Protein Alignment Kat60 and FIGNL2

DIOPT Version :10

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_016874787.1
• Gene: FIGNL2 / 401720
• HGNCID: 13287
• Length: 767
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 128/508 - (25%)
• Similarity: 202/508 - (39%)
• Gaps: 103/508 - (20%)

  Fly   160 PSAWFKPDPDIWTPPPKDPDV---------------WG----PPKPPPTTQAVGRRAAPNNRRTT 205
            |:|..:|.|    ||...|..               :|    ||.|||.........||     |
Human   298 PAALLQPPP----PPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAP-----T 353

  Fly   206 PATQNSRPSS-TIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRAGGRKLSTSNTNEARDDD 269
            |....:.|:: ..|  ||..|..|..:.:...:...|.|..|..........::        |..
Human   354 PLPAPAPPTAYGFP--TAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVA--------DGA 408

  Fly   270 STAAGNNGGAAGDGENGDPQAAQEE------------------------------ERKFQPN--- 301
            |..|.:||...|:|....|..|.||                              ||...|.
Human   409 SYPAADNGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGF 473

  Fly   302 --------NHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRP 358
                    ..::...::::...::...|.|:|:|:|.....|..|||.:|.|:|.|..:.|..||
Human   474 AVPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRP 538

  Fly   359 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIF 423
            .:.||:.||.|.||.:|.:.:||:.|.|...:..|||.:....|..::::..|..||...||.:.
Human   539 PRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLL 603

  Fly   424 IDEIDSLCSRRGSESEHEASRRVKSELLVQMD-GVGGGEEQAKVVMVLAATNFPWDIDEALRRRL 487
            |.|:::|...|  :....|...::..||..:| |.|.|   |..|:|:..|:.|..:|||.|||.
Human   604 ISELEALLPAR--DDGAAAGGALQVPLLACLDGGCGAG---ADGVLVVGTTSRPAALDEATRRRF 663

  Fly   488 EKRIYIPLPSDEGREALLKINLREVKVDDSV-DLTYVANELKGYSGADITNVCREASMMSMRRKI 551
            ..|.|:.||....|..:|:..|.:.....|. :|..:....:|:||.::..:|::|:..
Human   664 SLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAG------ 722

  Fly   552 AGLTPEQIRQLATEEVDLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFGS 604
            |||...|          .|:|.||...|:::.....|..:||.:.:|.:.:||
Human   723 AGLPGLQ----------RPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGS 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	Kp60-NTD	62..129	CDD:439297
		PHA03291	<167..>253	CDD:223033	23/105 (22%)
		SpoVK	219..566	CDD:440232	98/389 (25%)
		RecA-like_KTNA1	327..493	CDD:410930	57/166 (34%)
		Vps4_C	<570..603	CDD:462762	9/32 (28%)
FIGNL2	XP_016874787.1	RecA-like_fidgetin	507..669	CDD:410931	57/166 (34%)
		HflB	<643..>720	CDD:440233	23/76 (30%)