DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gukh and nhsl1a

DIOPT Version :9

Sequence 1:NP_732393.1 Gene:gukh / 53563 FlyBaseID:FBgn0026239 Length:1788 Species:Drosophila melanogaster
Sequence 2:XP_005158876.2 Gene:nhsl1a / 566695 ZFINID:ZDB-GENE-050411-25 Length:1605 Species:Danio rerio


Alignment Length:1783 Identity:340/1783 - (19%)
Similarity:553/1783 - (31%) Gaps:648/1783 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 PAAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGILTPALSPSVLSAD-------- 383
            ||.:|||.:   ...:...||..:|    |..........:....:||.|.:.|...        
Zfish   127 PACVEDLHR---QAKVNLKTVLREC----DKLRKDGFRSSQYYSQSPAFSATSLCESVHLDEEKT 184

  Fly   384 --------AVDALYAQNLS----------QAADSSRHNHHTQALIPNDINK---DVP-----LNH 422
                    .:|.|....||          :|:||           ||:.:|   .:|     |.|
Zfish   185 EKKKKRFKVLDCLSQSCLSLCCHLRSWKTKASDS-----------PNEEDKLVYSMPPQTPLLEH 238

  Fly   423 --------------RLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAG 473
                          .||:|||:.:..|.....::|.:|.:|::|.|..:.|:|.:          
Zfish   239 GSDMDIQRSWTSCLPLPTPEEKMRLQAQSVATDIIPINITGENFDRQASFRRSMA---------- 293

  Fly   474 SSSSTSPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGI-DQKEIQDAANGNGESKNAS 537
                                |..|:.||.:    |.:||.||.|: |..:.:.|.....:|:..|
Zfish   294 --------------------NTDTIIRRPK----RVQRRKTITGVPDNIQTELANKEQADSRIHS 334

  Fly   538 NATSPVAPAQQAETTSSDAKKSK------------------KFGRSKSSDILKKESAALPYDKGK 584
            :...|.:...:..:.:|..|:|.                  :..|::....:..:.|::......
Zfish   335 SMADPYSTLSRVGSVNSTLKRSDTRDSCCQTEEVKIVPPSVRRIRAQRGHGIAAQMASVSSSSSI 399

  Fly   585 STLTRLNSLKQWGRN----RFKFMHRTGELGDQLDTSGCSSQNSSAEKADSHHGSPAGDNSKRDI 645
            ||::..|.:.....|    .|:.:.|.|....|..:.  :..|||..:|:|...||...:.....
Zfish   400 STISDCNGISYTQLNDSDQSFQSLPRQGSRIPQQHSE--TKYNSSPYRANSGSTSPLSYHFNMQH 462

  Fly   646 DDECVVHHLVAQKSESRFSHERKPSYSSSEKSISVSSSGQLRGRLQLSSGPMAAAHVKMRETATL 710
            |....:|.|    |:||.......:|..|:|: :.||...|.|.|| :|.|..           .
Zfish   463 DSSSSLHML----SDSRSKLTENLNYEGSDKN-NTSSLFSLSGALQ-NSIPYG-----------Y 510

  Fly   711 NRQRRNGLHALAGKEEQPHSS-----SGNWSASSES----GRASIGSEITMQPKSSASSTSLNVS 766
            .|...|.:       :.||||     |.:.|.|..|    ..||:.:.|..:.:|..|:..    
Zfish   511 KRTEDNQM-------QSPHSSVQLLNSEDASLSGVSSCYESTASLCTGIHTETESQCSTLD---- 564

  Fly   767 SFQPGGAGSGPPSSMLSRRRFLNTSASSSVTSEGTATPELQAEAG-------------AYPGHLD 818
                 |.....|:.:   ||..|.|.||:.:.....|.:...|..             ::..|.:
Zfish   565 -----GRNCCSPNCV---RRDSNFSESSNQSCSTLTTDQWTYEVSPKDNVTSSCSSPVSHIYHAE 621

  Fly   819 D------ETSSAYSCDTEGYYTSFHMDSGLRT--------------------------------- 844
            :      :|||.:|.|.||||||..:||||::                                 
Zfish   622 EHSPSKTDTSSLFSVDNEGYYTSMRLDSGLKSHSHGCINKAGEQKHSLYECKDHHSQSDTASLHS 686

  Fly   845 ----------LKEEEPSVMP-----------------GT------------PLQTSLHTSSYSFG 870
                      .|..:|.:.|                 |:            .||.:|:|.:.|..
Zfish   687 NRSLTRSISLRKARKPPLPPERTDSLRRKPQRKSRHSGSVLNEQLISSLQQSLQLNLNTQTTSCS 751

  Fly   871 SQS--------------NQTVL------------------------------------------- 878
            .||              :|:::                                           
Zfish   752 EQSPCGRFEDPWVLRPRSQSIISAASSGVSAPAAVCPVTPTHSDSSSQRSDYAESWDFYMDCPCP 816

  Fly   879 --------------NAESEYELFGRG-----------------------------------STST 894
                          :||..:.:.|..                                   |:.:
Zfish   817 RSDQSLSSQITRSASAEENHGVIGNASYNSKFPSSPFSNSQSKLTSSPDKVHRLTSPSSGYSSQS 881

