   318 QKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATE 382
            .::|.:.|.|||||.:||:||.|||||||.|||:|||||||||||||||||||||||||||||||
Human   200 SRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATE 264

  Fly   383 CGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVK 447
            ||||||||||:||||||||||||:|||||||||||||:|||||||||:|||||:..|||||||||
Human   265 CGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVK 329

  Fly   448 SELLVQMDGVGG---GEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINL 509
            ||||:|||||||   .::.:|:||||||||||||||||||||||||||||||:.:||..||||||
Human   330 SELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINL 394

  Fly   510 REVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVSNK 574
            |||::|..:.|..:|.:::||||||||||||:||:|:|||:|.||:||:||.|:.||:.:||:..
Human   395 REVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKG 459

  Fly   575 DFNEAMSRCNKSVSRADLDKYEKWMREFGSS 605
            ||..|:.:..||||.|||:||||||.||||:
Human   460 DFELALKKIAKSVSAADLEKYEKWMVEFGSA 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	22/83 (27%)
		P-loop_NTPase	325..>381	CDD:304359	48/55 (87%)
		AAA	358..496	CDD:214640	123/140 (88%)
		AAA	362..495	CDD:278434	118/135 (87%)
		Vps4_C	<570..603	CDD:286426	19/32 (59%)
KATNAL1	NP_001014402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..184		33/123 (27%)
KATNAL1	NP_001014402.1	SpoVK	<188..483	CDD:223540	216/294 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157806
Domainoid	1	1.000	241	1.000	Domainoid score	I2243
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12942
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1255
Isobase	1	0.950	-	0	Normalized mean entropy	S1180
OMA	1	1.010	-	-		QHG59967
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm40614
orthoMCL	1	0.900	-	-		OOG6_102233
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5542
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750