DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and Psmc1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_032973.1	Gene:	Psmc1 / 19179	MGIID:	106054	Length:	440	Species:	Mus musculus

Alignment Length:	355	Identity:	113/355 - (31%)
Similarity:	183/355 - (51%)	Gaps:	65/355 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 GRKLSTSNTNEARDDD----STAAGNNGGAAGDGENGDPQAAQEEERKFQPN-----NHIEAELV 309
            |..:|.....|..||:    ||:.|:        |:.....:..::...:|.     ||....::
Mouse   104 GTPMSVGTLEEIIDDNHAIVSTSVGS--------EHYVSILSFVDKDLLEPGCSVLLNHKVHAVI 160

  Fly   310 DILERDI--------LQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFK--GIRRPWKGVLM 364
            .:|..|.        ::|.|:..::||..|.:..:.::|:|.||:..|:|::  ||:.| |||::
Mouse   161 GVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPP-KGVIL 224

  Fly   365 VGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDS 429
            .||||||||:||||||.:...||..|..:.|..||.|:..|:||.||.:|..:|||.:||||||:
Mouse   225 YGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDA 289

  Fly   430 LCSRR-----GSESEHEASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRR--RL 487
            :.::|     |.|.|   .:|...|||.|:||.....:    |.|:.|||....:|.||.|  |:
Mouse   290 IGTKRYDSNSGGERE---IQRTMLELLNQLDGFDSRGD----VKVIMATNRIETLDPALIRPGRI 347

  Fly   488 EKRIYIPLPSDEGREALLKINLREVKVDDSV---DLTYVANELKGYSGADITNVCREASMMSMRR 549
            :::|..|||.::.::.:.:|:...:.:.|.|   ||....::|   |||||..:|.||.:|::|
Mouse   348 DRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDL---SGADIKAICTEAGLMALR- 408

  Fly   550 KIAGLTPEQIRQLATEEVDLPVSNKDFNEA 579
                            |..:.|:|:||.::
Mouse   409 ----------------ERRMKVTNEDFKKS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	28/57 (49%)
		AAA	358..496	CDD:214640	63/144 (44%)
		AAA	362..495	CDD:278434	59/139 (42%)
		Vps4_C	<570..603	CDD:286426	4/10 (40%)
Psmc1	NP_032973.1	PTZ00361	1..440	CDD:185575	113/355 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..104		113/355 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900