DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and psmc2

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_957260.1	Gene:	psmc2 / 393941	ZFINID:	ZDB-GENE-040426-1327	Length:	433	Species:	Danio rerio

Alignment Length:	280	Identity:	104/280 - (37%)
Similarity:	150/280 - (53%)	Gaps:	30/280 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 LQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYF--KGIRRPWKGVLMVGPPGTGKTMLAKAV 379
            :::.|.|.:||:....:....|.|.|..|:|.|:.|  .||..| ||||:.||||||||:.|:||
Zfish   166 VEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPP-KGVLLFGPPGTGKTLCARAV 229

  Fly   380 ATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRR---GSESEHE 441
            |......|..|..:.|..||.||..:|||.||||||......||.||||::...|   |:..::|
Zfish   230 ANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNE 294

  Fly   442 ASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSDEGREAL 504
            . :|...||:.|:||.    :....:.||.|||.|..:|.||.|  ||:::|...||..|||..:
Zfish   295 V-QRTMLELINQLDGF----DPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHI 354

  Fly   505 LKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDL 569
            .||:.|.:.|:..:....:|......:||:|.:||.||.|.::|.:         |::|||
Zfish   355 FKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRAR---------RKIATE---- 406

  Fly   570 PVSNKDFNEAMSRCNKSVSR 589
                |||.||:::..||.::
Zfish   407 ----KDFLEAVNKVIKSYAK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	27/57 (47%)
		AAA	358..496	CDD:214640	61/142 (43%)
		AAA	362..495	CDD:278434	58/137 (42%)
		Vps4_C	<570..603	CDD:286426	7/20 (35%)
psmc2	NP_957260.1	RPT1	23..430	CDD:224143	104/280 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900