DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and Katnal1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001006957.1	Gene:	Katnal1 / 288449	RGDID:	1359252	Length:	488	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	292/553 - (52%)
Similarity:	367/553 - (66%)	Gaps:	78/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAI 126
            |||||||..|:.||.|||||:.:||:|:...:.|..::..||..|.||..:.|::.:|:.::|:|
  Rat     5 EICENAKKGREYALLGNYDSSMVYYQGVIQQIQRHCQSLRDPATKAKWQQVRQELLEEYEQVKSI 69

  Fly   127 QRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTP------PPKDPDVWGPPK 185
            ..||:...:|                            || ||.  |      |.:||.||.||.
  Rat    70 VSTLESFKMD----------------------------KP-PDF--PVSCRDEPFRDPAVWPPPV 103

  Fly   186 PPPTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNG 250
            |      ...||.|..|         ||:..:            |..|....|     |||...|
  Rat   104 P------AEHRAPPQIR---------RPNREV------------RPLRKDMGA-----GARGLVG 136

  Fly   251 RAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERD 315
            ||  .::|.|:...:||.|..|.|.:..|..:.::|   |:..|..||....: :.:||:.||||
  Rat   137 RA--HQISKSDKAASRDKDYRARGRDDKARKNMQDG---ASDGEIPKFDGAGY-DKDLVEALERD 195

  Fly   316 ILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVA 380
            |:.::|.:.|.|||||.:||:||.|||||||.|||:|||||||||||||||||||||||||||||
  Rat   196 IVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVA 260

  Fly   381 TECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRR 445
            ||||||||||||:||||||||||||:|||||||||||||:|||||||||:|||||:..|||||||
  Rat   261 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRR 325

  Fly   446 VKSELLVQMDGVGG---GEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKI 507
            ||||||:|||||||   .::.:|:||||||||||||||||||||||||||||||:.:||..||||
  Rat   326 VKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKI 390

  Fly   508 NLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVS 572
            :||||::|..:.|..:|.:.:|||||||||:||:||:|:|||:|.||:||:||.|:.||:.:||:
  Rat   391 SLREVELDPDIHLEDIAEKTEGYSGADITNICRDASLMAMRRRINGLSPEEIRALSKEELQMPVT 455

  Fly   573 NKDFNEAMSRCNKSVSRADLDKYEKWMREFGSS 605
            ..|...|:.:..||||.|||:||||||.||||:
  Rat   456 RGDLELALKKIAKSVSAADLEKYEKWMVEFGSA 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	22/85 (26%)
		P-loop_NTPase	325..>381	CDD:304359	48/55 (87%)
		AAA	358..496	CDD:214640	123/140 (88%)
		AAA	362..495	CDD:278434	118/135 (87%)
		Vps4_C	<570..603	CDD:286426	18/32 (56%)
Katnal1	NP_001006957.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..179		18/60 (30%)
		RecA-like_KTNA1	207..376	CDD:410930	145/168 (86%)
		AAA_lid_3	400..444	CDD:407720	25/43 (58%)
		Vps4_C	<448..486	CDD:401324	20/37 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351769
Domainoid	1	1.000	241	1.000	Domainoid score	I2172
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12942
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1215
OMA	1	1.010	-	-		QHG59967
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm44755
orthoMCL	1	0.900	-	-		OOG6_102233
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770