DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gukh and WAVE5

DIOPT Version :9

Sequence 1:	NP_732393.1	Gene:	gukh / 53563	FlyBaseID:	FBgn0026239	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_193595.3	Gene:	WAVE5 / 827594	AraportID:	AT4G18600	Length:	2028	Species:	Arabidopsis thaliana

Alignment Length:	1934	Identity:	358/1934 - (18%)
Similarity:	614/1934 - (31%)	Gaps:	605/1934 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PALGRIASA-PQSPTA--GSSKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAV 175
            |.:.|.||. .:.|.|  |:.:|..           |...||||..|...::::|:.||.::...
plant    17 PEIQRSASVEDEEPKAILGAVEVAG-----------LIGILRQLGDLAEFSAEVFNGLQEEVTVT 70

  Fly   176 GERAGRVQRKIAAVERRVCAYDPKTVTVPESDLLTFAQRKH-HF--ETDKSFQQELFTGETR--- 234
               |.|.|:..:.|.|...|..|....|       .:|..| ||  .....:...:..|.:.
plant    71 ---ASRCQKLTSRVRRIESALSPLEKAV-------LSQTSHIHFAYTAGSEWHPRIRNGHSHFVQ 125

  Fly   235 ---PLSVRQLYTEAGKELPV------ATGATATALASL-------------------------AH 265
               ||.|.:.|.:.....|:      |.|...:.|...                         ||
plant   126 SDLPLCVMESYEQCRDPPPLHLLDRFAVGGPGSCLRKYSDPTFFRKELSNPSKTDDIKVQRDQAH 190

  Fly   266 ---SQSLIPSRSISFNGEVLSSDHEVLQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLP 327
               .:..:|.|:|..:..|.:||    :.||:     ||...:|    :|...:|..:.:::...
plant   191 RKRKKKRLPQRNICRSNAVSTSD----ETNGA-----HLSSFTD----DRPTTSRSTSTVDMPRS 242

  Fly   328 AAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGILTPALSPSVLSADAVDALYAQN 392
            :.::||                                                :|.||..|.|.
plant   243 SNMQDL------------------------------------------------SDIVDQSYLQG 259

  Fly   393 LSQAADSSRHNHHTQALIPNDINKDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCA 457
            .|.|.:.|      :|.:.:|                                      ||....
plant   260 QSGAQEQS------EAQVQSD--------------------------------------FQESSK 280

  Fly   458 ARKSTSG----------------------GYAGGA--TAGSSSSTSPENAGQTEGNNLDDNV--- 495
            ||.|.:|                      |:..|:  .|....||.||...:.    :|||:
plant   281 ARDSITGSGYIEYVINQSPVDKPEVKLVEGFLSGSLCPADRIGSTVPEGCIEV----VDDNILYS 341

  Fly   496 --QTVSRRSRSRKVRGKRRNTIAGIDQKEIQDAANGNGESKNASNATSPVAPAQQAETTSSDAKK 558
              :.:...|.|.....|:....:.:::....|..:...|||     ..||.| .:......|..:
plant   342 PSEDLLVPSASNVCDEKKETLESMVEKSRKDDEPSELHESK-----FGPVTP-DRVRQNQRDFDR 400

  Fly   559 S-----------KKFGRSKSSDI-------------LKKESAALPYDKGKSTLTRLNSLKQWGRN 599
            :           :|..:|::::|             .::||.|..:...::|:...:.....|..
plant   401 TYILFDEVDIVGEKQSKSQANNIDGTLGIENEGEDKSEQESEADEFVDARNTIESESESDIDGVP 465

  Fly   600 RFKFMHRTGELGDQLDTSGCSSQNSSAEKADSHHGS-----------PAGDNSKRDIDDECVVHH 653
            :.|..|..|::     ::.||...:|    |::.||           |..:||:   |:.|...:
plant   466 KPKLEHYFGDI-----STYCSEDANS----DNNDGSEDITYEEMAHDPRHENSE---DESCSGSY 518

