DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gukh and NHS

DIOPT Version :9

Sequence 1:NP_732393.1 Gene:gukh / 53563 FlyBaseID:FBgn0026239 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001278796.1 Gene:NHS / 4810 HGNCID:7820 Length:1651 Species:Homo sapiens


Alignment Length:2054 Identity:401/2054 - (19%)
Similarity:656/2054 - (31%) Gaps:756/2054 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPFVQRVVQPVNVAQ--------ATAASLGHAS--------GRFHCTPGKCRNNNCINKQSPDVE 49
            |||.:|:|:|..:.:        |..||.|.|.        ||               :...:||
Human     1 MPFAKRIVEPQWLCRQRRPAPGPAVDASGGSAEPPPPLQPPGR---------------RDLDEVE 50

  Fly    50 VPNGHGSPTSLTRVLVHQAPEDQPVPPAPAPMKKLKHHVEFLSTSPTRHQSQSLPNSRHPS---Q 111
            .|    .|....|.:...:....|.||.|||..:         |.|. |...|:......:   :
Human    51 AP----GPEEPARAVPAPSGLPPPPPPLPAPADQ---------TQPP-HGEASVAGEESTAGIPE 101

  Fly   112 QRPALGRIASAPQSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAVG 176
            ..||.|..:||     |.::.|:...:..::||..|:..||||:.:...|..:|.:|:.|:|...
Human   102 AAPAAGEASSA-----AAAAAVLLMLDLCAVSNAALARVLRQLSDVARHACSLFQELESDIQLTH 161

  Fly   177 ERAGRVQRKIAAVERRVCAYDPKTVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQL 241
            .|...:|.|:..|:|.:...|||...||.|:|...::...::......|:.:|...|||..|.:|
Human   162 RRVWALQGKLGGVQRVLSTLDPKQEAVPVSNLDIESKLSVYYRAPWHQQRNIFLPATRPPCVEEL 226

  Fly   242 YTEAGKEL--------------------PVATGATATALASLAHSQSLIPSRSISFNGEVLSSDH 286
            :..|.:.|                    |::..|........||||     |...|      .|.
Human   227 HRHARQSLQALRREHRSRSDRREQRAAAPLSIAAPPLPAYPPAHSQ-----RRREF------KDR 280

  Fly   287 EVLQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDC 351
            ..|..|.:                              |.|:..|                   |
Human   281 HFLTFNST------------------------------RSPSPTE-------------------C 296

  Fly   352 MHHVDTSVSTSLAIGENGILTPALSPSVLSADA-VDALYAQNLSQAADSSRHNHHTQALIPNDIN 415
            .|                 :||....|....|. .|.:    |.|...:..||      ||:.::
Human   297 CH-----------------MTPWSRKSHPPEDEDTDVM----LGQRPKNPIHN------IPSTLD 334

  Fly   416 KDVPLNHR--LPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSST 478
            |....:..  ||:|||:.||.|....:.:|.:|.:|..|.|..:.|.|.                
Human   335 KQTNWSKALPLPTPEEKMKQDAQVISSCIIPINVTGVGFDREASIRCSL---------------- 383

  Fly   479 SPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGID---QKEIQDAANGNGESKNA---- 536
                            |.:.|...|.||:|  ||.||:||.   |:||....:.....:|.    
Human   384 ----------------VHSQSVLQRRRKLR--RRKTISGIPRRVQQEIDSDESPVARERNVIVHT 430

  Fly   537 ----SNATSPVAPAQQAETTSSD---AKKSKKFGRSKSSDILKKESAALPY---------DKGKS 585
                ||..:.::..:.:|..:.|   |..|::..|::....:   :|:|.:         |||.:
Human   431 NPDPSNTVNRISGTRDSECQTEDILIAAPSRRRIRAQRGQSI---AASLSHSAGNISALADKGDT 492

  Fly   586 TLTRLNSLKQWGRNRFKFMHRTGELGDQLDTSGCSSQNSSAEKADSHHG--------------SP 636
            ..|...|    .|.|.:.:.|.|..|...:.. ..::.|:.|:.:|..|              ||
Human   493 MFTPAVS----SRTRSRSLPREGNRGGDAEPK-VGAKPSAYEEGESFVGDHERTPNDFSEAPSSP 552

