Protein Alignment gukh and nhsl1b

DIOPT Version :9

• Sequence 1: NP_732393.1
• Gene: gukh / 53563
• FlyBaseID: FBgn0026239
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: XP_005160821.1
• Gene: nhsl1b / 447799
• ZFINID: ZDB-GENE-040910-1
• Length: 1606
• Species: Danio rerio
• Alignment Length: 1877
• Identity: 380/1877 - (20%)
• Similarity: 611/1877 - (32%)
• Gaps: 632/1877 - (33%)

  Fly   139 FDSISNI---TLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCAYDPKT 200
            |.|:..:   |.::.|.||:.|...|||||..::.....:..|..|:|.::..::..|...|||:
Zfish    40 FSSLEEVCCHTFTSILHQLSDLSRHASDIFLGIETQAGLISHRTSRIQARLERIQHTVQTLDPKS 104

  Fly   201 VTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKELPVATGATATALASLAH 265
            |.:|.|:|....:...|:......|:.:|...:||..|..|:.:|...|..|. .....|.....
Zfish   105 VKIPVSNLDEEKKWTVHYTAPWHQQENVFLPGSRPACVEDLHRQAKVNLKTAL-RECDKLRKDGF 168

  Fly   266 SQSLIPSRSISFNGEVLSSDHEVLQLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAI 330
            ..|...|:..:|:|. .||.||...|.|  |..|.....|. |...:.     ..::..:.||.:
Zfish   169 RSSQYYSQGPTFSGS-SSSQHEDEDLEG--DDADKKSTASS-GEEEKD-----SCQMRAQSPAQV 224

  Fly   331 EDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGILTPALSPSVLSADAVDALYAQNLSQ 395
            |.:                    .||..:|:|.|             ||
Zfish   225 EGV--------------------EVDGQMSSSKA-------------SV---------------- 240

  Fly   396 AADSSRHNHHTQALIPNDINKDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARK 460
                                        ||:|||:.:|.|.....:::.:|.:|:.|.|..:.|:
Zfish   241 ----------------------------LPTPEEKMRQQAQAVLTDIVPINVTGETFDRQASIRR 277

  Fly   461 STSGGYAGGATAGSSSSTSPENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGI-DQKEIQ 524
            |..                              |..|:.|  |.:||  |||.||:|: |..:.:
Zfish   278 SLI------------------------------NTDTLVR--RPKKV--KRRKTISGVPDSVQQE 308

  Fly   525 DAANGNGESKNASNATSPVAPAQQAETTSSDAKKSKKFGRSKSSDILKKESAALPYDKGKST--- 586
            .||.|.|   ......|...|.|.:           ..||..:.:...::|  :..|.|..|
Zfish   309 LAAKGRG---GELRPQSMFIPGQYS-----------TLGRVMNGNSTLRQS--VTKDSGCQTEAV 357

  Fly   587 ------LTRLNSLKQWGRNRFKFMHRTGELGDQLDTSGCSSQN-SSAEKADSHHGS------PAG 638
                  :.|:.:.|..|            :..|:.....|:.| ||.....|..||      ..|
Zfish   358 KIVPPSVRRIRAQKGQG------------IAAQMAGISTSATNISSVSDGSSTGGSIVAMAPQFG 410

  Fly   639 DNSKRDIDDECVVHHLVAQKSESRFSHERKPSYSSS--EKSISVSSSGQLRGRLQLSSGPMAAAH 701
            ::.:|       .|.|   ...:|.|...:|.|||:  .|..|.:.:.:..|:||:.:   .|.|
Zfish   411 NDIQR-------FHSL---PRGARVSLNAEPIYSSTPFRKEDSCAKAPKQIGKLQVDN---TAVH 462

  Fly   702 VKMRETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSESGRASIGS-----EITMQPKSSASST 761
              ||....:..|.|       .|.::...|...|  .|.||.|.:.|     ..::.|.::.|.:
Zfish   463 --MRNAPRVCTQAR-------PKSQEVRGSQREW--GSVSGPACVVSPHAAYSTSLIPNATLSCS 516

