Protein Alignment gukh and Nhsl1

DIOPT Version :9

• Sequence 1: NP_732393.1
• Gene: gukh / 53563
• FlyBaseID: FBgn0026239
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: XP_017445312.1
• Gene: Nhsl1 / 308631
• RGDID: 1308124
• Length: 1667
• Species: Rattus norvegicus
• Alignment Length: 1973
• Identity: 402/1973 - (20%)
• Similarity: 650/1973 - (32%)
• Gaps: 665/1973 - (33%)

  Fly    95 PTRHQSQSLPNSRHPSQQRPALGRIASAPQSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVL 159
            |...:|......|.|.:   |.|.:|..|  |...|.:.||.|        ||...|.|||.|..
  Rat     2 PFHQRSVEPARLRRPEE---AAGALAGDP--PLFRSLEQVSSH--------TLVCLLAQLADLSR 53

  Fly   160 IASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCAYDPKTVTVPESDLLTFAQRKHHFETDKSF 224
            .|.|||.:|:....|:|.|...:.|::.|:.......|.:.|.:|.|:|...::...|:......
  Rat    54 CAGDIFGELEGQAAALGHRTAELHRRLDALHAAAARLDHRRVKIPVSNLDEESRWTVHYTAPWHQ 118

  Fly   225 QQELFTGETRPLSVRQLYTEAGKELPVATGATATALASLAHSQSLIPSRSISFNGEVLSSDHEVL 289
            |:.:|...|||..|..|                       |.|:.:..:|:....:.|..|.
  Rat   119 QENVFLPSTRPPCVEDL-----------------------HRQAKLNLKSVLRECDKLRRDG--- 157

  Fly   290 QLNGSTDTEDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDCMHH 354
                         |.|              ::...:.|.       :.:|.:.||.....|
  Rat   158 -------------CRS--------------SQYYSQGPT-------FAASSSPGDDYQEED---- 184

  Fly   355 VDTSVSTSLAIGEN----GILTPALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPNDIN 415
            .:|....||:..|.    ||..|. :|:  |.|..|.                 |||    .:..
  Rat   185 AETDRKYSLSSSEEERFIGIRRPK-TPT--SGDFSDL-----------------HTQ----TNWT 225

  Fly   416 KDVPLNHRLPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSP 480
            |.:|    ||:|||:|:|.|....|:|:.:|.:|::|.|..:.|:|.
  Rat   226 KSLP----LPTPEEKTRQQAQTVQADVVPINITGENFDRQASLRRSL------------------ 268

  Fly   481 ENAGQTEGNNLDDNVQTVSRRSRSRKVRGKRRNTIAGID---QKEIQDAANGNGESKNASNATSP 542
                          :.|.:...|.:||  |||.||:||.   |||:. :|.|..:..:..:..||
  Rat   269 --------------IYTDTLVRRPKKV--KRRKTISGIPDIIQKELA-SATGQEDDGSTHSLYSP 316

  Fly   543 ------------VAPAQQAETTSSD-------------------------AKKSKKFGRSKSSDI 570
                        .:..|..||..|.                         |:.|...|.|.:..:
  Rat   317 DHYSTLGRLDSYRSTGQCLETRDSGCQTEEVKVIPPSVRRIRAHKGLGIAAQMSHLSGSSGNMSV 381

  Fly   571 LKKESAALPYDKGKSTLTRLNSLKQWG--RNRFKFMHRTGELGDQLDTS------GCSSQNSSAE 627
            | .:||.:.:....:..|..:||.:.|  .:.:....|.|.||...||.      |.|||   ..
  Rat   382 L-SDSAGIVFPSRLNNDTGFHSLPRAGARASTYSLEARMGALGSAEDTDDTFPYRGGSSQ---GP 442

  Fly   628 KADSHHGS---------PAGDNSKRDIDDECVVHHLVAQKSESRFSHERKPS---YSSSEKSI-- 678
            :..:|.|.         |.....:......|||      ...:.:|....|:   .||||..:
  Rat   443 ENFAHLGGASSTGMLSRPKSQQLRLLESPACVV------SPHAAYSTSVIPNATLLSSSEVIVIH 501

