Protein Alignment Kat60 and KATNAL2

DIOPT Version :10

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001340828.1
• Gene: KATNAL2 / 83473
• HGNCID: 25387
• Length: 564
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 173/457 - (37%)
• Similarity: 253/457 - (55%)
• Gaps: 75/457 - (16%)

  Fly   212 RPSSTIPQSTARNGPASTRNSRNSTSATAPS-----GGARTTNGRAGGRK-LSTSNTNEARDDDS 270
            :.|.|...:..:.....||...|.:....|.     ..::||.|:.|..| |:..:.|:...|::
Human   118 KSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRSKTTAGKTGDTKSLNKEHPNQEVVDNT 182

  Fly   271 TAAGNNGGA--------AGDGENGDPQAAQ-----------------------------EEERKF 298
            .....|.|.        :|: ||..|:..|                             ..||..
Human   183 RLESANFGLHISRIRKDSGE-ENAHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLL 246

  Fly   299 QP-------NNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIR 356
            :|       |:.:. ||..::.|||...:|.::|:||..|..||:|::||||.|:..|..|.||.
Human   247 KPLSAFIGMNSEMR-ELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGIL 310

  Fly   357 RPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPST 421
            .||||:|:.||||||||:|||||||||.|||||:|::|:.||:||:|||:||:|||:||::||||
Human   311 SPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPST 375

  Fly   422 IFIDEIDSLCSRRGSES--EHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALR 484
            ||:||::|:.|:||:.|  |||.|.|:|:||||||||:...|:   :|.||||:|.||::|.|:.
Human   376 IFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSED---LVFVLAASNLPWELDCAML 437

  Fly   485 RRLEKRIYIPLPSDEGREALLKINL------REVKVDDSVDLTYVANELKGYSGADITNVCREAS 543
            |||||||.:.|||.|.|:|::...|      |.:::...::.:.::.|.:||||:||..|||||:
Human   438 RRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAA 502

  Fly   544 MMSMRRKIAGLTPEQIRQLATEEVDLP------VSNKDFNEAMSRCNKSVSRADLDKYEKWMREF 602
            |..:|:....|...|     :|..|||      |:..||.:.::....|.... ..:|..|.|||
Human   503 MRPVRKIFDALENHQ-----SESSDLPRIQLDIVTTADFLDVLTHTKPSAKNL-AQRYSDWQREF 561

  Fly   603 GS 604
            .|
Human   562 ES 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	Kp60-NTD	62..129	CDD:439297
		PHA03291	<167..>253	CDD:223033	9/45 (20%)
		SpoVK	219..566	CDD:440232	157/404 (39%)
		RecA-like_KTNA1	327..493	CDD:410930	103/167 (62%)
		Vps4_C	<570..603	CDD:462762	9/38 (24%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913
		RPT1	212..548	CDD:440835	146/344 (42%)
		RecA-like_VPS4-like	282..446	CDD:410917	102/166 (61%)