Protein Alignment Kat60 and KATNA1

DIOPT Version :9

• Sequence 1: NP_001262276.1
• Gene: Kat60 / 53566
• FlyBaseID: FBgn0040208
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_008975.1
• Gene: KATNA1 / 11104
• HGNCID: 6216
• Length: 491
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 283/548 - (51%)
• Similarity: 367/548 - (66%)
• Gaps: 69/548 - (12%)

  Fly    63 ICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEHAKIKAIQ 127
            |.||.||||:.||.||||||.:||:|:...:.:.|.:..|...:.||..:.|:|:.|...:|.|.
Human     6 ISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIM 70

  Fly   128 RTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPKPPPTTQA 192
            :||:...||....|.|   :|.|                       |..:.:||..|.|.....:
Human    71 KTLESFKLDSTPLKAA---QHDL-----------------------PASEGEVWSMPVPVERRPS 109

  Fly   193 VGRRAAPNNRRTTPATQNSRPSST--IPQSTARNGPASTRNSRNSTSATAPSGGARTTNGRAGGR 255
            .|.|...:::.:.|.:..:|||:|  :.:|:|:|    ..|.|                |:| .|
Human   110 PGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQN----VHNDR----------------GKA-VR 153

  Fly   256 KLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQE-EERKFQPNNHIEAELVDILERDILQK 319
            .......|:.|::               :|..|.|..| |..||....: :.:||:.|||||:.:
Human   154 CREKKEQNKGREE---------------KNKSPAAVTEPETNKFDSTGY-DKDLVEALERDIISQ 202

  Fly   320 DPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECG 384
            :|.|||.|||||.:||:||:|||||||.||::||||||||||||||||||||||:|||||||||.
Human   203 NPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECK 267

  Fly   385 TTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSE 449
            ||||||||:||||||||||||:|||||||||||:|:|||||||||:|||||:..|||||||||:|
Human   268 TTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAE 332

  Fly   450 LLVQMDGVGG---GEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLKINLRE 511
            ||||||||||   .::.:|:|||||||||||||||||||||||||||||||.:|||.||:|:|||
Human   333 LLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRE 397

  Fly   512 VKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLPVSNKDF 576
            :::.|.|||..:|..::||||||||||||:||:|:|||:|.|||||:||.|:.||:.:|.:.:||
Human   398 LELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDF 462

  Fly   577 NEAMSRCNKSVSRADLDKYEKWMREFGS 604
            ..|:.:.:||||.||:::||||:.||||
Human   463 EMALKKVSKSVSAADIERYEKWIFEFGS 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	17/81 (21%)
		P-loop_NTPase	325..>381	CDD:304359	46/55 (84%)
		AAA	358..496	CDD:214640	120/140 (86%)
		AAA	362..495	CDD:278434	115/135 (85%)
		Vps4_C	<570..603	CDD:286426	15/32 (47%)
KATNA1	NP_008975.1	Interaction with microtubules	1..185		64/240 (27%)
		Interaction with dynein and NDEL1. /evidence=ECO:0000250	1..75		29/68 (43%)
		Interaction with KATNB1. /evidence=ECO:0000269|PubMed:10751153	1..29		15/22 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..185		31/156 (20%)
		AAA	241..382	CDD:214640	120/140 (86%)
		AAA	245..381	CDD:278434	115/135 (85%)
		Vps4_C	<456..489	CDD:286426	15/32 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157798
Domainoid	1	1.000	241	1.000	Domainoid score	I2243
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1255
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59967
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm40614
orthoMCL	1	0.900	-	-		OOG6_102233
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5542
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800