DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and PSMC5

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_024306608.1	Gene:	PSMC5 / 5705	HGNCID:	9552	Length:	433	Species:	Homo sapiens

Alignment Length:	293	Identity:	111/293 - (37%)
Similarity:	163/293 - (55%)	Gaps:	25/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 KFQPNNHIEAELVD-ILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFK--GIRRP 358
            |..||.      || ::...:::|.|...:..|..|....:.::|.:.||:..|:.|:  ||.:|
Human   152 KILPNK------VDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP 210

  Fly   359 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIF 423
             ||||:.||||||||:||:|||.....||..||.:.|..|:.||..:|||.||.|||.:|||.||
Human   211 -KGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIF 274

  Fly   424 IDEIDSLCSRR---GSESEHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRR 485
            :|||||:.|.|   ||..:.|. :|...|||.|:||.    |..|.:.|:.|||....:|.||.|
Human   275 MDEIDSIGSSRLEGGSGGDSEV-QRTMLELLNQLDGF----EATKNIKVIMATNRIDILDSALLR 334

  Fly   486 --RLEKRIYIPLPSDEGREALLKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMR 548
              |::::|..|.|::|.|..:|||:.|::.:...::|..:|..:.|.|||::..||.||.|.::|
Human   335 PGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALR 399

  Fly   549 RKIAGLTPEQIRQLATEEVDLPVSNKDFNEAMS 581
            .:...:|.|.......:     |..||..:.||
Human   400 ERRVHVTQEDFEMAVAK-----VMQKDSEKNMS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	26/57 (46%)
		AAA	358..496	CDD:214640	69/142 (49%)
		AAA	362..495	CDD:278434	65/137 (47%)
		Vps4_C	<570..603	CDD:286426	5/12 (42%)
PSMC5	XP_024306608.1	RPT1	4..431	CDD:224143	111/293 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810