DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and katna1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001018440.1	Gene:	katna1 / 553631	ZFINID:	ZDB-GENE-050522-514	Length:	485	Species:	Danio rerio

Alignment Length:	545	Identity:	274/545 - (50%)
Similarity:	357/545 - (65%)	Gaps:	67/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAI 126
            ||.||.||||:.||.|||.||.:.|:|:...:.:.|.:..|...:.||..:.|:|::|..:::.|
Zfish     5 EINENVKLAREYALLGNYSSAVVCYQGVLEQIKKYLYSVRDSSLQQKWQQVWQEINEETKQVREI 69

  Fly   127 QRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPPPTTQ 191
            ..||:...:                 |||.|| ||: |..|.||.               |...:
Zfish    70 MTTLESFQM-----------------ESTPSK-PSS-FAQDNDIM---------------PVHVE 100

  Fly   192 AVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRAGGRK 256
                      .|::|....   .|::|...::        ...:..:..|.|.||.:...|.|.|
Zfish   101 ----------HRSSPCVVR---KSSVPYKDSK--------GHGNRLSVGPRGQARPSPRVANGDK 144

  Fly   257 LSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDILQKDP 321
            .....:.|.:::.|....:...|         :|.:.|.::|..... :.:|:|.|||||:.::|
Zfish   145 GKPQKSKEKKENPSKPKEDKNKA---------EAVETEVKRFDRGGE-DKDLIDALERDIISQNP 199

  Fly   322 KVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTT 386
            .|.|.|||||.:||:||:|||||||.||::||||||||||||||||||||||:|||||||||.||
Zfish   200 NVTWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTT 264

  Fly   387 FFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELL 451
            ||||||:||||||||||||:|||||||||||||:|||||||||:|||||:..|||||||||:|||
Zfish   265 FFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELL 329

  Fly   452 VQMDGVGGGEEQ--AKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLREVKV 514
            ||||||||..|.  :|:|||||||||||||||||||||||||||||||.:||..||||||:|:.:
Zfish   330 VQMDGVGGTSENDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVDLLKINLKELDL 394

  Fly   515 DDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVSNKDFNEA 579
            .:.|::..:|.:::||||||||||||:||:|:|||:|.|||||:||.|..:|:.:|.:.:||..|
Zfish   395 ANDVNMDKIAEQMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLPKDEMHMPTTMEDFETA 459

  Fly   580 MSRCNKSVSRADLDKYEKWMREFGS 604
            :.:.:||||.|||:|||||:.||||
Zfish   460 LKKVSKSVSAADLEKYEKWIAEFGS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	10/79 (13%)
		P-loop_NTPase	325..>381	CDD:304359	46/55 (84%)
		AAA	358..496	CDD:214640	122/139 (88%)
		AAA	362..495	CDD:278434	117/134 (87%)
		Vps4_C	<570..603	CDD:286426	17/32 (53%)
katna1	NP_001018440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..173		15/91 (16%)
katna1	NP_001018440.1	SpoVK	<184..478	CDD:223540	212/293 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593589
Domainoid	1	1.000	241	1.000	Domainoid score	I2199
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1181
OMA	1	1.010	-	-		QHG59967
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm24974
orthoMCL	1	0.900	-	-		OOG6_102233
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5542
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.800