DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and Vps4a

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_006255622.2	Gene:	Vps4a / 246772	RGDID:	628810	Length:	447	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	146/354 - (41%)
Similarity:	202/354 - (57%)	Gaps:	66/354 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 NGRAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILE 313
            |....|:|....|.:|.:..||.:.|:|                .|::|.|          :.|.
  Rat    76 NKEKHGKKPVKENQSEGKGSDSDSEGDN----------------PEKKKLQ----------EQLM 114

  Fly   314 RDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKA 378
            ..::.:.|.:||:|:|.|..||..|:|||:||:..|..|.|.|.||:|:|:.|||||||:.||||
  Rat   115 GAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKA 179

  Fly   379 VATEC-GTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEA 442
            ||||. .:|||:|||:.|.||:.|||||:|:.|||:||.:.||.|||||:||||..| :|:|.||
  Rat   180 VATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR-NENESEA 243

  Fly   443 SRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKI 507
            :||:|:|.||||.|||...:.   .:||.|||.||.:|.|:|||.|||||||||.:..|..:.::
  Rat   244 ARRIKTEFLVQMQGVGNNNDG---TLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRL 305

  Fly   508 -------NLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLAT- 564
                   ||.:..:.:      :|.:.:|||||||:.:.|: |:|...||:         |.||
  Rat   306 HLGSTPHNLTDANIHE------LARKTEGYSGADISIIVRD-SLMQPVRKV---------QSATH 354

  Fly   565 -EEVDLPVSNKDFNEAMSRCNKSVSRADL 592
             ::|..|          ||.|.||...||
  Rat   355 FKKVCGP----------SRTNPSVMIDDL 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	32/55 (58%)
		AAA	358..496	CDD:214640	85/138 (62%)
		AAA	362..495	CDD:278434	81/133 (61%)
		Vps4_C	<570..603	CDD:286426	8/23 (35%)
Vps4a	XP_006255622.2	PTZ00454	4..348	CDD:240423	132/308 (43%)
		MIT_VPS4	4..79	CDD:239141	1/2 (50%)
		P-loop_NTPase	128..>182	CDD:304359	31/53 (58%)
		AAA	163..293	CDD:278434	81/133 (61%)
		Vps4_C	374..>404	CDD:286426	146/354 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840