DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and Katnal1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_705800.1	Gene:	Katnal1 / 231912	MGIID:	2387638	Length:	488	Species:	Mus musculus

Alignment Length:	553	Identity:	293/553 - (52%)
Similarity:	368/553 - (66%)	Gaps:	78/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAI 126
            |||||||..|:.||.|||||:.:||:|:...:.|..::..||..|.||..:.|::.:|:.::|:|
Mouse     5 EICENAKKGREYALLGNYDSSMVYYQGVIQQIQRHCQSLRDPATKAKWQQVRQELLEEYEQVKSI 69

  Fly   127 QRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTP------PPKDPDVWGPPK 185
            ..||:...:|                            || ||.  |      |.:||.||.||.
Mouse    70 VSTLESFKMD----------------------------KP-PDF--PVSCRDEPFRDPAVWPPPV 103

  Fly   186 PPPTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNG 250
            |      ...||.|..|         ||:..:            |..|....|     |||...|
Mouse   104 P------AEHRAPPQIR---------RPNREV------------RPLRKDVGA-----GARGLVG 136

  Fly   251 RAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERD 315
            ||  .::|.|:...:||.|..|.|.:..|..:.::|   |:..|..||....: :.:||:.||||
Mouse   137 RA--HQISKSDKPASRDKDYRARGRDDKARKNVQDG---ASDSEIPKFDGAGY-DKDLVEALERD 195

  Fly   316 ILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVA 380
            |:.::|.:.|.|||||.:||:||.|||||||.|||:|||||||||||||||||||||||||||||
Mouse   196 IVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVA 260

  Fly   381 TECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRR 445
            ||||||||||||:||||||||||||:|||||||||||||:|||||||||:|||||:..|||||||
Mouse   261 TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRR 325

  Fly   446 VKSELLVQMDGVGG---GEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKI 507
            ||||||:|||||||   .::.:|:||||||||||||||||||||||||||||||:.:||..||||
Mouse   326 VKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKI 390

  Fly   508 NLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVS 572
            :||||::|..|.|..:|::.:|||||||||:||:||:|:|||:|.||:||:||.|:.||:.:||:
Mouse   391 SLREVELDPDVHLEDIADKTEGYSGADITNICRDASLMAMRRRINGLSPEEIRALSKEELQMPVT 455

  Fly   573 NKDFNEAMSRCNKSVSRADLDKYEKWMREFGSS 605
            ..|...|:.:..||||.|||:||||||.||||:
Mouse   456 RGDLELALKKIAKSVSAADLEKYEKWMVEFGSA 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	22/85 (26%)
		P-loop_NTPase	325..>381	CDD:304359	48/55 (87%)
		AAA	358..496	CDD:214640	123/140 (88%)
		AAA	362..495	CDD:278434	118/135 (87%)
		Vps4_C	<570..603	CDD:286426	18/32 (56%)
Katnal1	NP_705800.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..179		33/120 (28%)
Katnal1	NP_705800.1	SpoVK	<186..481	CDD:223540	214/294 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848191
Domainoid	1	1.000	241	1.000	Domainoid score	I2237
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12942
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1240
Isobase	1	0.950	-	0	Normalized mean entropy	S1180
OMA	1	1.010	-	-		QHG59967
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm42690
orthoMCL	1	0.900	-	-		OOG6_102233
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5542
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740