DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and ATAD2

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_054828.2	Gene:	ATAD2 / 29028	HGNCID:	30123	Length:	1390	Species:	Homo sapiens

Alignment Length:	383	Identity:	129/383 - (33%)
Similarity:	193/383 - (50%)	Gaps:	28/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 NGPASTRNSRNSTSATAP-SGGARTTNGRAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGD 287
            :||||....|...|:..| |...:..|.|......|.|.::.:.:|:.........:.....|..
Human   323 SGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRC 387

  Fly   288 -PQAAQEEERK--FQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMP 349
             |...:::|.|  ::....|.|.|.|:   |.:|.|..||:..:..|.:....|:|.||.|:|.|
Human   388 LPLNFRKDELKGIYKDRMKIGASLADV---DPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYP 449

  Fly   350 DYFKGIR-RPWKGVLMVGPPGTGKTMLAKAVATECG-----TTFFNVSSATLTSKYRGESEKMVR 408
            :.|:..: :|.:|.|..||||||||::|:|:|.||.     ..||....|...||:.||||:.:|
Human   450 EVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLR 514

  Fly   409 LLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAAT 473
            |||:.|....||.||.||||.|...|.|..: :....:.|.||..|||:....|    ::|:.||
Human   515 LLFDQAYQMRPSIIFFDEIDGLAPVRSSRQD-QIHSSIVSTLLALMDGLDSRGE----IVVIGAT 574

  Fly   474 NFPWDIDEALRR--RLEKRIYIPLPSDEGREALLKINLRE--VKVDDSVDLTYVANELKGYSGAD 534
            |....||.||||  |.::.....||..|.|:.:|||:.|:  .|..|:. |..:|....||.|||
Human   575 NRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTF-LEELAENCVGYCGAD 638

  Fly   535 ITNVCREASMMSMRRKIAGL--TPEQIRQLATEEVDLPVSNKDFNEAMSRCNKSVSRA 590
            |.::|.||::.::||:...:  |.|:: ||....::  :|.|||..||.:...:..||
Human   639 IKSICAEAALCALRRRYPQIYTTSEKL-QLDLSSIN--ISAKDFEVAMQKMIPASQRA 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	7/19 (37%)
		P-loop_NTPase	325..>381	CDD:304359	22/56 (39%)
		AAA	358..496	CDD:214640	59/144 (41%)
		AAA	362..495	CDD:278434	57/139 (41%)
		Vps4_C	<570..603	CDD:286426	8/21 (38%)
ATAD2	NP_054828.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..380		13/56 (23%)
		AAA	459..600	CDD:214640	60/145 (41%)
		AAA	464..598	CDD:278434	57/138 (41%)
		COG5076	<915..1153	CDD:227408
		Bromo_AAA	987..1097	CDD:99957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1242
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900