DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and vps4b

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_009296349.1	Gene:	vps4b / 393880	ZFINID:	ZDB-GENE-040426-1235	Length:	515	Species:	Danio rerio

Alignment Length:	364	Identity:	153/364 - (42%)
Similarity:	213/364 - (58%)	Gaps:	56/364 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 NNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLE 339
            |:.|...|||. ||     |::|||  |.:...:|        .:.|.::|:|:|.|..||..|:
Zfish   170 NDKGNESDGEE-DP-----EKKKFQ--NQLSGAIV--------MEKPNIKWNDVAGLEGAKEALK 218

  Fly   340 EAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATEC-GTTFFNVSSATLTSKYRGES 403
            |||:||:..|..|.|.|.||:|:|:.|||||||:.||||||||. .:|||::||:.|.||:.|||
Zfish   219 EAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGES 283

  Fly   404 EKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVGGGEEQAKVVM 468
            ||:|:.||.:||.:.||.||||||||||..| ||:|.||:||:|:|.||||.|||...|.   ::
Zfish   284 EKLVKSLFTLAREHKPSIIFIDEIDSLCGSR-SENESEAARRIKTEFLVQMQGVGNDNEG---IL 344

  Fly   469 VLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLREV--KVDDSVDLTYVANELKGYS 531
            ||.|||.||.:|.|:|||.|||||||||.:..|..:.|:||...  .:.:| |...:..:..|||
Zfish   345 VLGATNIPWTLDSAIRRRFEKRIYIPLPEEHARSFMFKLNLGTTPNSLTES-DFMTLGKKTDGYS 408

  Fly   532 GADITNVCREASMMSMR--------RKIAG-------------LTP-----EQIRQLATEEV--- 567
            ||||:.:.|:|.|..:|        :::.|             |||     .|.:::...||
Zfish   409 GADISIIVRDALMQPVRKVQSATHFKQVRGPSRSDPNVIVDDLLTPCSPGDPQAKEMTWMEVPGE 473

  Fly   568 ---DLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFG 603
               :..||..|...::|....:|:..||:|.:|:..:||
Zfish   474 KLLEPIVSMSDMLRSLSNTKPTVNEQDLEKLKKFTEDFG 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	32/55 (58%)
		AAA	358..496	CDD:214640	86/138 (62%)
		AAA	362..495	CDD:278434	82/133 (62%)
		Vps4_C	<570..603	CDD:286426	9/32 (28%)
vps4b	XP_009296349.1	MIT	5..79	CDD:294211
		TPR	<8..>118	CDD:223533
		MIT	86..146	CDD:294211
		P-loop_NTPase	206..>260	CDD:304359	31/53 (58%)
		AAA	237..373	CDD:214640	87/139 (63%)
		AAA	241..371	CDD:278434	82/133 (62%)
		Vps4_C	452..512	CDD:286426	15/59 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910