DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and Fignl1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001011913.1	Gene:	Fignl1 / 289777	RGDID:	1307112	Length:	677	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	211/668 - (31%)
Similarity:	301/668 - (45%)	Gaps:	165/668 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VMAKTTFEEICE--NAKLARDMALTG--NYDSACIYYEGLQGLLARQLKATADPLRKGKWS---M 111
            |.|...|:...|  :|.:..|..:||  ||..:.....|.|       :|.:|     ||.   .
  Rat    54 VFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSQ-------QADSD-----KWQSGLS 106

  Fly   112 INQQISQEHAKIKAIQRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKP---------D 167
            ||...     |:..:|..:|      ...||...|...........|:|:.:..|         :
  Rat   107 INNVF-----KMSTVQEMMQ------AGQKFKESLLEPADASVVMCKEPTIFEVPQLGVCGGSEE 160

  Fly   168 PDIWTPPPKDPDVWGPPKPPPTTQAV---GRRAAP---------NNRRT---------------- 204
            .|:.:     ..|.|..|    |||:   ..|.:|         .|.:|
  Rat   161 ADLLS-----SSVHGTEK----TQAIPGNSLRCSPFQSTLFPMATNTKTCLTSSAPSGESTTATF 216

  Fly   205 --TPATQNSR--PSSTIPQSTARN--------GPASTRNSR---------------NSTSATAPS 242
              ||...|::  |.|....||..|        .|:...|.|               |.|...|||
  Rat   217 HRTPLFGNTKKEPQSFPKTSTGLNMFLSNPSCVPSGCENPRERKAFNDSDTINMLSNPTLNKAPS 281

  Fly   243 ----GGARTTNGR-----------AGGRKLS-----TSNTNEARDDDSTAAGNNGGAAG------ 281
                .|.|..|..           |..:|.|     ||.:.......|..||.:.|..|
  Rat   282 KTEDSGQREDNSLPTFKTAKEQLWADQKKRSHQSQHTSKSFNGAIKKSLGAGRSRGIFGKFVPPV 346

  Fly   282 ----DG--ENGDPQAAQEEERKFQPNN-------HIEAELVDILERDILQKDPKVRWSDIADLHD 333
                ||  :||:.:.........:|.:       ::|..:|:::..:|:...|.|.|.|||.:..
  Rat   347 SNKQDGSEQNGNVKPKSSRAGSAEPAHLTDDRLKNVEPRMVELIMNEIMDHGPPVHWEDIAGVEF 411

  Fly   334 AKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSK 398
            ||..::|.||.||:.||.|.|:|.|.||:|:.||||||||::.|.:|::.|.|||::|:::||||
  Rat   412 AKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSK 476

  Fly   399 YRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVGGGEEQ 463
            :.||.|||||.||.:||...|:.|||||||||.|:|| :.|||:|||:|:|.|||:||.....|.
  Rat   477 WVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG-DGEHESSRRIKTEFLVQLDGATTSSED 540

  Fly   464 AKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLREVK----VDDSVDLTYVA 524
            .  ::|:.|||.|.:||||.||||.||:|||||....|:.:: :||...:    .|:..:|  |.
  Rat   541 R--ILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIV-VNLMSKEQCCLTDEETEL--VV 600

  Fly   525 NELKGYSGADITNVCREASMMSMR----RKIAGLTPEQIRQLATEEVDLPVSNKDFNEAMSRCNK 585
            .:..|:||||:|.:|||||:..:|    ..||.::|:|:|         |::..||..|......
  Rat   601 QQSDGFSGADMTQLCREASLGPIRSLHTADIATISPDQVR---------PIAYIDFENAFRTVRP 656

  Fly   586 SVSRADLDKYEKWMREFG 603
            |||..||:.||.|.:.||
  Rat   657 SVSPKDLELYENWNKTFG 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	28/147 (19%)
		P-loop_NTPase	325..>381	CDD:304359	29/55 (53%)
		AAA	358..496	CDD:214640	79/137 (58%)
		AAA	362..495	CDD:278434	75/132 (57%)
		Vps4_C	<570..603	CDD:286426	12/32 (38%)
Fignl1	NP_001011913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..232		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..324		16/74 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..378		7/40 (18%)
		RecA-like_Figl-1	383..568	CDD:410933	97/187 (52%)
		AAA_lid_3	593..>624	CDD:407720	14/32 (44%)
		Vps4_C	<634..674	CDD:401324	15/48 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840