Protein Alignment Kat60 and spast

DIOPT Version :10

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_012818464.1
• Gene: spast / 549207
• XenbaseID: XB-GENE-947839
• Length: 603
• Species: Xenopus tropicalis
• Alignment Length: 606
• Identity: 194/606 - (32%)
• Similarity: 298/606 - (49%)
• Gaps: 127/606 - (20%)

  Fly    28 TMTTTCSDR----QLLRGGKQKTTTCVGMTVMAKTTFEEICENA---------KLARDMALT--- 76
            |......||    :::|...|:....:.|.:......::..|.|         :|.:.:|:|
 Frog    95 TAAAPAQDRPQEPEVVRSYHQQAFQYISMALRIDEEEKDQKEQAIQWYKKGIEELEKGIAVTITG 159

  Fly    77 --GNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAIQRTLQDISLDLQS 139
              ..||.|    ..||..::..|....|.|             |..||:||          |:|.
 Frog   160 KGEQYDRA----RRLQAKMSTNLLMAKDRL-------------QLLAKLKA----------DIQG 197

  Fly   140 TKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPPPTTQAVGR-RAAPNNRR 203
               .|. :.::..::|.....:...||:... .|..|||       |..::.:..| :|||.
 Frog   198 ---QHS-QMEVCSDNTNLPCRNGLLKPEKGA-VPKKKDP-------PSISSNSYSRVKAAPK--- 247

  Fly   204 TTPATQNSRPSSTIPQSTARN-GPASTRNSRNSTSATAPSGGARTTNGRAGGRKLSTSNTNEARD 267
             :.:..|..|:.|...|:||. ||            .|||
 Frog   248 -SGSLGNRIPNCTGVSSSARQAGP------------NAPS------------------------- 274

  Fly   268 DDSTAAGNNGGAAG--DGENGDPQAAQEEERKFQPNN--HIEAELVDILERDILQKDPKVRWSDI 328
                    |.||||  :.....|.......||....|  ::::.|.:::..:|:...|.|:::||
 Frog   275 --------NRGAAGKNNTRTNKPTTPTTAVRKKDMKNLRNVDSNLANLILNEIVDSGPTVKFADI 331

  Fly   329 ADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSA 393
            |....||:.|:|.|:||.:.|:.|.|:|.|.:|:|:.||||.||||||||||.|...||||:|:|
 Frog   332 AGQDLAKQALQEIVILPSIRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAA 396

  Fly   394 TLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDS-LCSRRGSESEHEASRRVKSELLVQMDGV 457
            :|||||.||.||:||.||.:||...||.|||||:|| ||.||  |.||:||||:|:|.|::.|||
 Frog   397 SLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERR--EGEHDASRRLKTEFLIEFDGV 459

  Fly   458 -GGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINL--REVKVDDSVD 519
             .||:::   |:|:.|||.|.::|:|:.||..||:|:.||::|.|..||| ||  ::....:..:
 Frog   460 QSGGDDR---VLVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLLLLK-NLLSKQGNPLNEKE 520

  Fly   520 LTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVSNKDFNEAMSRCN 584
            ||.::...:||||:|||.:.::|::..:|.    |.|||::.:|..|: ..:...||..::.:..
 Frog   521 LTQLSRLTEGYSGSDITALAKDAALGPIRE----LKPEQVKNMAASEM-RNIKYSDFLSSLKKIK 580

  Fly   585 KSVSRADLDKYEKWMREFGSS 605
            .|||.:.|:.|.:|.:|||.:
 Frog   581 CSVSPSTLESYIRWNKEFGDT 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	Kp60-NTD	62..129	CDD:439297	18/80 (23%)
		PHA03291	<167..>253	CDD:223033	20/87 (23%)
		SpoVK	219..566	CDD:440232	140/355 (39%)
		RecA-like_KTNA1	327..493	CDD:410930	93/167 (56%)
		Vps4_C	<570..603	CDD:462762	9/32 (28%)
spast	XP_012818464.1	MIT_spastin	110..188	CDD:239142	17/94 (18%)
		RecA-like_spastin	330..493	CDD:410932	93/167 (56%)
		AAA_lid_3	520..554	CDD:465537	12/37 (32%)
		Vps4_C	<567..599	CDD:462762	9/31 (29%)