  Fly   637 AGDNSKRDIDDECVVH-----HLVAQKSESRFSHERKPSYSSSEKSISVSSSGQLRG---RLQLS 693
            :..:.:..:...|..|     |.::::..||.|.     .::...|..:||:....|   ....:
Human   553 SAQDHQPTLGLACSQHLHSPQHKLSERGRSRLSR-----MAADSGSCDISSNSDTFGSPIHCIST 612

  Fly   694 SGPMAAAHVKMRETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSE------------------ 740
            :|.:.::|:                    .:::...|||||||.||.                  
Human   613 AGVLLSSHM--------------------DQKDDHQSSSGNWSGSSSTCPSQTSETIPPAASPPL 657

  Fly   741 SGRASIGSEITM------------------------------------------QPKSSASSTS- 762
            :|.:...||:::                                          .|.:|.:|.| 
Human   658 TGSSHCDSELSLNTAPHANEDASVFVTEQYNDHLDKVRGHRANSFTSTVADLLDDPNNSNTSDSE 722

  Fly   763 -------------LNVSSFQPGGAGSGPPS--SMLSRRRFLNTSASSSVTSEGTATPELQAEAGA 812
                         .:.|..:|.....|.||  ||.:...||..|.|...                
Human   723 WNYLHHHHDASCRQDFSPERPKADSLGCPSFTSMATYDSFLEKSPSDKA---------------- 771

  Fly   813 YPGHLDDETSSAYSCDTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTSLHTSSY-SFGSQSNQT 876
                   :|||.:|.||||||||.|.|.||:..|.               :...| :.|.::.|.
Human   772 -------DTSSHFSVDTEGYYTSMHFDCGLKGNKS---------------YVCHYAALGPENGQG 814

  Fly   877 VLNAES----------EYELFGRGSTSTTTSSAGTVCTALMSGAASGPDVPERSSSLGKHSGQS- 930
            |..:..          :::..||.|.|.....|             .|..|:|||||.|..|.: 
Human   815 VGASPGLPDCAWQDYLDHKRQGRPSISFRKPKA-------------KPTPPKRSSSLRKSDGNAD 866

  Fly   931 ---RSQSTSASSSTLERSYSSSTIGSTLERTGTIKRNVKMSPTKAGGEVTEKDDQQDQDQQQQLE 992
               :.:...:|...|..|.....:......|.:...|..: |||.......:.:|..::.|    
Human   867 ISEKKEPKISSGQHLPHSSREMKLPLDFANTPSRMENANL-PTKQEPSWINQSEQGIKEPQ---- 926

  Fly   993 FSESSDLEGVERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQTNDPNRTL------TSLTI-- 1049
             .::||      |...|.:.| .|.....:.::       ::.:||||.|:|      |..|:  
Human   927 -LDASD------IPPFKDEVA-ESTHYADLWLL-------NDLKTNDPYRSLSNSSTATGTTVIE 976

  Fly  1050 ---DVEHGEQDEDEAEQKTPTNSKDHNLNELK---------------------QTPTKALSGMFE 1090
               ..|..|....::|.:..|.|.....||.|                     :|||.:....| 
Human   977 CIKSPESSESQTSQSESRATTPSLPSVDNEFKLASPEKLAGLASPSSGYSSQSETPTSSFPTAF- 1040

  Fly  1091 KLRVKLVPGKSSPAKNQMQPK-PANSSAVNDDELYDLAGEYVTIADISNNNNNNKNIGRRNTGMG 1154
                  ..|..||..::.:|| |...|::....|.|..                           
Human  1041 ------FSGPLSPGGSKRKPKVPERKSSLQQPSLKDGT--------------------------- 1072

  Fly  1155 IYYSNDIVSKRVEPSTSAVSEYVSLNELPQHLRRHA--VSSRSAPAAESESCAQQQLPVEPAAAT 1217
            |..|.|:....:.|:...:|...::...|.| .||.  |.:.:......|:            ..
Human  1073 ISLSKDLELPIIPPTHLDLSALHNVLNKPFH-HRHPLHVFTHNKQNTVGET------------LR 1124

