DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and fignl2

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001201837.1	Gene:	fignl2 / 561837	ZFINID:	ZDB-GENE-090313-189	Length:	684	Species:	Danio rerio

Alignment Length:	500	Identity:	120/500 - (24%)
Similarity:	211/500 - (42%)	Gaps:	98/500 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 HQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPPPTTQAVGRRAAPNNRR----TTPAT 208
            ||      |...||......|.|.:|.|..|.|.|.......:...|.....:.:|    .|...
Zfish   236 HQ------TGLAPSYTHPTAPYIPSPLPSRPTVVGGSYGYQNSSVGGSEPGGSLKRKAFEMTLDE 294

  Fly   209 QNS-----RPSSTIPQSTARNGPASTRNSRNS---TSATAPSG--GARTTN---------GRAGG 254
            ::|     |..|..|..|..:.|....:...:   |.:|.|.|  .::.::         |:..|
Zfish   295 EDSDSSRYRKYSYDPMKTGGDSPYGVTDKAGNGFGTGSTDPQGFKPSKPSSQSSLEGDEVGKYSG 359

  Fly   255 RKLSTSNTNEARDDDSTAA---GNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDI 316
            .|...|.|..|..|.|..|   |.||||    |.|..|  ...:::..|...||..:::::.|::
Zfish   360 LKPLVSPTYGAAGDYSPPAAMTGENGGA----EQGFSQ--NRSQKRSDPMKSIEPRMLELVSREL 418

  Fly   317 LQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVAT 381
            ....|.:.|:::|.....|..|||.::.|:|.|:  ..|..| |.:|:.||.|.|||.||:::::
Zfish   419 QDCSPAMLWTELAGNCHIKAALEEDLLWPVLRPN--PAIHPP-KTILLFGPQGGGKTTLARSLSS 480

  Fly   382 ECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRV 446
            :.|.:|:.:|.|||.||.:||:|:::..||.:|....|:.:.:.|::::        |.|..|:
Zfish   481 QIGASFYRLSCATLASKLKGEAEQLLLTLFSVATARQPAMVLLSEVEAI--------EEEGLRQ- 536

  Fly   447 KSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALL------ 505
              :|..|::.:  ...|:...:|:..|..|..|.::|.|...||.:|.||....|..:|
Zfish   537 --QLQAQLEKI--QHNQSNQFLVVCTTRRPDLIKDSLLRCFSKRYHIGLPDGNTRRHVLLQALAP 597

  Fly   506 ---KINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEV 567
               .::.||        |:.|....:|:|..::..:|::|        :|.         |:...
Zfish   598 QGCSLSERE--------LSAVLQRSEGFSVWELLQLCQQA--------LAS---------ASASA 637

  Fly   568 DLPVSN----------KDFNEAMSRCNKSVSRADLDKYEKWMREF 602
            .:|:.:          :||..|..:.....:..:||...:|.:.:
Zfish   638 SVPLHSLPASLSSPTLQDFENAFCKVRPHSTPKELDTCMEWSKVY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	19/91 (21%)
		P-loop_NTPase	325..>381	CDD:304359	21/55 (38%)
		AAA	358..496	CDD:214640	42/137 (31%)
		AAA	362..495	CDD:278434	40/132 (30%)
		Vps4_C	<570..603	CDD:286426	7/42 (17%)
fignl2	NP_001201837.1	AAA	457..583	CDD:214640	43/139 (31%)
fignl2	NP_001201837.1	AAA	461..581	CDD:278434	40/132 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840