Protein Alignment gukh and nhsb

DIOPT Version :9

• Sequence 1: NP_732393.1
• Gene: gukh / 53563
• FlyBaseID: FBgn0026239
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: XP_021335532.1
• Gene: nhsb / 559636
• ZFINID: ZDB-GENE-090617-2
• Length: 1630
• Species: Danio rerio
• Alignment Length: 1880
• Identity: 385/1880 - (20%)
• Similarity: 597/1880 - (31%)
• Gaps: 600/1880 - (31%)

  Fly   141 SISNITLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCAYDPK------ 199
            ||:|:.||..||||:.|...|..:|.:|:.::.:..:|...:|.||..:::...|.|||
Zfish    31 SITNVALSRTLRQLSDLSKHACSLFQELENEIVSTNQRVWALQNKIGKIQQTASALDPKMEAVRF 95

  Fly   200 -TVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKELPVATGATATALASL 263
             ::::..|:|...::...|::.....|..||...|||..:.:|:..|...|............|.
Zfish    96 RSISIAVSNLDIESKLTSHYQAPWHQQHNLFHTCTRPACLEELHRHAKLNLRALHRDQQQRQRST 160

  Fly   264 AHSQSLIP-SRSISFNGEVLSSDHEV--LQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIR 325
            :..:|.:. |.|::.......|.|::  .:..|.....:..:..||.....||.|...|:|.:
Zfish   161 SRERSRVTISISVAPPMPTFPSTHKLRRREQRGRHSRMERSVRESDVQTIQRKERPAKDSEFK-- 223

  Fly   326 LPAAIEDLRKWTSSEALGDVTVTPDCMHHV------DTSVSTSLAIGENGILTPALSPSVLSADA 384
             |.    |||:..|.:...|    .|.:.:      .|:..|.   ||..::
Zfish   224 -PV----LRKYQRSRSPSPV----QCCYFIPWIRKAGTNTETD---GELQVM------------- 263

  Fly   385 VDALYAQNLSQAADSSRHNHHTQALIPN---------DINKDVPLNHRLPSPEEQTKQIALKYPA 440
                              :|..:..:||         :.:|.:|    ||:|||:.|..:....:
Zfish   264 ------------------SHRPKCPVPNAPTTLDKQTNWSKALP----LPTPEERIKNDSQVISS 306

  Fly   441 EVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQTEGNNLDDNVQTVSRRSRSR 505
            .:|.:|.||..|.|..:||.|.                                |.:.|...|.|
Zfish   307 CIIPINVSGVGFDREASARCSL--------------------------------VHSQSVLQRRR 339

  Fly   506 KVRGKRRNTIAGIDQKEIQDAANGNGESKNASNATSPVAPAQQAETTSSDAKKSKKFGR--SKSS 568
            |:|  ||.||.||.::..||          ..:..|||| .::.....::..||.::..  |.|.
Zfish   340 KLR--RRKTITGIPKRVQQD----------MDSDESPVA-RERTVIIHANPHKSHEWHEELSLSG 391

  Fly   569 DIL-KKESAALPYDKGKSTLTRLNSLKQWGRN-RFKFMHRTGELGDQLDTSGCSSQNSSAEKA-- 629
            .:| .|:|.....|...:..:|.....|.|:. .....|.||.:....|.|......:||.:.
Zfish   392 RVLHTKDSGCQTDDFLITAPSRRRIRAQRGQGIPASLSHSTGNITSLPDRSDTVYAAASATRVRS 456

  Fly   630 ------------DSHHGSPAGDNSKRDIDDECVVHHLVAQKSE---------------------- 660
                        :....|...|:...|.|||.....|...::|
Zfish   457 RSLPREGGRLLDEDQDDSDDDDDEDDDEDDEEEDEELSPYEAEDFLPGPGQRIPKDEEESTDDQA 521

