Protein Alignment Kat60 and spas

DIOPT Version :9

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 591
• Identity: 191/591 - (32%)
• Similarity: 296/591 - (50%)
• Gaps: 114/591 - (19%)

  Fly    57 KTTFEEICENAKLARDMALTGNYDSAC-IYYEGLQGLLARQLKATADPLRKGKWS---------- 110
            :..||.|.:..|:  |....|:.:.|. :|.:|        :|...|.:....||
  Fly   234 RRAFEYISKALKI--DEENEGHKELAIELYRKG--------IKELEDGIAVDCWSGRGDVWDRAQ 288

  Fly   111 ------MINQQISQEHAKIKAIQRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPD 169
                  ..|..::::.....|::.  ||:.:...|.|...|...|...:.|
  Fly   289 RLHDKMQTNLSMARDRLHFLALRE--QDLQMQRLSLKEKQKEEAQSKPQKT-------------- 337

  Fly   170 IWTPPPKDPDVWG----PPK---------PPPTTQ----AVGRRAAPNNRR-TTPATQNSRPSST 216
                  ::|.:.|    |.|         |..||.    |.||:....::| ...|..|.  |.|
  Fly   338 ------REPMLAGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVANK--SQT 394

  Fly   217 IPQST-ARNGPASTRNSRNSTSATAPSGGARTTNGRAGGRKLSTSNTNEARDDDSTAAGNNGGAA 280
            :|::. ::....:.:.....|:||.|:...:.::||         ||...|   |....||.|.:
  Fly   395 LPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGR---------NTPPQR---SRTPINNNGPS 447

  Fly   281 GDGENGDPQAAQEEERKFQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLP 345
            |.|.:....:.:..|:|          ||.::..:|::...||.|:|||....||:.|:|.|:||
  Fly   448 GSGASTPVVSVKGVEQK----------LVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILP 502

  Fly   346 MLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLL 410
            .:.|:.|.|:|.|.||:|:.||||.|||:||:||||||..||.|:|:|:|||||.|:.||:||.|
  Fly   503 SVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRAL 567

  Fly   411 FEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNF 475
            |.:||...||.|||||:|||.|.| |.||||||||:|:|.||:.||:.|..:..::| ||||||.
  Fly   568 FAVARHMQPSIIFIDEVDSLLSER-SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIV-VLAATNR 630

  Fly   476 PWDIDEALRRRLEKRIYIPLPSDEGREALL-KINLREVKVDDSVDLTYVANELKGYSGADITNVC 539
            |.::|||..||..||:|:.||.::.||.|| ::..::....|:..|..:|....||||:|:|.:.
  Fly   631 PQELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALA 695

  Fly   540 REASMMSMRRKIAGLTPEQIRQLATEEV---DL----PVSNKDFNEAMSRCNKSVSRADLDKYEK 597
            ::|::            |.||:|..|:|   |:    .::.:||:.::.|..:||:...|:.|||
  Fly   696 KDAAL------------EPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEK 748

  Fly   598 WMREFG 603
            |.:::|
  Fly   749 WSQDYG 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	20/98 (20%)
		P-loop_NTPase	325..>381	CDD:304359	30/55 (55%)
		AAA	358..496	CDD:214640	82/137 (60%)
		AAA	362..495	CDD:278434	79/132 (60%)
		Vps4_C	<570..603	CDD:286426	10/32 (31%)
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	14/83 (17%)
		P-loop_NTPase	482..>538	CDD:304359	30/55 (55%)
		AAA	515..652	CDD:214640	83/138 (60%)
		AAA	519..650	CDD:278434	79/132 (60%)
		Vps4_C	<722..754	CDD:286426	10/31 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940