DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kat60 and katnal1

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_004912098.2	Gene:	katnal1 / 100489961	XenbaseID:	XB-GENE-984420	Length:	540	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	294/558 - (52%)
Similarity:	366/558 - (65%)	Gaps:	77/558 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 AKTTFEEICENAKLARDMALTGNYDSACIYYEGLQGLLARQLKATADPLRKGKWSMINQQISQEH 120
            |:....|||:|||..|:.||.|||||:.:||:|:...:.:..:...||:.|.||..:.|::.:|:
Frog    52 ARMNLAEICDNAKKGREYALLGNYDSSMVYYQGVIQQIQKHFQTIRDPVVKVKWQQVCQELVEEY 116

  Fly   121 AKIKAIQRTLQDISLDLQSTKFAHKLRHQLSEESTTSKDPSAWFKPDPDIWTPPPKDPDVWGPPK 185
            .::|:|..||:...::..:     :....::||                    |.|||.||.||.
Frog   117 EQVKSIVSTLESFKIEKPA-----EFPVAVAEE--------------------PVKDPAVWPPPV 156

  Fly   186 P-----PPTTQAVGRRAAPNNRRTTPATQNSRPSSTIPQSTARNGPASTRNSRNSTSATAPSGGA 245
            |     ||..:...|...| .|:.:|..|...|       ..|..|.|        .:..||
Frog   157 PAEHRAPPQVRRPNREVKP-LRKESPGIQPHGP-------VGRAQPIS--------KSDRPS--- 202

  Fly   246 RTTNGRAGGRKLSTSNTNEARDDDSTAAGNNGGAAGDGENGDPQAAQEEERKFQPNNHIEAELVD 310
             ..:||..|:             |.....|...|..||          |.:||....: :.:||:
Frog   203 -NRDGRVRGK-------------DDKGRKNQQDAGADG----------ELKKFDGAGY-DKDLVE 242

  Fly   311 ILERDILQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTML 375
            .|||||:.::|.|.|.|||||.|||:||.|||||||.|||:||||||||||||||||||||||||
Frog   243 ALERDIISRNPNVHWEDIADLEDAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTML 307

  Fly   376 AKAVATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEH 440
            |||||||||||||||||:||||||||||||:|||||||||||||:|||||||||:|||||:..||
Frog   308 AKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH 372

  Fly   441 EASRRVKSELLVQMDGVGG---GEEQAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGRE 502
            |||||||||||||||||||   .::.:|:||||||||||||||||||||||||||||||:..||.
Frog   373 EASRRVKSELLVQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTANGRA 437

  Fly   503 ALLKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEV 567
            .|||||||||:::.||||..:|.:::||||||||||||:||||:|||:|.||||||||.|:.:|:
Frog   438 ELLKINLREVELEPSVDLEVIAQKIEGYSGADITNVCRDASMMAMRRRIQGLTPEQIRALSKDEL 502

  Fly   568 DLPVSNKDFNEAMSRCNKSVSRADLDKYEKWMREFGSS 605
            .:||:..||..|:.:.:||||.|||:||||||.||||:
Frog   503 QMPVTVMDFELALKKVSKSVSAADLEKYEKWMAEFGSA 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	21/84 (25%)
		P-loop_NTPase	325..>381	CDD:304359	49/55 (89%)
		AAA	358..496	CDD:214640	124/140 (89%)
		AAA	362..495	CDD:278434	119/135 (88%)
		Vps4_C	<570..603	CDD:286426	19/32 (59%)
katnal1	XP_004912098.2	RecA-like_KTNA1	259..428	CDD:410930	147/168 (88%)
		AAA_lid_3	452..496	CDD:407720	32/43 (74%)
		Vps4_C	<500..538	CDD:401324	20/37 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12942
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1207
OMA	1	1.010	-	-		QHG59967
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	1	1.000	-	-		FOG0002772
OrthoInspector	1	1.000	-	-		otm47792
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5542
SonicParanoid	1	1.000	-	-		X1862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110