  Fly   654 LVAQKS----------ESRFSHERKPSYSSSEKSISVSSSGQLRGRLQLSSGPMAAAHVKMRETA 708
            |....:          |....|:     .:|:|....           .:..|...|. |.....
plant   519 LPEDSNVSSCLSDPVCEETLFHD-----ENSQKPWEF-----------FTMCPSLLAE-KAVPDV 566

  Fly   709 TLNRQRRNGLHAL-AGKEEQPHSSSGNWSASSESGRASIGSEITMQPKSSASSTSLNV---SSFQ 769
            |:.|:.....|.| ||.......||.....|..|.:.:|.:|..:..:...:..||..   ....
plant   567 TILREEPVMAHPLFAGDSANEKISSEERIISCPSLKDAIPAEKILPEEHLVNYPSLEAIPHEKIL 631

  Fly   770 PGGAGSGPPS--SMLSRRRFLN-TSASSSVTSEGTATPELQAEAGAYPGHLDDETSSAYSCDTEG 831
            ||.:.:..||  .::.:.:.|: .|...:|....|...|..|...::|..:.|:..|....|::.
plant   632 PGESIAKYPSFAEIIPQEKILSEKSLEEAVLDNMTPAGEPDAAHPSFPKAVQDKKISPEVLDSKI 696

  Fly   832 Y---------------YTSFH-------MDSGLRTLKEEEPS-------VMPGTPL--QTSLHTS 865
            :               :...|       .|.  |.|.||.||       .||...|  :.:|.:|
plant   697 FSVPKAVSQEPISLEEFVRIHPCLAEAVPDE--RFLIEEPPSTCLSLTKAMPTEILLPEKTLESS 759

  Fly   866 SYSFGSQSNQTVL---NAESEYELFGRGSTSTTTSSAGTVCTALMSGAASGPDVPERSSSLGKHS 927
            .| ......:.:|   :.:|.:....:.:..|..|......|.|....|    ||:...||.:..
plant   760 HY-LEELPEEDILQEKSVDSTHPSCAKAAAETNLSPEVLDSTKLSVAEA----VPQEQVSLEEFV 819

  Fly   928 GQSRSQSTSASSSTL-----ERSYSSSTIGSTLERTGTIKRNVKMSPTKAGGEVTEKDDQQDQ-- 985
            |.:.....:.....|     :.:|.|.|....:|:. ..:..::..|:.|  |:.|::..|::
plant   820 GINPCLVEAVPDERLLPEEPDTTYLSLTKAVAIEKV-LSEELLETYPSLA--ELPEEEFLQEETD 881

  Fly   986 ----------DQQQQLEFSESSD--LEGVERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQTN 1038
                      |::...|.|:|::  ||....:|.|..:..:..    ..|::  ..:.::.....
plant   882 DATHTSEAVSDEEISQEVSDSTNLSLEEALPLEHISHEEFVGI----DQCLV--EVAPEERFLPE 940

  Fly  1039 DPNRTLTSLTIDVEHGEQDEDEAEQKTP-TNSKDHNLNELKQTPTKALSGMFEKLRVKLVPGKSS 1102
            :|..|..|||:        |....:|:| |......|.|.|....:|...|...|...:...:||
plant   941 EPVITCLSLTM--------EGVLSEKSPETYPSLSELPEEKILDEEADDAMHPCLSEAVSDEQSS 997

  Fly  1103 P------------AKNQMQPK--------PANSSAVNDDELYDLAGEYVTIADISNNNNNNKNIG 1147
            |            |..|.|..        |....||.|  :.||..|::|..
plant   998 PNVLGSTNSPVAEAVPQAQISVEEFVGIDPCLVEAVPD--MRDLPEEHITSC------------- 1047

  Fly  1148 RRNTGMGIYYSNDIVSKRVEPSTSAVSEYVSLNELP------------------------QHLRR 1188
                   ||.:|.:..:.|.|. .......||.:||                        :|:..
plant  1048 -------IYLTNVVPIEEVLPE-EPFEACASLGKLPKDKISQEESDEATHTLSCAKAESDEHVSL 1104

