DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and mei-1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001370150.1	Gene:	mei-1 / 172612	WormBaseID:	WBGene00003183	Length:	475	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	188/557 - (33%)
Similarity:	271/557 - (48%)	Gaps:	113/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAIQRT 129
            |.|::|:.|:..|.::.|        |.|.|||..   .::..|.|..|:   .||.......|.
Worm    14 ERAQVAKTMSDAGRWNEA--------GDLLRQLMT---DVKSCKISASNR---DEHDARNTFLRA 64

  Fly   130 LQ-DISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPP------ 187
            |: ::.|..|:.:....|...::.:|.:.:               ||.|||||..|.||
Worm    65 LEANLKLVQQNVRDEDDLHEAMTRQSGSPE---------------PPADPDVWSKPSPPLPSSSK 114

  Fly   188 --PTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNG 250
              .|.:.|| .|.|..|..:.:|           |:....||..:.: |.|....|.
Worm   115 FGATKKGVG-AAGPRPREISKST-----------SSMSTNPADVKPA-NPTQGILPQ-------- 158

  Fly   251 RAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERD 315
                                    |:.|.:.|....|....|........|......|
Worm   159 ------------------------NSAGDSFDASAYDAYIVQAVRGTMATNTENTMSL------- 192

  Fly   316 ILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVA 380
                      .||..:||.|::|.|||.||:|:|::|:|:|.|||.:::.||||||||::|:|:|
Worm   193 ----------DDIIGMHDVKQVLHEAVTLPLLVPEFFQGLRSPWKAMVLAGPPGTGKTLIARAIA 247

  Fly   381 TECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRR 445
            :|..:|||.|||..|:||:||:|||:||||||:|||||||.|||||||:|..:||:..|||||||
Worm   248 SESSSTFFTVSSTDLSSKWRGDSEKIVRLLFELARFYAPSIIFIDEIDTLGGQRGNSGEHEASRR 312

  Fly   446 VKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLR 510
            ||||.|||||| ...:..::.|.||||||.||::|||||||.||||:||||..:.|:.|::.::.
Worm   313 VKSEFLVQMDG-SQNKFDSRRVFVLAATNIPWELDEALRRRFEKRIFIPLPDIDARKKLIEKSME 376

  Fly   511 EVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKI--------AGLTPEQIRQLATEEV 567
            .....|.::...:|...:|:||||:.::||.|::..:||..        .|.....:..|..|
Worm   377 GTPKSDEINYDDLAARTEGFSGADVVSLCRTAAINVLRRYFRYDTKSLRGGELTAAMESLKAE-- 439

  Fly   568 DLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFGS 604
              .|.|.||..|:...:.|.....:.|.::|...||:
Worm   440 --LVRNIDFEAALQAVSPSAGPDTMLKCKEWCDSFGA 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	23/87 (26%)
		P-loop_NTPase	325..>381	CDD:304359	29/55 (53%)
		AAA	358..496	CDD:214640	91/137 (66%)
		AAA	362..495	CDD:278434	87/132 (66%)
		Vps4_C	<570..603	CDD:286426	8/32 (25%)
mei-1	NP_001370150.1	RecA-like_VPS4-like	195..359	CDD:410917	104/164 (63%)
mei-1	NP_001370150.1	AAA_lid_3	383..423	CDD:407720	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157715
Domainoid	1	1.000	181	1.000	Domainoid score	I2067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I1817
Isobase	1	0.950	-	0	Normalized mean entropy	S1180
OMA	1	1.010	-	-		QHG59967
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm14421
orthoMCL	1	0.900	-	-		OOG6_102233
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.750