DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and psmc5

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001003740.1	Gene:	psmc5 / 445285	ZFINID:	ZDB-GENE-030131-6547	Length:	406	Species:	Danio rerio

Alignment Length:	293	Identity:	111/293 - (37%)
Similarity:	163/293 - (55%)	Gaps:	25/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 KFQPNNHIEAELVD-ILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFK--GIRRP 358
            |..||.      || ::...:::|.|...:..|..|....:.::|.:.||:..|:.|:  ||.:|
Zfish   125 KILPNK------VDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP 183

  Fly   359 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIF 423
             ||||:.||||||||:||:|||.....||..||.:.|..|:.||..:|||.||.|||.:|||.||
Zfish   184 -KGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIF 247

  Fly   424 IDEIDSLCSRR---GSESEHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRR 485
            :|||||:.|.|   ||..:.|. :|...|||.|:||.    |..|.:.|:.|||....:|.||.|
Zfish   248 MDEIDSIGSSRLEGGSGGDSEV-QRTMLELLNQLDGF----EATKNIKVIMATNRIDILDSALLR 307

  Fly   486 --RLEKRIYIPLPSDEGREALLKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMR 548
              |::::|..|.|::|.|..:|||:.|::.:...::|..:|..:.|.|||::..||.||.|.::|
Zfish   308 PGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALR 372

  Fly   549 RKIAGLTPEQIRQLATEEVDLPVSNKDFNEAMS 581
            .:...:|.|.......:     |..||..:.||
Zfish   373 ERRVHVTQEDFEMAVAK-----VMQKDSEKNMS 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	26/57 (46%)
		AAA	358..496	CDD:214640	69/142 (49%)
		AAA	362..495	CDD:278434	65/137 (47%)
		Vps4_C	<570..603	CDD:286426	5/12 (42%)
psmc5	NP_001003740.1	RPT1	4..404	CDD:224143	111/293 (38%)
		AAA_16	153..>206	CDD:289934	26/53 (49%)
		AAA	186..318	CDD:278434	65/136 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900