  Fly  1189 HAVSSRSAPAAES------------------------ESCAQQQLPVEPAAATSQPPPLPLGGRT 1229
            ..::|.:..|||:                        |....:||.....:.|...|.:.:...
plant  1105 EVLNSTNLSAAEAIPNEQVTLDEFVGIDPCLGEVVLDEEVLPEQLDTTCRSLTKAAPIMTIFPE- 1168

  Fly  1230 QGVGDGVPMYAEIGELSEEK-------------------------PLASAANRRLRPNAEGKLVY 1269
                :...:|..:.||.|||                         ||....:  ..|:.|..:.|
plant  1169 ----EPPEVYPSLEELPEEKIAQEEEVDDATHPYFSEAVCDEKIPPLEDPGS--THPSLEESVPY 1227

  Fly  1270 DSDSLKRRKGAHTTFAPGPYVKETESALHSAESAAAAIASSQDPS----AASGAISSTKS---AK 1327
            :..|.:...|.:      |::   |||..:      .|....:|.    :::.|:|..|:   ..
plant  1228 EEASHEELVGTN------PFL---ESAFPN------EIGFPDEPGVTYRSSAEAVSKEKNLPEES 1277

  Fly  1328 LLLLTSGGLISGNRKVA-----NVRPIVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYET 1387
            |....|...:..:.|::     :..|..|::....|:|......:|:...::    |:|.|  |.
plant  1278 LPTYPSWAEVVPDEKISREELDSTYPSSAEAVFDENISGSEAPGSTTETGRQ----NKTFP--EK 1336

  Fly  1388 IAAPVANLMMPSPSGKSNSSTGSTATSSSSSASGQSGEEGY--QRFSN--IYEQVQP---APSTQ 1445
            ..|...:|.......|...|..||:|:.:...:....||.:  :.|.|  ::::..|   ||.:.
plant  1337 TFATENSLNEAVFDEKIPGSEASTSTTETGPHNKTFPEEPFAMENFLNEAVFDEKIPGSEAPVST 1401

  Fly  1446 PQ---------EDATATPFQRSAPIYWTLQNRRSQPRPQPAG--------NVTCRDDLYAT--PI 1491
            .:         |:..||....:..::..:     .|..:..|        |.|..:..:||  .:
plant  1402 TETGLHNETFTEEPVATDISLNEAVFGEI-----IPGSEAPGSATETGLHNKTFPEKPFATDLSL 1461

  Fly  1492 RRA---DRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFLTSTP-------TRSG----EGERD 1542
            :.|   :::|...|:::.|....:....    ||......|:||.       |.||    ..|..
plant  1462 KEAVFDEKIPGSEASSSTTETSPHNKTF----PRETITTDLSSTEAVFDEKITGSGVPSFTTETG 1522

  Fly  1543 SENTQLPPMKQPSRNWTDDAPERLN-TCADRIGQSKTTLMDFKKLLLAKS---AKASPVQRKVSA 1603
            |.|...|....|..|.....|.... ..|:.|...|..|.|...||.|::   .|.|| :...|.
plant  1523 SHNKCFPEEPVPKENILPKEPAAAYLALAEGIPDQKVFLDDAALLLFAEAIFDQKFSP-EVPDST 1586

  Fly  1604 VELLKKPAQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFANRRMLRQGQFGSP 1668
            ...||:|....|.|.||.            ..|..|..:|..::...|.|.::..|.::.....|
plant  1587 YPSLKEPEMHVAAPCVVT------------DLPAKNIKVKEGEVHNEPYTASDVSMNQKSGLLEP 1639

  Fly  1669 ---SKTFAPKMRGPVNMVAAAAAPPRTDIMSTTIPEANSEEDHSNTSGG 1714
               .:|| |...|.|.:      .|.|   ..::|...|.|..|..|.|
plant  1640 ESTERTF-PSSGGTVTI------SPDT---QNSLPNGTSVESISIWSNG 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	6/49 (12%)
WAVE5	NP_193595.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12902
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100