  Fly   762 SLNVSSFQPGGAGSGP----------PSSMLSRRRFLNTSASSSVTSEGTATPELQ-----AEAG 811
            :...:.......|..|          |.||:|   .:|:.::||| ..|:.||:..     :|.|
Zfish   517 AEVFALHSKSSPGQSPLSGSPYTKARPLSMVS---VVNSGSTSSV-GTGSHTPDAGMKDTCSETG 577

  Fly   812 ------------------------------AYP------------GHL---------DDETSSAY 825
                                          |.|            .||         ..::||.|
Zfish   578 QSDSSLHSHSTIAAGTLSSDEQWIYDTPDNALPRRTMTSSCSTPINHLYSSLERSSKGTDSSSLY 642

  Fly   826 SCDTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTSLHTSSYSFGSQSNQTVLNAESEYELFGRG 890
            |.|.:|||||.|:|||||:..                |.|.:..|......   ..|.||..|..
Zfish   643 SMDNDGYYTSMHLDSGLRSRS----------------HGSGHGHGIGGRAV---RHSMYECLGEQ 688

  Fly   891 STSTTTSSAGTVCTALMSGAASGPDV-PERSSSLGKHSGQSRSQSTSASSSTLER-SYSSSTIGS 953
            ....:..|..::..::.......|.: |.|:.||.:..|::.|.|.:...|.:.. |..:.::.:
Zfish   689 EDRNSLCSDHSLSRSISLRKPKKPPLPPARTDSLRRKPGKNSSPSANIGQSNIRNGSLLNESLIA 753

  Fly   954 TLERT---GTIKRNVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLEGVERIERIKQKTALT 1015
            ||:::   |...:....||:.:  ..::.:|......:.|...|.||  .||         :|..
Zfish   754 TLQQSLQNGLKGKGSSTSPSHS--PCSDYEDPWMLRPRSQSSISASS--SGV---------SATG 805

  Fly  1016 SKRIPSMCIITPTTSDDD--------------EHQTNDPNRTLTSLTIDVEHGEQDEDEAEQKTP 1066
            ...:.|:|.:||:.||..              |:.....::|.:..|.....|:..| .|..:.|
Zfish   806 MAHVYSICPVTPSHSDTSSLRSDYADSWGYYMEYPRPSGDQTQSPCTNSHSAGQVSE-MANGRGP 869

  Fly  1067 TNSKDHNLNELKQTPTKALSGMFEKLRVKLVPGKSSPAKNQMQPKPANSSAVNDDELYDLAGEYV 1131
            .|....||..:::.     |.|..|.|.    |.|||.:......|  ||..:.......||..|
Zfish   870 LNGNQANLPAVQEG-----SDMSAKPRT----GTSSPDRVHRLTSP--SSGYSSQSNTPTAGTPV 923

  Fly  1132 T--IADISNNNNNNKNIGRRNTGMGIYYSNDIVSKRVEPSTSAVSEYVSLNELPQHLRRHAVSSR 1194
            .  :..:|.:......:..|.:.:       :.|..:..|::::|...|            .|:|
Zfish   924 PSFMRCMSPSGKPKPRVPERKSSL-------LSSVSISSSSTSLSSNTS------------DSNR 969

  Fly  1195 S-------APAA------------------ESESCAQQQ--------LPVEPAAATSQ------- 1219
            |       .|||                  .|..|.:.|        ||..|....|.
Zfish   970 SNIPPPPPLPAAPVVLVPLNPPSFPPPLPPPSPVCTEDQKFPPPPPPLPTTPHQQASMNPLQNNS 1034

