DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gukh and SCAR2

DIOPT Version :9

Sequence 1:	NP_732393.1	Gene:	gukh / 53563	FlyBaseID:	FBgn0026239	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_181378.2	Gene:	SCAR2 / 818425	AraportID:	AT2G38440	Length:	1399	Species:	Arabidopsis thaliana

Alignment Length:	1693	Identity:	316/1693 - (18%)
Similarity:	517/1693 - (30%)	Gaps:	593/1693 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 TRHQSQSLPNSRHPSQQRPALGRIASAPQSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVLI 160
            ||:||::......|...:      |:....|.|         ..:.::...|...||||..|...
plant     4 TRYQSRNEYGLADPDLYQ------AADKDDPEA---------LLEGVAMAGLVGILRQLGDLAEF 53

  Fly   161 ASDIFDDLQRDLQAVGERA----GRVQR---KIAAVERR-VCAYDPKTVTVPESDLLTFAQRKHH 217
            |:::|.||..::.|...|:    .|||:   :..::|:. :|..|....         |:.:...
plant    54 AAEMFHDLHEEVMATASRSHGLMARVQQLEAEFPSIEKALLCQTDHSPF---------FSNKGVE 109

  Fly   218 FETDKSFQQELFTGETRPLSVRQLYTE-----------------AGKELPVATGATATALASLAH 265
            :..:...:|.:.|....|..|...|.|                 ||..|...|..:...|.:.::
plant   110 WHPNLQLEQSVVTSGDLPRCVMDSYEECRGPPRLFLLDKFDISGAGACLKRYTDPSFVRLETSSY 174

  Fly   266 SQSL-----------------------IPSRSISFNGEVLSSDHEVLQLNGSTDTEDHLLCVSDF 307
            .:|.                       .|..::|.:.::    ||:.       .|:||
plant   175 EESWDDIQREKKSQKAKRRASQWRNGGTPENALSSHAKL----HELF-------LEEHL------ 222

  Fly   308 GNANRKLRTRIDAEIEIRLPAAIEDL--RKWTSSEAL---GDVTVTPDCMHHVDTSVSTSLAIGE 367
                         |.....||.:..|  ||......:   |:..:.......||:.:|..:....
plant   223 -------------EAHHSDPARVVKLKTRKLDGCSLISKSGESYMEKFVQTRVDSKISYEIITQN 274

  Fly   368 NGILTPALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPNDINKDVPLNHRLPSPEEQTK 432
            .|:||                  .|:    ||:|           |:..|:|
plant   275 PGLLT------------------WNM----DSAR-----------DVVTDIP------------- 293

  Fly   433 QIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQT--EGNNLDDNV 495
                    |:..|....|..               ||:.|..|..:..||....  .|..::.::
plant   294 --------EISMVGAMDKSH---------------GGSRAEVSFPSEQENVANVNMNGGFIEKDI 335

  Fly   496 QTVSRRSRSRKVRGKRRNTIAGIDQKEIQDAANGNGESKNASNATSPVAPA--QQAETTSSDAKK 558
            :||. .|...:|||   .||.    ::.|...||.              |.  ||
plant   336 ETVP-ESTYNEVRG---TTIT----QDSQTVLNGK--------------PGFFQQ---------- 368

  Fly   559 SKKFGRSKSSDILKKESAALPYDKGKSTLTRLNSLKQWGRNRFKFMHRTGELGDQLDTSGCSSQN 623
                 ||.|.|:
plant   369 -----RSYSEDL----------------------------------------------------- 375

  Fly   624 SSAEKADSHHGSPAGDNSKRDIDDECVV-----------HHLVAQKSESRFSHERKPSYSSSEKS 677
              ..:||::..:||...|:.:.||||..           ||:.:...|.|.....:.|:|.|..:
plant   376 --TSEADNYVDAPATMESETETDDECRPKSRSDTLKDGNHHIYSDAVEERMEDPPQFSFSHSNGN 438

  Fly   678 ISVSSSGQLRGRLQLSSGPMAAAHVKMRETATLNRQRRNGLHALAG--------KEEQPHSSSGN 734
            ..||.:|:       ||....:......:||:::...::....|:|        |.|...|.|
plant   439 TPVSENGR-------SSFGKKSTSYSYSDTASISIDDQSDGEKLSGCLPSTSSFKSELVDSMS-- 494

  Fly   735 WSASSESGRASIGSEITMQPKSSASSTSLNVSSFQPGGAGSGPPSSMLSRRRFLNTSASSSVTSE 799
             ..:.|:.:.|  .::.:|...|:|:.....|....|...|..|.|...:...|...:.:|...|
plant   495 -HVTPEANKVS--HDLNVQESVSSSNVDGQTSLSSNGTCSSPRPVSQNDQSCSLTVQSLASEVVE 556

  Fly   800 GTATPE---LQAEAGAYPGHLDDETSSAYSCDTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTS 861
              .:||   |....|...|...|...|:.||      .||  |:....|..|..|:
plant   557 --TSPELVRLDLMKGGNDGRKVDPFDSSKSC------ASF--DAKNSDLPSETSSI--------- 602