  Fly   679 SVSSSGQLRGRLQ------------------------------------------LSSGPMAAAH 701
            :..|:|||..|:.                                          .|:.|.|.|.
  Rat   502 TAQSAGQLDSRVPGSSSYSKIKPRDHPTPRCSARDERQSPRHHWNEGHIIHSQALASAAPGATAL 566

  Fly   702 VKMRET-ATLNR---QRRNGLHAL-------AGKEEQPHSSSGNWSASSESGRASIGSEITMQPK 755
            :.:|:: .:||.   .|.||..|:       ......|....|. |..|.||....||..:.:.|
  Rat   567 LSLRDSEVSLNAPAINRENGSQAILYHCRSNLAFPAHPPDVDGK-SECSSSGDRGCGSSESWEYK 630

  Fly   756 SSASSTSLNVSSFQPGGAGSGPPSSMLSRRRFLNTSASSSVTSEGTATPELQAEAGAYPGHLDDE 820
            :|::.   ..|..:|                .|.|...|:.||..::....||.       |.::
  Rat   631 ASSNG---RASPLKP----------------HLATPGCSTPTSNMSSCSLDQAS-------LKED 669

  Fly   821 TSSAYSCDTEGYYTSFHMDSGLRTLKEEEPSVMPGTPLQTSLHTSSYSFGSQSNQTVLNAESEYE 885
            ..|.||.|.:|||.:...||     :.|..|.          :..|..||:..:.||       .
  Rat   670 ARSLYSEDHDGYYMTAQGDS-----RHEAGSA----------YGISDGFGNPRHSTV-------N 712

  Fly   886 LFGRGSTSTTTSSAGTVCTALMS------GAASGPDVPERSSSL-------GKHSGQSRSQSTSA 937
            :|. |....:.....|....::|      .|...|..|.|:.||       .:.:||..::|..|
  Rat   713 VFD-GRAQRSQGDQATQQDRILSRNISLKKAKKPPPPPSRTDSLRRIPKKNNQTNGQVLNESLIA 776

  Fly   938 SSSTLERSYSSSTIGSTLERTGTIKRNVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLEGV 1002
            |   |:.|...|..|   :.:|        ||:::  ..::.::......:.|...||.|.|
  Rat   777 S---LQHSLQLSLPG---QGSG--------SPSQS--PCSDCEEPWLPRSRSQSIVSEGSSL--- 822

  Fly  1003 ERIERIKQKTALTSKRIPSMCIITPTTSDDDEHQTN--DPNRTLTSLTIDVEHGEQDEDEAEQKT 1065
                     |:.|:..:.|:|.:||:.||....::.  ||    ....||....:.|........
  Rat   823 ---------TSTTTPNVYSLCGLTPSQSDTSSVKSEYADP----WGYYIDYTTLQGDPGNPTGGC 874

  Fly  1066 PTNSKD-------HNLNELKQTPTKALSGMFEKLRVKLVPGKSSPAKNQMQPKPANSSAVNDDEL 1123
            |.:|:.       .::.|..:.|...:.|...|      |..:||.|:|....|::..:...:..
  Rat   875 PASSEAATGNGPVRHIQEGSRAPVPQVPGCSVK------PKITSPEKSQRVTSPSSGYSSQSNTP 933

  Fly  1124 YDLAGEYVTIADISNNNNNNK---NIGRRNTGMGIYYSNDIVSKRVEPSTSAVSEYVS------L 1179
            ..|....|.:..:|..|...|   .:..|.:.:       |.|..:..|::::|...|      :
  Rat   934 TALTPVPVFLKSMSPANGKGKAKPKVPERKSSL-------ISSVSISSSSTSLSSNTSTEGSGTV 991

  Fly  1180 NELPQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATSQ-----PPPLPLGGRTQG-------V 1232
            .:|..     |::|..||       ....||..|:.:.:.     |||.||...::|       |
  Rat   992 KKLDS-----ALASALAP-------PPPPLPALPSPSLANKSPFLPPPPPLADCSEGSPLPPSPV 1044

