Protein Alignment Kat60 and mei-1

DIOPT Version :10

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001370150.1
• Gene: mei-1 / 172612
• WormBaseID: WBGene00003183
• Length: 475
• Species: Caenorhabditis elegans
• Alignment Length: 557
• Identity: 188/557 - (33%)
• Similarity: 271/557 - (48%)
• Gaps: 113/557 - (20%)

  Fly    65 ENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAIQRT 129
            |.|::|:.|:..|.::.|        |.|.|||..   .::..|.|..|:   .||.......|.
 Worm    14 ERAQVAKTMSDAGRWNEA--------GDLLRQLMT---DVKSCKISASNR---DEHDARNTFLRA 64

  Fly   130 LQ-DISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPP------ 187
            |: ::.|..|:.:....|...::.:|.:.:               ||.|||||..|.||
 Worm    65 LEANLKLVQQNVRDEDDLHEAMTRQSGSPE---------------PPADPDVWSKPSPPLPSSSK 114

  Fly   188 --PTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGARTTNG 250
              .|.:.|| .|.|..|..:.:|           |:....||..:.: |.|....|.
 Worm   115 FGATKKGVG-AAGPRPREISKST-----------SSMSTNPADVKPA-NPTQGILPQ-------- 158

  Fly   251 RAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILERD 315
                                    |:.|.:.|....|....|........|......|
 Worm   159 ------------------------NSAGDSFDASAYDAYIVQAVRGTMATNTENTMSL------- 192

  Fly   316 ILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVA 380
                      .||..:||.|::|.|||.||:|:|::|:|:|.|||.:::.||||||||::|:|:|
 Worm   193 ----------DDIIGMHDVKQVLHEAVTLPLLVPEFFQGLRSPWKAMVLAGPPGTGKTLIARAIA 247

  Fly   381 TECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRR 445
            :|..:|||.|||..|:||:||:|||:||||||:|||||||.|||||||:|..:||:..|||||||
 Worm   248 SESSSTFFTVSSTDLSSKWRGDSEKIVRLLFELARFYAPSIIFIDEIDTLGGQRGNSGEHEASRR 312

  Fly   446 VKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLR 510
            ||||.|||||| ...:..::.|.||||||.||::|||||||.||||:||||..:.|:.|::.::.
 Worm   313 VKSEFLVQMDG-SQNKFDSRRVFVLAATNIPWELDEALRRRFEKRIFIPLPDIDARKKLIEKSME 376

  Fly   511 EVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKI--------AGLTPEQIRQLATEEV 567
            .....|.::...:|...:|:||||:.::||.|::..:||..        .|.....:..|..|
 Worm   377 GTPKSDEINYDDLAARTEGFSGADVVSLCRTAAINVLRRYFRYDTKSLRGGELTAAMESLKAE-- 439

  Fly   568 DLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFGS 604
              .|.|.||..|:...:.|.....:.|.::|...||:
 Worm   440 --LVRNIDFEAALQAVSPSAGPDTMLKCKEWCDSFGA 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	Kp60-NTD	62..129	CDD:439297	16/63 (25%)
		PHA03291	<167..>253	CDD:223033	23/93 (25%)
		SpoVK	219..566	CDD:440232	138/354 (39%)
		RecA-like_KTNA1	327..493	CDD:410930	105/165 (64%)
		Vps4_C	<570..603	CDD:462762	8/32 (25%)
mei-1	NP_001370150.1	SpoVK	53..414	CDD:440232	159/438 (36%)
		RecA-like_VPS4-like	195..359	CDD:410917	104/164 (63%)