  Fly  1220 --------------------------------PPPLPLGGRTQG-----VGDGVPMYAEIGELS- 1246
                                            |||||....:|.     :....|..|.:.|:.
Zfish  1035 SPEFPPPPPPEVLTDPACSGFNSSFSPPPPPPPPPLPTYSPSQNQHLPHMTPQTPSSASLKEIKG 1099

  Fly  1247 -------EEKPLASAANR-----------------RLRP--NAEGKLVYDSDSLKRRKGAHTT-- 1283
                   |.:|:...:..                 :|||  ..|...|..:|..:..:..|.|
Zfish  1100 CLKPVNLEGRPVLPQSEEPNKVSMPLITPFALQSVQLRPAKRPENNEVSRTDRPQTPEKTHPTVP 1164

  Fly  1284 ----FAPGPYVKETE---SALHSAESAAAA-----IASSQDPSA--ASGAIS------------- 1321
                .:|...:..||   |..||.:....|     :.|:.||::  .:|.|.
Zfish  1165 QISCISPNVSLSSTEEKPSIQHSQDGLVEAQTDYSVKSNSDPTSFLTNGPIDLGEATDEVDGLKT 1229

  Fly  1322 --STKSAKLLLLTSGGLISGNRKVANVRPIVAKSP----LSRNVSEMATYQATSYQD-----QKQ 1375
              ||:..|.|          |.......|:::|.|    ...:|..:..:.:....|     :|:
Zfish  1230 FLSTQVEKSL----------NSTPKKKPPMISKKPKFSLTFSSVDHVRDFVSAEVLDPIPVLEKE 1284

  Fly  1376 LLANRTNPFYETIAAPVANLMMPSP-SGKS---NSSTGST---------------------ATSS 1415
            ......:.|  .|:.|...:...|| :|:|   :.|:|:|                     .|||
Zfish  1285 EETTEKSSF--DISVPPVEIRDISPTNGESQEFSQSSGTTILDVDKSTSEAEDEEERDDEDVTSS 1347

  Fly  1416 SSSASGQSGEEGYQRFSNIYE----QVQPAPSTQPQE-DATATPFQRSAPIYWTLQNRRSQPRPQ 1475
            :.|.|.:..|.|     :::|    .|..:||..... ....||               ::||
Zfish  1348 TGSFSSKDDENG-----DVFESSTLDVAQSPSINGDSCGDMVTP---------------TRPR-- 1390

  Fly  1476 PAGNVTCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNIS-PIVPRNRSGAFLTSTPTRSGEG 1539
                  ..:||:|.    ..|..|.|.....:..:.:|..:| |:.|..:|.:..:|.|.:||..
Zfish  1391 ------TTEDLFAA----IHRSKRKVLGRKESEEDRSRGPLSPPVTPTAQSPSLTSSLPRQSGSI 1445

  Fly  1540 ERDSENTQLPPMKQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAV 1604
            :|.                              :.:|.|:...||.|||.|.:: |....::||.
Zfish  1446 QRS------------------------------LRKSATSSDTFKALLLKKGSR-SESSFRMSAT 1479

  Fly  1605 ELLKKPAQATATPPVVKPSGPGQKVASAGSK--PTINTSLKLLDLSGSPKTFANRRMLRQGQFGS 1667
            |:|:      :|.|..      |:..|..|.  |...||.......|..|..|:......|.|.:
Zfish  1480 EMLR------STDPRF------QRTRSLDSSFDPASPTSESPCSSPGRSKRVADDWARNDGMFST 1532

  Fly  1668 PSKTFAPK---MRGPVNMVAAAAAPPRTDIMS---TTIPEANSE----ED---HSNT 1711
            ......||   .|.|.: .|::....|..|:|   |.|.|.:.|    ||   .|||
Zfish  1533 SPSLIGPKYGRSRTPPS-AASSKYNARCRILSSPMTVICERDGELTDCEDPVSPSNT 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	16/27 (59%)
nhsl1b	XP_005160821.1	NHS	343..944	CDD:291922	143/686 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4565
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.050