Protein Alignment gukh and NHSL1

DIOPT Version :9

• Sequence 1: NP_732393.1
• Gene: gukh / 53563
• FlyBaseID: FBgn0026239
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: XP_011534268.1
• Gene: NHSL1 / 57224
• HGNCID: 21021
• Length: 1672
• Species: Homo sapiens
• Alignment Length: 1585
• Identity: 318/1585 - (20%)
• Similarity: 532/1585 - (33%)
• Gaps: 489/1585 - (30%)

  Fly   412 NDIN------KDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGA 470
            :|:|      |.:|    ||:|||:.:|.|....|:|:.:|.:|::|.|..:.|:|.
Human   205 SDLNTQTNWTKSLP----LPTPEEKMRQQAQTVQADVVPINITGENFDRQASLRRSL-------- 257

  Fly   471 TAGSSSSTSPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGID---QKEI-----QDAA 527
                                    :.|.:...|.:||  |||.||.|:.   |||:     ||.|
Human   258 ------------------------IYTDTLVRRPKKV--KRRKTITGVPDNIQKELASGTGQDDA 296

  Fly   528 NGN-----------------------GESKNASNATSP---VAPAQ---QAETTSSDAKKSKKFG 563
            :|:                       .|::::|..|..   |.|:.   :|:.....|.:...|.
Human   297 DGHSVYTPDHYSTLGRFNSCRSAGQRSETRDSSCQTEDVKVVPPSMRRIRAQKGQGIAAQMGHFS 361

  Fly   564 RSKSSDILKKESAALPYDKGKSTLTRLNSLKQWG--RNRFKFMHRTGELGDQLDTSGCSSQNSSA 626
            .|..:..:..:||.:.:.....:....:||.:.|  .|......|.|.||...|.:|........
Human   362 GSSGNMSVLSDSAGIVFPSRLDSDAGFHSLPRSGARANIQSLEPRLGALGPAGDMNGTFLYQRGH 426

  Fly   627 EKAD---SHHGSPAG--------DNSKRDIDDECVVHHLVAQKSESRFSHERKP--SYSSSEKSI 678
            .:||   .|.|..:|        ....|..:.|.::.........:.:|....|  :.|||.:.|
Human   427 PQADENLGHLGGASGTGTLLRPKSQELRHFESENIMSPACVVSPHATYSTSIIPNATLSSSSEVI 491

  Fly   679 SVSSSGQLRGRLQLSSGPMAAAHVKMRETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSESGR 743
            ::.::.....|...|||   ::|.:::     :|......||:.|   .|.|...:|:    .|.
Human   492 AIPTAQSAGQRESKSSG---SSHARIK-----SRDHLISRHAVKG---DPQSPGRHWN----EGH 541

  Fly   744 ASIGSEITMQPKSSA---------SSTSLNVSSFQPGGAGSGP------------PSSMLSRRRF 787
            |:|.|: .:.|.|..         |:..||..:.:..|:.:.|            |..:..:...
Human   542 ATILSQ-DLDPHSPGEPALLSLCDSAVPLNAPANRENGSQAMPYNCRNNLAFPAHPQDVDGKSES 605

  Fly   788 LNTSASSSVTSE---------GTATPELQAEAGAYPGH-----------LD-----DETSSAYSC 827
            ..:......:||         |.|:| |:... |.||:           ||     ::..|.||.
Human   606 SYSGGGGHSSSEPWEYKSSGNGRASP-LKPHL-ATPGYSTPTSNMSSCSLDQTSNKEDAGSLYSE 668

  Fly   828 DTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTSLHTSSYSFG-------------SQSNQTVLN 879
            |.:||..|.|.|||..:               .:|..||..||             :|.||   .
Human   669 DHDGYCASVHTDSGHGS---------------GNLCNSSDGFGNPRHSVINVFVGRAQKNQ---G 715

  Fly   880 AESEYELFGRGSTSTTTSSAGTVCTALMSGAASGPDVPERSSSL---GKHSGQSRSQSTSAS-SS 940
            ..|.|:   ..|.|...|         :..|...|..|.|:.||   .|.|.|...|..:.| .:
Human   716 DRSNYQ---DKSLSRNIS---------LKKAKKPPLPPSRTDSLRRIPKKSSQCNGQVLNESLIA 768

  Fly   941 TLERSYSSSTIGSTLERTGTIKRNVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLE----- 1000
            ||:.|...|.                  |.|:|...::               |..||||
Human   769 TLQHSLQLSL------------------PGKSGSSPSQ---------------SPCSDLEEPWLP 800

  Fly  1001 ---GVERIERIKQKTALTSKRIPSMCIITPTTSDDD--EHQTNDPNRTLTSLTIDVEHGEQDEDE 1060
               ....:......|:.|:..:.|:|..||:.||..  :.:..||    ....||....::|...
Human   801 RSRSQSTVSAGSSMTSATTPNVYSLCGATPSQSDTSSVKSEYTDP----WGYYIDYTGMQEDPGN 861