  Fly   895 TTSSAGTVCTALMSGAASG----PDVPERSSSLGKHSGQSRSQSTSASSSTLER----------- 944
            .|.:|||..|:|:...:..    |.||||.|||   .....|.|||.||:|.:.           
Zfish   882 NTPTAGTPVTSLIRAKSPAGRPKPKVPERKSSL---RSSISSSSTSLSSNTSDSIRNIPPPPPLP 943

  Fly   945 --------SYSSSTIGSTLERTGTIKRNVKMSPTKAG---GEVTEKDDQQDQDQQQQLEF----- 993
                    |.||::...|..:...|.....:....:.   |:.|..|.....::....:|     
Zfish   944 DMTTALCGSPSSASFSPTAAKIDPIPSFTSLQDVSSALEDGQNTLSDTSATPEECDSPDFPPPHS 1008

  Fly   994 SESSDLEGVERIERIKQKTALTSKRIPSMCI------------------------------ITPT 1028
            :....|.|......:.....|..|  ||:||                              :|||
Zfish  1009 NVFESLSGNVDTNSLPPPPLLLCK--PSLCISSLLPPPPPPPPLLLETSLQPATILKTESSLTPT 1071

  Fly  1029 TSDDDEHQTNDPNRTLTSLTIDVEH-GEQDEDEAEQKTPTNSKDHNLNELKQTPTKALSGMFEKL 1092
            |:...|.:.|            :.| |||   |..|:....::...:.:|:....|.:..:|   
Zfish  1072 TAVKCEKEVN------------ISHTGEQ---EKTQRPIITAQALQMVQLRPVKLKQIETIF--- 1118

  Fly  1093 RVKLVPGKSSPAKNQMQPKPANSSAVNDDELYDL--AGEYVTIADISNNNNNNKNIGRRNTGMGI 1155
                    :|.:.:....:..|.|..|..:..::  .|:.||:..::.:.|:      ..|....
Zfish  1119 --------TSVSFDHSDHQAQNHSDTNSGKSLEIDNTGQTVTVNCVTQSENS------METSECE 1169

  Fly  1156 YYSNDIVSKRVEPSTSAVSEYVSLNELPQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATSQP 1220
            |..|..:....|.|||.:..     :|.:.|::                .:|..||..::.::..
Zfish  1170 YSVNRFIDDLPEVSTSTLPP-----DLDEQLKK----------------TEQNNPVHLSSKSTNS 1213

  Fly  1221 PPLPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHTTFA 1285
            ...||..         ||        ::||..|..    :||.         ||......|..|:
Zfish  1214 LASPLSS---------PM--------KQKPPISPK----KPNL---------SLIIPPIMHLPFS 1248

  Fly  1286 PGPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRPIV 1350
            .|..:::...|..:.||           ...:|| |||.:..|..:.. .|.......:::...|
Zfish  1249 NGLKLQQVHEAQETLES-----------EQVNGA-SSTNTVNLQAIPL-DLEVEEESDSDLSTPV 1300

  Fly  1351 AKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYETIAAPVANLMMPSPSGKSNSSTGSTATSS 1415
            .||.|| ..||::   ::|:|| .||.....|.....::.....|.    ..||.|..||:::|.
Zfish  1301 VKSRLS-FCSELS---SSSFQD-LQLSDYILNEHDLGLSDKDFGLC----DDKSTSDDGSSSSSG 1356

  Fly  1416 SSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTLQNRRSQPRPQPAGNV 1480
            |.|......||....|.:|.|......::....:...||.                 ||:..   
Zfish  1357 SISFKEDEHEENGAVFDSITESTSDINASGEAVEGMVTPV-----------------RPRTT--- 1401

  Fly  1481 TCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFLTSTPTRSGEGERDSEN 1545
               :||:|.    ..|..|.|.....:..|..| |:.|..|         .|||.|         
Zfish  1402 ---EDLFAA----IHRSKRKVLGRGDSEDERCR-NLLPSPP---------VTPTGS--------- 1440

  Fly  1546 TQLPPMKQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKP 1610
                   .||      .|.:.::....:.:|.|:...||.|||.|.:: |....::||.|:||  
Zfish  1441 -------CPS------LPRQTSSIQRNLRRSTTSNDSFKALLLKKGSR-SESSFRMSAAEILK-- 1489

  Fly  1611 AQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFANRRMLRQGQFGSPSKTFAPK 1675
                .|.|..:.:.....:|...|.||                 :|||...:.          .:
Zfish  1490 ----CTDPRFQRANSENALADGLSSPT-----------------SNRRAHEEW----------AR 1523

  Fly  1676 MRGPVNMVAAAAAPPRTDIMSTTIPEANSEEDHSN---TSGGSRASSEAGETVPSSFDLKRNFFL 1737
            |.|.:.........|:.. .|.|.|.|.|...:|.   ||....|..|....|..|.|.     .
Zfish  1524 MEGALPRFTTGQTIPKYG-RSRTPPSAASSRYNSRSRITSRPMTAICERDGEVAESTDC-----Y 1582

  Fly  1738 QTEENNFMRGELKPSFARSNGAAGGGST 1765
            .:.||:|:.     :.:.|:.....|||
Zfish  1583 ISSENHFVL-----ALSSSSMVCAQGST 1605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gukhNP_732393.1 NHS <818..>846 CDD:291922 15/76 (20%)
nhsl1aXP_005158876.2 NHS 355..911 CDD:317649 102/593 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 134 1.000 Inparanoid score I4565
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.050

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