  Fly   661 ---------SRFSHERKPSYSSSEK------------SISVSSSGQLRGRLQLSSGPMAAAHVKM 704
                     .|..|...|.::..|:            |..:|||.      ...|.|:.:|..
Zfish   522 MPELQFGSLKRMQHSESPDHTWIERGRSRLPRKVDMGSCEISSSS------DTFSSPIHSAST-- 578

  Fly   705 RETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSESGRASIGSEITMQPKSSA---------SS 760
              |..|..|        ...:|...|||||||.|| |...|..|| |:.|.:|.         |.
Zfish   579 --TGVLGSQ--------IDHKEDHQSSSGNWSGSS-STCPSQTSE-TLPPAASPPLTGSSHCDSE 631

  Fly   761 TSLNVSSF----------------QPGGAGSGPPSSMLSRRRFLNTSASSSVTSEGTATP----- 804
            .|||..|.                :|.|.|        .|.....:||:..:...|.:|.
Zfish   632 LSLNTGSHVIDDNTGFIIDPYHIDKPQGQG--------QRSNSFTSSATDQMDDAGVSTASDGEW 688

  Fly   805 -------------------ELQAEAG-AYPGHLDDETSSAYS-------------CDTEGYYTSF 836
                               ..:.|:| :.|.:...||..::|             .||||:|:|.
Zfish   689 NCAQDQQDQSCTQDFSPKRSREDESGVSCPSYSSGETYESFSDQASARKSEMHYIVDTEGFYSSM 753

  Fly   837 HMDSGLRTLKEE------EPSVMPGTPLQTSLHTSSYSFGSQSNQTVLNAESEYELFGRGSTSTT 895
            |.||||:..:..      :|...|...:...:  :.|            .:.||.         .
Zfish   754 HFDSGLKGSRSYYNYAAIDPDCGPSGNIAPGM--TEY------------PQPEYR---------A 795

  Fly   896 TSSAGTVCTALMSGAASGPDVPERSSSLGKHSG------QSRSQST-----SASSSTLERSYSSS 949
            |.:.|..|.:|....|. |..|:|||||.:.|.      |:..:.|     ..||..::.....:
Zfish   796 TRTLGRPCLSLRKPKAK-PPPPKRSSSLKETSSDVNVPEQNEPKITCELPLPLSSREMKLQLDLA 859

  Fly   950 TIGSTLERTGTIK------RNVK-----MSPTKAGGEVTEKD---------------DQQDQDQQ 988
            .....||..|...      .||:     .||..:....:.||               |.:..|..
Zfish   860 DSAGHLETAGLESLGAWGVENVRDMLDCSSPFSSSDTHSFKDEGAVQADYADLWLHNDLKSNDPY 924

  Fly   989 QQLEFSESSDLEGVERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQTNDPNRTLTSLTIDVEH 1053
            :.|  |.||...|...||                ||.:|..|   |..|..|....:|.|:....
Zfish   925 RSL--SNSSSATGTTVIE----------------CIKSPERS---ETHTCQPRSRPSSPTLPPPE 968

  Fly  1054 GEQDEDEAEQKTPTNSKDHNLNELKQTPTKALSGMFEKLRVKLVPGKSSPAKNQMQPK-PANSSA 1117
            .|......|:.....|.....:...:|||.:....|       .||..||...:.:|| |...|:
Zfish   969 SEFKLASPEKLAGLASPSSGYSSQSETPTSSFPSAF-------FPGPLSPTSGKRKPKVPERKSS 1026

  Fly  1118 VNDDELYDLAGEYVTIADISNNNNNNKNIGRRNTGMGIYYSNDIVSKRVEPSTSAVSEYVSLNEL 1182
                 |..|..:.:::.|..                        :|.|.|....|:.
Zfish  1027 -----LCSLQQQQLSVRDPG------------------------ISCRRETDFYAIP-------- 1054

