Protein Alignment Kat60 and knk1

DIOPT Version :10

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_595275.1
• Gene: knk1 / 2541249
• PomBaseID: SPBC947.01
• Length: 660
• Species: Schizosaccharomyces pombe
• Alignment Length: 603
• Identity: 196/603 - (32%)
• Similarity: 289/603 - (47%)
• Gaps: 90/603 - (14%)

  Fly    29 MTTTCSDRQLLRGGKQKTTTCVGMTVMAK-----TTFEEICENAKLARDMALTGNYDSACIYYEG 88
            |||....|| .||.:.:........:.:|     |:...|           ::.:|..|..|
pombe   119 MTTRMMYRQ-TRGAQSEVNLSTPKQIYSKHSPPSTSTSSI-----------VSSSYGDAPSY--- 168

  Fly    89 LQGLLARQLKATADPLR-KGKWSMINQQISQEHAKIKAIQRTLQDISLD------LQSTKFAHKL 146
                ||......:.||: :..::..|...|...|..|:...:...:|.|      :.||.|...:
pombe   169 ----LAPSKPNRSPPLKPEDPFASFNSSASAIAAASKSAAASASALSSDTGRSATMNSTTFPTAM 229

  Fly   147 RHQLSEESTTSKDPSAWFKPDPDIWTPPPKD-----PDVWGPPKPPPTTQAVGRRAAPNNRRTTP 206
            :.|.:.:.|.|...|:     |.|.....::     |..:..|.||....||            |
pombe   230 KSQSTTKPTLSNSVSS-----PSIQVSNNQNANNSTPLSFHAPIPPLHVPAV------------P 277

  Fly   207 ATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRAGGRKLSTSNTNEARDDDST 271
            .|..|..||   ...:|..|:..:...||:..|..|....::...||    |.:.:..|..|..|
pombe   278 LTSASHSSS---DGKSRKHPSPYKPYLNSSHDTLGSSTRPSSADTAG----SPATSPPATADSKT 335

  Fly   272 AAGNNGGAAGDGENGDPQAAQEEE--RKFQPNNHIEAELVDILERDILQKDPKVRWSDIADLHDA 334
            .......|:         ..|:.|  ::..|::..|..:::    :|:.....|.|||||.|.||
pombe   336 IVSKTISAS---------TTQQTEPLQQTTPSSDFEYAIMN----EIISNHEPVYWSDIAGLDDA 387

  Fly   335 KRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKY 399
            |..|:|||:.|.|.|:.|:|:|.|.:|:|:.|||||||||||:|||||...|||::|:::|||||
pombe   388 KNSLKEAVIYPFLRPELFQGLREPVQGMLLFGPPGTGKTMLARAVATEAKATFFSISASSLTSKY 452

  Fly   400 RGESEKMVRLLFEMARFYAPSTIFIDEIDSLCS-RRGSESEHEASRRVKSELLVQMDGVGGGEEQ 463
            .|:|||:||.|||:|:....|.||:|||||:.| |..|.:|||:|||:|:|.|:|...:......
pombe   453 LGDSEKLVRALFEVAKRQTCSVIFVDEIDSILSARNDSGNEHESSRRLKTEFLIQWSSLTNAAPD 517

  Fly   464 AKV-----VMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGR-EALLKINLREVKVDDSVDLTY 522
            .:.     |:||||||.||.||||.|||..||.|||||..|.| :.|..:...:|......||..
pombe   518 KQTGHSPRVLVLAATNLPWCIDEAARRRFVKRTYIPLPEKETRYKHLSHLLHNQVHCLTEEDLEE 582

  Fly   523 VANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATE-EVDLPVSNKDFNEAMSRCNKS 586
            :.|..:||||:|||.:.::|:|..:|.....|       |.|. |:..|:|...|..::.....|
pombe   583 LVNLTEGYSGSDITALAKDAAMGPLRNLGDAL-------LTTSAEMIPPISLNHFKASLRTIRPS 640

  Fly   587 VSRADLDKYEKWMREFGS 604
            ||:..:.:||:|.::|||
pombe   641 VSQEGIHRYEEWNKQFGS 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	Kp60-NTD	62..129	CDD:439297	12/67 (18%)
		PHA03291	<167..>253	CDD:223033	19/90 (21%)
		SpoVK	219..566	CDD:440232	140/356 (39%)
		RecA-like_KTNA1	327..493	CDD:410930	94/171 (55%)
		Vps4_C	<570..603	CDD:462762	9/32 (28%)
knk1	NP_595275.1	Herpes_BLLF1	<221..>359	CDD:282904	36/170 (21%)
		RecA-like_VPS4-like	381..552	CDD:410917	93/170 (55%)
		AAA_lid_3	577..614	CDD:465537	13/36 (36%)
		Vps4_C	<623..657	CDD:462762	9/33 (27%)