DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and FGGY

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001106882.1	Gene:	FGGY / 55277	HGNCID:	25610	Length:	575	Species:	Homo sapiens

Alignment Length:	279	Identity:	56/279 - (20%)
Similarity:	99/279 - (35%)	Gaps:	90/279 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 NNGGAAGDGENGD---------PQAAQEEERKFQP-----NNHIEAELVDILERDILQKDPKVRW 325
            |.||.:..|:..|         |:...:...:.|.     |:|:          |:::|...|.:
Human   327 NEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQSIYAYLNSHL----------DLIKKAQPVGF 381

  Fly   326 SDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNV 390
            ..: |||              :.|| |.|.|.|...:.:.|...||...:....|       .:.
Human   382 LTV-DLH--------------VWPD-FHGNRSPLADLTLKGMRTTGYLYIPALAA-------LHS 423

  Fly   391 SSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRV--------- 446
            .|:.|:.:..|  .|:.:.|.::|..|..:...|    :|.:|...|:...|...:
Human   424 PSSLLSPQVTG--LKLSQDLDDLAILYLATVQAI----ALGTRFIIEAMEAAGHSISTLFLCGGL 482

  Fly   447 -KSELLVQMDGVGGG-----EEQAKVVMVLAAT-------NFPWDIDEALRR----------RLE 488
             |:.|.|||.....|     .::.:.|:|.||.       :|. .:.||:.:          ||:
Human   483 SKNPLFVQMHADITGMPVVLSQEVESVLVGAAVLGACASGDFA-SVQEAMAKMSKVGKVVFPRLQ 546

  Fly   489 KRIYIPLPSDEGREALLKI 507
            .:.|.    |:..:..||:
Human   547 DKKYY----DKKYQVFLKL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	12/55 (22%)
		AAA	358..496	CDD:214640	33/169 (20%)
		AAA	362..495	CDD:278434	32/164 (20%)
		Vps4_C	<570..603	CDD:286426
FGGY	NP_001106882.1	FGGY_YpCarbK_like	10..568	CDD:212663	56/279 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900