DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kat60 and Vps4

DIOPT Version :9

Sequence 1:NP_001262276.1 Gene:Kat60 / 53566 FlyBaseID:FBgn0040208 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_001285396.1 Gene:Vps4 / 32777 FlyBaseID:FBgn0283469 Length:442 Species:Drosophila melanogaster


Alignment Length:386 Identity:157/386 - (40%)
Similarity:224/386 - (58%) Gaps:60/386 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 GRK--LSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERDI 316
            |:|  :.....:.|:||....:.:      |.|:||    ..|::|.|..          ||..|
  Fly    78 GKKKPIKEGGESSAKDDKDKKSDS------DDEDGD----DPEKKKLQSK----------LEDAI 122

  Fly   317 LQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVAT 381
            :.:.|||:|||:|.|..||..|:|||:||:..|..|.|.|.||||:|:.|||||||:.|||||||
  Fly   123 VIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVAT 187

  Fly   382 ECG-TTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRR 445
            |.. :|||:|||:.|.||:.|||||:|:.|||:||.:.||.||||||||:||.| |::|:::.||
  Fly   188 EANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSAR-SDNENDSVRR 251

  Fly   446 VKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINL- 509
            :|:|.||||.|||...:.   ::||.|||.||.:|.|:|||.|||||||||....|..:.||:| 
  Fly   252 IKTEFLVQMQGVGNDTDG---ILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLG 313

  Fly   510 REVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMR--------RKIAGLTPEQIRQLATE- 565
            ....|....||..:|.:.:|||||||:.|.|:|.|..:|        ::::|.:|....::..: 
  Fly   314 NTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDL 378

  Fly   566 ----------EVDL-------------PVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFG 603
                      .|::             ||:.:|..:::||...:|:..||.|..|:..:||
  Fly   379 LVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFG 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kat60NP_001262276.1 HCV_NS5a_C <163..243 CDD:289693
P-loop_NTPase 325..>381 CDD:304359 34/55 (62%)
AAA 358..496 CDD:214640 85/138 (62%)
AAA 362..495 CDD:278434 80/133 (60%)
Vps4_C <570..603 CDD:286426 10/32 (31%)
Vps4NP_001285396.1 MIT_VPS4 6..69 CDD:239141
RecA-like_VPS4 126..296 CDD:410929 102/173 (59%)
AAA_lid_3 323..361 CDD:407720 15/37 (41%)
Vps4_C 379..439 CDD:401324 11/59 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467086
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR23074
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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