DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kat60 and katnal2

DIOPT Version :9

Sequence 1:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001090643.1	Gene:	katnal2 / 100036615	XenbaseID:	XB-GENE-5827282	Length:	542	Species:	Xenopus tropicalis

Alignment Length:	478	Identity:	186/478 - (38%)
Similarity:	267/478 - (55%)	Gaps:	56/478 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 FKPDPDIWTPPPKDPDVWGPPKPPPTTQAVG--RRAAPNNRRTTP----ATQNSRP-SSTIPQST 221
            |:..|.| |....|.|.....||    ::.|  |||..|:.:..|    .|...|| |.:..::.
Frog    83 FQKYPKI-TKKALDHDSRVQSKP----RSAGKLRRAGSNSTQGLPRIAQQTVLHRPVSGSYFRTH 142

  Fly   222 ARNGPASTRNSRNSTSATAPSGGAR---------TTNGRAG-GRKLSTSNTNEARDDDSTAAGNN 276
            |.....|..||:......:|...:.         .|:|..| .|:....:......|  |..|.:
Frog   143 AHQKALSRENSKQENGGNSPREASEIGLNVSAISKTSGEGGQTRRRQVIDFRSMIQD--TIKGAS 205

  Fly   277 GGAAGDGENGDPQAAQEEERKFQP------NNHIEAELVDILERDILQKDPKVRWSDIADLHDAK 335
            ...|.:..|.:|..:   ||..:|      .|....||..::.|||..::|.|||.||..|..||
Frog   206 QEIALNSLNCNPDPS---ERLIKPVGAFIGGNSEMRELAAVISRDIYLQNPNVRWDDIIGLDAAK 267

  Fly   336 RLLEEAVVLPMLMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSATLTSKYR 400
            ||::||||.|:..|..|.||..||||:|:.||||||||:|||||||||.|||||:|::|:.||:|
Frog   268 RLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECNTTFFNISASTIVSKWR 332

  Fly   401 GESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGS--ESEHEASRRVKSELLVQMDGVGGGEEQ 463
            |:|||:||:|||:||::||||||:||::|:.|:||:  ..|||.|||:|:||||||||:...::
Frog   333 GDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTGPGGEHEGSRRMKTELLVQMDGLARSDD- 396

  Fly   464 AKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPSDEGREALLK------INLREVKVDDSVDLTY 522
              :|.||||:|.||::|.|:.|||||||.:.|||.|.|:|:::      .|...|::...:|.:.
Frog   397 --LVFVLAASNLPWELDYAMLRRLEKRILVDLPSKEARQAMIQHWLPPVSNSSGVELRTDLDYST 459

  Fly   523 VANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDLP------VSNKDFNEAMS 581
            :..|..||||:||..||:||:|..:|:....|....     :|..:||      |:..||.|.::
Frog   460 LGAETDGYSGSDIRLVCKEAAMRPVRKIFDALENHH-----SEHKNLPVISLDTVTTSDFLEVLA 519

  Fly   582 RCNKSVSRADLDKYEKWMREFGS 604
            . .|..:::..:||..|.:||.|
Frog   520 H-TKPSAKSLAEKYAAWQKEFES 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693	23/85 (27%)
		P-loop_NTPase	325..>381	CDD:304359	35/55 (64%)
		AAA	358..496	CDD:214640	87/139 (63%)
		AAA	362..495	CDD:278434	83/134 (62%)
		Vps4_C	<570..603	CDD:286426	10/38 (26%)
katnal2	NP_001090643.1	LisH	25..57	CDD:128913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..126		10/35 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..168		5/25 (20%)
		SpoVK	<245..526	CDD:223540	141/289 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920