  Fly  1061 AEQKTPTNSKDHNLNELKQTPT--KALSGMFEKLRVKL--VPGKS------SPAKNQMQPKPANS 1115
            ......|:|         ..||  ..:..:.|..|..:  |||.|      ||.|:.....|::.
Human   862 PAGGCSTSS---------GVPTGNGPVRHVQEGSRATMPQVPGGSVKPKIMSPEKSHRVISPSSG 917

  Fly  1116 SAVNDDELYDLAGEYVTIADISNNNNNNK---NIGRRNTGMGIYYSNDIVSKRVEPSTSAVSEYV 1177
            .:...:....|....|.:..:|..|...|   .:..|.:.:       |.|..:..|::::|...
Human   918 YSSQSNTPTALTPVPVFLKSVSPANGKGKPKPKVPERKSSL-------ISSVSISSSSTSLSSST 975

  Fly  1178 SLNELPQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATSQPPPLPLGGRTQG-------VGDG 1235
            | .|....:::...:..|.||...........|.....:...|||.|:...:||       |...
Human   976 S-TEGSGTMKKLDPAVGSPPAPPPPPVPSPPFPCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPP 1039

  Fly  1236 VPMYAEIGELSEEKPLASAANRRLRP--NAEGKLVYDSD-SLKRRKGAHTTFAPGP-------YV 1290
            .|..|.|       |..|..:..|.|  .|...::.||. ||........:..|.|       ::
Human  1040 PPPEALI-------PFCSPPDWCLSPPRPALSPILPDSPVSLPLPPPLLPSSEPPPAPPLDPKFM 1097

  Fly  1291 KETESALHSAESAAAAIASSQDPSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRPIVAKSPL 1355
            |:|.....::....::..|.:.||..    ..|....:.|:|:..|     ::..:||:...|.
Human  1098 KDTRPPFTNSGQPESSRGSLRPPSTK----EETSRPPMPLITTEAL-----QMVQLRPVRKNSG- 1152

  Fly  1356 SRNVSEMATYQATSYQDQKQLLA--------------NRTNPFYETIAAPVA-NLMMPSPSGKSN 1405
                :|.|.....:.|:|:..:|              |.||.. |:.:.|.: ...:|:|:..|:
Human  1153 ----AEAAQLSERTAQEQRTPVAPQYHLKPSAFLKSRNSTNEM-ESESQPASVTSSLPTPAKSSS 1212

  Fly  1406 SSTGSTATS-----SSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTL 1465
            .....:|..     |.|..:..:||          .:.:|:|||.|..|  ::|.::..||
Human  1213 QGDHGSAAERGGPVSRSPGAPSAGE----------AEARPSPSTTPLPD--SSPSRKPPPI---- 1261

  Fly  1466 QNRRSQ-----PRPQ------PAGNVT---------------------------CRDDLYAT--- 1489
             :::.:     |.||      ||.||:                           .:...:||
Human  1262 -SKKPKLFLVVPPPQKDFAVEPAENVSEALRAVPSPTTGEEGSVHSREAKESSAAQAGSHATHPG 1325

  Fly  1490 ---------------------PIRRADRLPRP-------------------------VAAAAATA 1508
                                 |:.:.|..|.|                         .|....|.
Human  1326 TSVLEGGAAGSMSPSRVEANVPMVQPDVSPAPKQEEPAENSADTGGDGESCLSQQDGAAGVPETN 1390

  Fly  1509 AEGNRSNISPIVPRNRSGAFLTSTPTRSGE--------------GERDSE------NTQLPPMKQ 1553
            |.|:.|.....:..:.:...:|.:..|:.|              |.|||:      ::..||:..
Human  1391 AAGSSSEACDFLKEDGNDEVMTPSRPRTTEDLFAAIHRSKRKVLGRRDSDDDHSRNHSPSPPVTP 1455

  Fly  1554 PSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKP----AQAT 1614
            .....:..:|:::.:....|.:|.|:..:||.|||.|.:: |....::||.|:||..    .::.
Human  1456 TGAAPSLASPKQVGSIQRSIRKSSTSSDNFKALLLKKGSR-SDTSARMSAAEMLKNTDPRFQRSR 1519

  Fly  1615 ATPPVVKPSGPG----QKVASAGSKPTINTSL--KLLDLSG-------SPKTFANRRMLRQGQFG 1666
            :.|....|..|.    .|...|..:...|..|  :.|..||       :|.:.|:.|...:.:..
Human  1520 SEPSPDAPESPSSCSPSKNRRAQEEWAKNEGLMPRSLSFSGPRYGRSRTPPSAASSRYSMRNRIQ 1584

  Fly  1667 SPSKTFAPKMRG----PVNMVAAAA 1687
            |...|...:..|    ||:.:|..|
Human  1585 SSPMTVISEGEGEAVEPVDSIARGA 1609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	12/32 (38%)
NHSL1	XP_011534268.1	NHS	321..955	CDD:291922	148/727 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4798
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.050