DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and FIGNL1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001036227.1	Gene:	FIGNL1 / 63979	HGNCID:	13286	Length:	674	Species:	Homo sapiens

Alignment Length:	428	Identity:	160/428 - (37%)
Similarity:	231/428 - (53%)	Gaps:	65/428 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 PNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNG-----------RA 252
            |....:.|..:.::....:.|....:.|  .|.|.:|......|.||..:.|           :.
Human   286 PKEDSSLPTFKTAKEQLWVDQQKKYHQP--QRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQD 348

  Fly   253 GGRKLSTSNTNEARDDDSTAAGNNGG------AAGDGENGDPQAAQEEERKFQPNNHIEAELVDI 311
            ||.:                   |||      .||..|...|    .:||.    .::|.:::::
Human   349 GGEQ-------------------NGGMQCKPYGAGPTEPAHP----VDERL----KNLEPKMIEL 386

  Fly   312 LERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLA 376
            :..:|:...|.|.|.|||.:..||..::|.||.|||.||.|.|:|.|.||:|:.||||||||::.
Human   387 IMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIG 451

  Fly   377 KAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHE 441
            |.:|::.|.|||::|:::||||:.||.|||||.||.:||...|:.|||||||||.|:|| :.|||
Human   452 KCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG-DGEHE 515

  Fly   442 ASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLK 506
            :|||:|:|.|||:||.....|..  ::|:.|||.|.:||||.||||.||:|||||....|:.::
Human   516 SSRRIKTEFLVQLDGATTSSEDR--ILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIV- 577

  Fly   507 INL--REVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMR----RKIAGLTPEQIRQLATE 565
            |||  :|.......::..:..:...:||||:|.:|||||:..:|    ..||.:||:|:|
Human   578 INLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVR----- 637

  Fly   566 EVDLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFG 603
                |::..||..|......|||..||:.||.|.:.||
Human   638 ----PIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	7/43 (16%)
		P-loop_NTPase	325..>381	CDD:304359	30/55 (55%)
		AAA	358..496	CDD:214640	79/137 (58%)
		AAA	362..495	CDD:278434	75/132 (57%)
		Vps4_C	<570..603	CDD:286426	12/32 (38%)
FIGNL1	NP_001036227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..179
		Necessary and sufficient for interaction with RAD51. /evidence=ECO:0000305\|PubMed:23754376	295..344		9/50 (18%)
		SpoVK	<374..668	CDD:223540	138/310 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840