DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and Vps4a

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_569053.1	Gene:	Vps4a / 116733	MGIID:	1890520	Length:	437	Species:	Mus musculus

Alignment Length:	395	Identity:	149/395 - (37%)
Similarity:	215/395 - (54%)	Gaps:	76/395 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 NGRAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVDILE 313
            |....|:|....|.:|.:..||.:.|:|                .|::|.|          :.|.
Mouse    76 NKEKHGKKPVKENQSEGKGSDSDSEGDN----------------PEKKKLQ----------EQLM 114

  Fly   314 RDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKA 378
            ..::.:.|.:||:|:|.|..||..|:|||:||:..|..|.|.|.||:|:|:.|||||||:.||||
Mouse   115 GAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKA 179

  Fly   379 VATEC-GTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEA 442
            ||||. .:|||:|||:.|.||:.|||||:|:.|||:||.:.||.|||||:||||..| :|:|.||
Mouse   180 VATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSR-NENESEA 243

  Fly   443 SRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKI 507
            :||:|:|.||||.|||...:.   .:||.|||.||.:|.|:|||.|||||||||.:..|..:.::
Mouse   244 ARRIKTEFLVQMQGVGNNNDG---TLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRL 305

  Fly   508 -------NLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMR--------RKIAG---- 553
                   ||.:..:.:      :|.:.:|||||||:.:.|::.|..:|        :|:.|
Mouse   306 HLGSTPHNLTDANIHE------LARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRT 364

  Fly   554 ---------LTPEQIRQLATEE---VDLP--------VSNKDFNEAMSRCNKSVSRADLDKYEKW 598
                     |||.........|   :|:|        |...|...:::....:|:..||.|.:|:
Mouse   365 NPSVMIDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKF 429

  Fly   599 MREFG 603
            ..:||
Mouse   430 SEDFG 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	32/55 (58%)
		AAA	358..496	CDD:214640	85/138 (62%)
		AAA	362..495	CDD:278434	81/133 (61%)
		Vps4_C	<570..603	CDD:286426	8/40 (20%)
Vps4a	NP_569053.1	PTZ00454	4..348	CDD:240423	131/307 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..106		9/45 (20%)
		RecA-like_VPS4	121..291	CDD:410929	100/173 (58%)
		Vps4_C	374..434	CDD:401324	13/59 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840