  Fly   862 LHTSSYSFGSQSNQTV----------LNAESEYELFGRGSTSTTTSSAGT--------VCTALMS 908
               ||.|.||:.:.|:          :|:.:..:.|....|......|.|        .|:.:::
plant   603 ---SSTSEGSRCDSTIEKNCMVASNLVNSGTSPQAFVDSQTGKQLPIADTDFETNSIVACSEVLA 664

  Fly   909 GAASGPDVPERSSSLGKHSGQSRSQSTSASSSTLERSYS-SSTIGSTLERTGTIKRNVKMSPTKA 972
            .:.|.|:..:.....||....|.......|..|..:... ||..|..|:.|...:.:. :|.|..
plant   665 NSGSDPEERDGRCLTGKLVPCSAGVGMEVSPDTPSKVCGPSSADGIHLKDTLDDETDC-VSVTNV 728

  Fly   973 GGEVTEKDDQQDQDQQQQLEFSESSDLEGVERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQT 1037
            ..:|..|:...|...|     |..:|::....:..|                       .|||..
plant   729 VVDVDSKNSVADVGSQ-----SSVADIDSQSSVAEI-----------------------SDEHSC 765

  Fly  1038 NDPNRTLTSLTIDVEHGEQDEDEAEQKTPTNSKDHNLNELKQTPTKALSGMFEKLRVKLVPGKSS 1102
            ...|      |.||...|..||..|......| |.|            ||: |||     .|.:|
plant   766 AFGN------TADVSVSESHEDTLENGMSVPS-DFN------------SGV-EKL-----AGDAS 805

  Fly  1103 PAKNQMQPKPANSSAVNDDELYDLAG-EYVTI-------ADISNNNNNNKNIGRRNT-------G 1152
            |..::.      ...::.:..:||:| :..|.       .|:|:|:|:..:.|..:.       |
plant   806 PTCSKC------DDHISHEGFHDLSGLDNATTDIVPNVELDVSDNDNDTSSGGVNHAVSLSSTRG 864

  Fly  1153 MG--------IYYS--------NDIVSKRVEPSTSAVSEYVSLNELPQHLRRHAVSSRSAPAAES 1201
            .|        .|.|        :|.|   ||...:.:.:....:|:..|.....|||      |.
plant   865 KGSLPWISTNTYQSSSDAGEIFHDTV---VESDGTLLEDNNPESEIKMHKSPLEVSS------EG 920

  Fly  1202 ESCAQQQLPVEPAAATSQPPPLPLGGR---TQGVGDGV--------------------------- 1236
            .|.......||...:||..|.|....|   |:..|:.:
plant   921 LSTEPDNKDVESIESTSPKPSLDQRNRDTETKSPGESILDDNCIDSTQVYNLNLLESEAIDQAVR 985

  Fly  1237 --PMYAEIGELSEEKPLASAANRRL--RPNAEGKLVYDSDS----LKRRKG-------------A 1280
              ..||. .|:::|:.|.|...|.|  .|.:.| |.:...|    |.|.|.             .
plant   986 EQTSYAS-HEVADEELLQSNVFRGLEFEPQSAG-LEFAPQSAGIELNRPKQELNLDPTFPSFGFI 1048

  Fly  1281 HTTFAPGP----------------------YVKETESALHSAESAAAAIASS------QDPSAAS 1317
            ..|..|.|                      ::.|:.....||.|||..|.||      ..||..|
plant  1049 PETIPPNPEDMPPLPPMQWLIGKVPHSFPTFMGESVETSSSALSAAPPIGSSLNVQIGSPPSELS 1113

  Fly  1318 GAISSTKSAKLLLLTSGGLISGNRKVANVRPIVAKSPLSRNV---------------SEMATYQA 1367
            .::.|.:|.:|    .||.:..          .::.||..::               ||:.|
plant  1114 VSLGSDESERL----PGGFVHN----------ASEKPLQSSIQFPTMSTDLNSQYDSSELPT--- 1161

  Fly  1368 TSYQ--------DQKQLLANRTNPFYETIAAPVANLMMPSPSGKSNSSTGSTATSSSSSASGQSG 1424
            ..||        ::..|||:.....:|.:.:..::|.:|....:..........|.|||......
plant  1162 IPYQECIEDFGSEENNLLADHAAQNHELVYSQASSLQLPQVKHEDFKDDADVHESQSSSDDHHCP 1226

  Fly  1425 EEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTLQNRRSQPRPQPAGN----VTCRD- 1484
            |.         :.:.|..||:.::...:.|...:|....:......:..|...|:    |:|..
plant  1227 ET---------KSLTPTQSTKVEDKGHSVPDASNAETAESSNTSVQKINPVSVGDAMWPVSCFSV 1282

  Fly  1485 ----DLYATPIRRADRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFLTSTPTRSGEGERDSEN 1545
                |.|.|.:....|||||.:......|..:|..:..:       :.:...|.:|.:.::||..
plant  1283 APTLDTYKTEVVPTVRLPRPRSPLVDAVAAHDRRKMKKV-------SEMVHPPIKSKQDDKDSLL 1340

  Fly  1546 TQL 1548
            .|:
plant  1341 AQI 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	7/27 (26%)
SCAR2	NP_181378.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12902
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100