  Fly  1218 SQPPPLPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHT 1282
            |.|||                     .|:....:..:.|.|        .:..|:.:|:::..:|
Human  1125 SNPPP---------------------SLAITPTILKSVNLR--------SINKSEEVKQKEENNT 1160

  Fly  1283 TFAPGPYVKETESALHSAESAAAAIASSQDPSAASGAIS---STKSAKLLLLTSGGLISGNRKVA 1344
            ..   ||::|      |..:.||...|...|..|:.::|   ||:...|..|.|..:..|..|: 
Human  1161 DL---PYLEE------STLTTAALSPSKIRPHTANKSVSRQYSTEDTILSFLDSSAVEMGPDKL- 1215

  Fly  1345 NVRPIVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYETIAAPVANLM------------- 1396
                         ::.:.:|:.          :.||.:|  |||.:..::|:             
Human  1216 -------------HLEKNSTFD----------VKNRCDP--ETITSAGSSLLDSNVTKDQVRTET 1255

  Fly  1397 MPSPSGKSNSSTGSTATSSSSSASGQSGEEGYQRFS-------------------NIYEQVQPAP 1442
            .|.|   .|:.|.:.|..:          ||:||.|                   ...||||.||
Human  1256 EPIP---ENTPTKNCAFPT----------EGFQRVSAARPNDLDGKIIQYGPGPDETLEQVQKAP 1307

  Fly  1443 S------TQPQEDATATPFQRSAPIYWT-LQNR------RSQPRPQPAGNVTCRDDL-----YAT 1489
            |      .|| |.......|..:|...| :.|:      .|:...:..|.::...::     :..
Human  1308 SAGLEEVAQP-ESVDVITSQSDSPTRATDVSNQFKHQFVMSRHHDKVPGTISYESEITSVNSFPE 1371

  Fly  1490 PIRRADRLPRPVAAAAA---TAAEGNRSN----------------ISPIVPRNRS---GAFLTST 1532
            ...:.:.:...::|.:|   :.||..:.|                |||:...:::   |.|::..
Human  1372 KCSKQENIASGISAKSASDNSKAEETQGNVDEASLKESSPSDDSIISPLSEDSQAEAEGVFVSPN 1436

  Fly  1533 PTRSGE--------------GERD---------------SENTQLPPMKQPSRNWTDDAPERLNT 1568
            ..|:.|              |.:|               |.::....:..||.|.|....:|...
Human  1437 KPRTTEDLFAVIHRSKRKVLGRKDSGDMSVRSKSRAPLSSSSSSASSITSPSSNVTTPNSQRSPG 1501

  Fly  1569 CADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKPAQATATPPVVKPSGPGQKVASA- 1632
            ...|..:...|..:..||||.|....|....::||.|:||.|         :.|..||:..|.: 
Human  1502 LIYRNAKKSNTSNEEFKLLLLKKGSRSDSSYRMSATEILKSP---------ILPKPPGELTAESP 1557

  Fly  1633 --------GSK------------PTINTSLKLLDLSGSPKTFANRRMLRQGQFGSPSKTFAPKMR 1677
                    ||:            |.:|..      ..|.|:||.....|.|:..:|         
Human  1558 QSTDDAHQGSQGAEALSPLSPCSPRVNAE------GFSSKSFATSASARVGRSRAP--------- 1607

  Fly  1678 GPVNMVAAAAAPPRTDI---MSTTIPEANSEEDHSNTSG 1713
                   .||:..|..:   :..|..:|.||.:..|:.|
Human  1608 -------PAASSSRYSVRCRLYNTPMQAISEGETENSDG 1639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gukhNP_732393.1 NHS <818..>846 CDD:291922 16/27 (59%)
NHSNP_001278796.1 WAVE homology domain (WHD) 1..262 70/294 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..104 28/131 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..274 6/43 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..314 9/91 (10%)
NHS 440..1060 CDD:291922 139/730 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..598 20/113 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 620..669 13/68 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 835..888 17/65 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..1004 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1071 12/60 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1383..1436 10/52 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1454..1509 9/54 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1526..1651 31/145 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 118 1.000 Inparanoid score I4798
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto91687
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5053
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
44.080

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