  Fly  1233 GDGVPMYAEIGELSEEKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHTTFAP----------- 1286
            ....|..|.:       |..|..:|.|.|:.                  |.|:|
  Rat  1045 FPPPPPEALV-------PFCSPTDRCLSPSP------------------TAFSPPLPRCSPPLPA 1084

  Fly  1287 ------------------------GPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAK 1327
                                    .|::|.: |...|:..|....|:.::....|..:.:|::.:
  Rat  1085 PPPFLPPSEPPPAPPLDPKFMKENRPFIKNS-SQSESSREALRRPANKEEGCRPSMPLITTEALQ 1148

  Fly  1328 LLLLTSGGLISGNRKVANVRPIVAKSP----------------LSRN-VSEM-ATYQATSYQDQK 1374
            ::.|......||...|....| .|:.|                .||| ::|| :..||.|.....
  Rat  1149 MVQLRPVRKNSGAETVLFSEP-SAQEPRTPTAPQYHLKPSAFLKSRNSINEMESESQAASVTSSL 1212

  Fly  1375 QLLANRTN------------------------PFYETIAAPVAN---------------LMMPSP 1400
            .:.|...:                        |...|...|.::               |::|.|
  Rat  1213 PMPAKSQSQGDHDSAVERGGLQSCSDGAPGPGPSLRTALLPDSSPSRKPPPISKKPKLFLVVPPP 1277

  Fly  1401 S---GKSNSSTGSTATSSSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATA-----TPFQR 1457
            .   ....:..||.|.|...|.:|..||.|..      ::.:.:|::|....|||     |..:|
  Rat  1278 QRDFTAEPTENGSEAFSGVPSPTGAEGEAGQS------QEEKSSPASQAGSHATAPTSGSTVLER 1336

  Fly  1458 -------------SAPIYWTLQNRRSQ-PRPQPAG--------NV-TCRDDLYATPIRRADRLPR 1499
                         :||:   :|...|. |..:.||        || :|     |:|......||.
  Rat  1337 GTAGSLSPGVVEANAPM---VQPSTSPGPAQEEAGENRVDGERNVKSC-----ASPRGGEAGLPE 1393

  Fly  1500 P-VAAAAATAAE-----GNRSNISPIVPRNRSGAFLT-STPTRSGEGERDSE------NTQLPPM 1551
            | .|..::..|:     ||...::|..||.....|.. ....|...|.:|||      ::..||:
  Rat  1394 PNTAGPSSDTADVSKEGGNDEVLTPTRPRTTEDLFAAIHRSKRKVLGRKDSEDDHTRNHSPSPPV 1458

  Fly  1552 KQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLKKPAQATAT 1616
            .......:..:|:::.:....:.:|.|:..:||.|||.|.:: |....::||.|:||      :|
  Rat  1459 TPTGAAPSLASPKQVGSIQRSLKKSSTSSDNFKALLLKKGSR-SDTSARMSAAEMLK------ST 1516

  Fly  1617 PPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFA---NRR-----------MLRQGQFGS 1667
            .|         :...:.|:|:       .::..||.:|:   |||           |.|...|..
  Rat  1517 DP---------RFQRSRSEPS-------PEVPDSPSSFSPNKNRRAPEEWAKNEGLMPRSLSFSG 1565

  Fly  1668 P--SKTFAP--------KMR-----GPVNMVAAAAAPPRTDIMSTTIPEANSEEDHSNTSGGSRA 1717
            |  |::..|        .||     .|:.:::.....|..       |..|......:|:.|...
  Rat  1566 PRYSRSRTPPSAASSRYSMRNRIQSSPMTVISEGEGEPAE-------PADNKVRRTLDTTRGCSL 1623

  Fly  1718 SSEAGETV----------PSSFD 1730
            ...||:..          |:|.|
  Rat  1624 DRLAGQETDRGSPLCSEEPASVD 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	9/27 (33%)
Nhsl1	XP_017445312.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5311
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050