DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gukh and zgc:109889

DIOPT Version :9

Sequence 1:	NP_732393.1	Gene:	gukh / 53563	FlyBaseID:	FBgn0026239	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_001314967.1	Gene:	zgc:109889 / 553542	ZFINID:	ZDB-GENE-050522-547	Length:	540	Species:	Danio rerio

Alignment Length:	495	Identity:	100/495 - (20%)
Similarity:	164/495 - (33%)	Gaps:	130/495 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1125 DLAGEYVTIADI-------SNNNNNNKNIGRR---NTGMGIYYSND------IVSKRVEPSTSAV 1173
            |...|.|::.||       |:...:.:.:.|.   |..:.:|:..|      |:|...:....|:
Zfish    84 DSTVEEVSLQDINMRKAFKSSTIQDQQVVSRNSIPNPVLELYHRGDKPPPLNILSPYRDDKKDAL 148

  Fly  1174 SEYV---------------SLNELPQHLRRHAVS-SRSAPAAESESCAQQQLPVEPAAATSQPPP 1222
            ..|.               :..:..:..||...| |....:.:::|.::|.|...|..::.|...
Zfish   149 KFYTDPSYFFILWREKMLQATEDKRKEKRRQKTSGSGQTHSDQTKSHSRQALLRSPLLSSEQQKQ 213

  Fly  1223 LPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRR-----------LRPNA------------E 1264
            :....|                  |.|.:..|.|||           .||:|            |
Zfish   214 VEDPSR------------------EVKKVRKARNRRQEWNVMAYDKEFRPDARFTPSPYHGMSSE 260

  Fly  1265 GKLVYDSDSLKRRKGAHTTFAPG-PYVKETESALHSAESAA------AAIASSQDPSAASGAISS 1322
            |.|..|:.|:....|.|:  .|| |.....:.|:.||.|||      .|.:..|..|...|...:
Zfish   261 GSLSPDNRSVASDMGEHS--YPGSPSHPAQQMAVSSAYSAADGKEHLMAPSHVQTQSLDRGYRPA 323

  Fly  1323 TKSAKLLLLTSGGLISGNRKVANVRPIVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYET 1387
            ..||    ...|....|..:.::.:||.  .|.......:.|...:..|.|.:       .::..
Zfish   324 PSSA----APPGRQTIGRVQTSHGQPIT--DPALNGPRPLQTKDYSGQQSQHR-------EYFVP 375

  Fly  1388 IAAPVANLMMPSPSGKSNSSTGSTATSSSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATA 1452
            .|.|....::||.....:|.||.::..:|:..|          .|..|.|..|.|:.    .|:.
Zfish   376 PAPPPPPPLIPSAQTAFDSPTGPSSAPASAMPS----------LSQTYSQSPPTPAL----PASY 426

  Fly  1453 TPFQRSAPIYWTLQNRRSQPRPQPAGNVTCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNIS 1517
            ||.....|        .:.|.|.|.|..|             ...|.|:.||:..|....|....
Zfish   427 TPSPTHPP--------PAAPPPPPPGPPT-------------HPHPHPMPAASVEAPVVPRKGQV 470

  Fly  1518 PIVPRNRSGAFLTSTPTRSGEGERDSENTQLPPMKQPSRN 1557
            |::|.:.:.:.|.:...|..:..:..|..:....|:|..|
Zfish   471 PLIPMSDARSDLLAAIRRGIQLRKVQEQREQEAKKEPVGN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922
zgc:109889	NP_001314967.1	WH2	478..495	CDD:128542	2/16 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12902
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010