Protein Alignment Kat60 and Spast

DIOPT Version :9

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_008762708.1
• Gene: Spast / 362700
• RGDID: 1308494
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 183/592 - (30%)
• Similarity: 286/592 - (48%)
• Gaps: 114/592 - (19%)

  Fly    41 GGKQKTTTCVGMTVMAKTTFEEICENAKLARDMALTGNYDSACIYY-----------------EG 88
            ||:.::     :.|..|..||.|....::..: ...|..:.|..:|                 :|
  Rat   108 GGEAES-----VRVFHKQAFEYISIALRIDEE-EKAGQKEQAVEWYKKGIEELEKGIAVIVTGQG 166

  Fly    89 LQGLLARQLKATADPLRKGKWSMINQQISQEHAK-IKAIQRTLQ----DISLDLQSTKFAHKLRH 148
            .|...||:|:|.         .|.|..::::..: ::.:|..||    ...:..:||....:..|
  Rat   167 EQYERARRLQAK---------MMTNLVMAKDRLQLLEKLQPVLQFSKSQTDVYNESTNLTCRNGH 222

  Fly   149 QLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPPPTTQAVGRRAAPNNRRTTPATQNSRP 213
            ..||....                          |.|..|.|.|                .||.|
  Rat   223 LQSESGAV--------------------------PKKKDPLTHA----------------SNSLP 245

  Fly   214 SSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRAGGRKLSTSNTNEARDDDSTAAGNNGG 278
            .|.....:...| .|..:...|.|..:...|||..:|.|......||..|......:
  Rat   246 RSKTVMKSGSTG-LSGHHRAPSCSGLSMVSGARPGSGPAATTHKGTSKPNRTNKPST-------- 301

  Fly   279 AAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVV 343
                     |..|..:::..:...::::.|.:::..:|:.....|::.|||....||:.|:|.|:
  Rat   302 ---------PTTAVRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVI 357

  Fly   344 LPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVR 408
            ||.|.|:.|.|:|.|.:|:|:.||||.||||||||||.|...||||:|:|:|||||.||.||:||
  Rat   358 LPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVR 422

  Fly   409 LLFEMARFYAPSTIFIDEIDS-LCSRRGSESEHEASRRVKSELLVQMDGV-GGGEEQAKVVMVLA 471
            .||.:||...||.|||||:|| ||.||  |.||:||||:|:|.|::.||| ..|:::   |:|:.
  Rat   423 ALFAVARELQPSIIFIDEVDSLLCERR--EGEHDASRRLKTEFLIEFDGVQSAGDDR---VLVMG 482

  Fly   472 ATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINL--REVKVDDSVDLTYVANELKGYSGAD 534
            |||.|.::|||:.||..||:|:.||::|.|..||| ||  ::.......:|..:|....||||:|
  Rat   483 ATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLK-NLLCKQGSPLTQKELAQLARMTDGYSGSD 546

  Fly   535 ITNVCREASMMSMRRKIAGLTPEQIRQLATEEV-DLPVSNKDFNEAMSRCNKSVSRADLDKYEKW 598
            :|.:.::|::..:|.    |.|||::.::..|: ::.:|  ||.|::.:..:|||...|:.|.:|
  Rat   547 LTALAKDAALGPIRE----LKPEQVKNMSASEMRNIRLS--DFTESLKKIKRSVSPQTLEAYIRW 605

  Fly   599 MREFGSS 605
            .::||.:
  Rat   606 NKDFGDT 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	13/79 (16%)
		P-loop_NTPase	325..>381	CDD:304359	31/55 (56%)
		AAA	358..496	CDD:214640	80/139 (58%)
		AAA	362..495	CDD:278434	78/134 (58%)
		Vps4_C	<570..603	CDD:286426	10/32 (31%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	16/88 (18%)
		P-loop_NTPase	339..>395	CDD:304359	31/55 (56%)
		AAA	372..508	CDD:214640	81/140 (58%)
		AAA	376..506	CDD:278434	78/134 (58%)
		Vps4_C	<578..610	CDD:286426	10/33 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910