  Fly  1183 PQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATSQPPPLPLGGRTQGVGDGVPMYAEIGELSE 1247
            |.||...|:.|:..|.........|.                                     .:
Zfish  1055 PSHLDLSALHSKHFPHRNQMHILHQN-------------------------------------KQ 1082

  Fly  1248 EKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHTTFAPGPYVKETESALHSAESAAAAIASSQD 1312
            :..:|:||....|..|                     |.....:...:|...|.|||.|.|:::
Zfish  1083 KAAIAAAAAAEARSAA---------------------AAAAEARSAAAAAAEARSAATAAAAAE- 1125

  Fly  1313 PSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRPIVAKSPLSRNVSEMATYQATSYQDQKQLL 1377
              |.:.|.:|||.:    .|:...||.:..:.   |.|.:|...|::...:.......||...|:
Zfish  1126 --ACTAATASTKES----ATNTAPISAHLAIT---PTVLRSVQLRSICRPSDGNQGLDQDSSNLI 1181

  Fly  1378 A------------------NRTNPFYETIAAPVA--------NLMMPSPSGKSNSSTGSTATSSS 1416
            .                  ||..|.|:..||.|.        |::.|....:.........|..:
Zfish  1182 TRPKCPTIITDAPSSSNRHNRKPPAYKPPAAQVCDSQIPLVENIVFPQEEVRVRQERFGPGTYWA 1246

  Fly  1417 SSA------SGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWTL------QNRR 1469
            .:|      .....|...:|.|..::|.|.:              :|...:..||      |:..
Zfish  1247 MTAFRTPVDPNCEKEVSLKRSSQCFQQEQDS--------------RRCLDVQKTLSPERLKQDLN 1297

  Fly  1470 SQPRPQPAGNVTCRDDLYATP----IRRA--------DRLPRPVAAAAATAAEGNRSNISPIVPR 1522
            ...||.|:....|.......|    |:|:        |::|      .:|....:...||.:  :
Zfish  1298 QLSRPDPSTQSMCLASTMPPPAYSEIQRSNFVLCNSPDKVP------VSTQEASHSYTISDV--Q 1354

  Fly  1523 NRSGAFLTS-TPTRSGEGE-RDSENT---------QLPPMKQPSRNWTDD---------APERLN 1567
            .|...:.|| ..|||...: |:.|:|         ...|....|...|||         :|.:|.
Zfish  1355 GREEDYETSGVATRSASQDIREEESTPDTEDYFSKDSTPSDNSSSPLTDDSRLDDDVFPSPNKLR 1419

  Fly  1568 TCAD---RIGQSKTTLMDFKKLLLAK-----SAKASPVQRKVSAVELLKKPAQATATPPVVKPSG 1624
            |..|   .|.:||      :|:|..|     |.|..||...|:..  :..|......|....||.
Zfish  1420 TTEDLFAMIHRSK------RKVLGRKDSGEVSGKGRPVVPPVTTP--VSNPTVCPVIPAPPVPSN 1476

  Fly  1625 PGQKVA-----SAGSKPTINTSLKLLDLSGSPKTFANRRMLRQGQFGSPSKTFAPKMRGPVNMVA 1684
            ..|:.:     ||....|.:...|||.|....:|.::.||.......||   ..||.:..: ::.
Zfish  1477 NSQRASGPIYRSAKKSSTSSEEFKLLLLKKGSRTDSSYRMSATEILKSP---ITPKTQAEL-LLE 1537

  Fly  1685 AAAAP-----PRTDIMS------TTIPEANSEEDHSNTSGGSRASSEAGETVPSSFDLKR 1733
            |...|     |:.|..|      :..|:||||.....|...|.||.:....:|.:.:..|
Zfish  1538 AMRQPEEIPLPQLDSTSSGDPLPSPFPKANSEGFSPKTLTMSAASRQGRSRIPPAANSSR 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	14/40 (35%)
nhsb	XP_021335532.1	NHS	392..1047	CDD:317649	152/763 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4565
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.050