DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gukh and Nhs

DIOPT Version :9

Sequence 1:	NP_732393.1	Gene:	gukh / 53563	FlyBaseID:	FBgn0026239	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_001277455.1	Gene:	Nhs / 195727	MGIID:	2684894	Length:	1647	Species:	Mus musculus

Alignment Length:	1999	Identity:	423/1999 - (21%)
Similarity:	659/1999 - (32%)	Gaps:	650/1999 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPFVQRVVQPVNVAQATAASLGHASGRFHC-----TPGKCRNNNCINKQSPDVEVPNGHGSPTSL 60
            |||.:|:|:|                ::.|     .||...:.:..:.:.|....|.|.......
Mouse     1 MPFAKRIVEP----------------QWLCRQRRPAPGPDEDTSGGSVEPPPPLQPPGRREEAEA 49

  Fly    61 TRVLVHQAPEDQP-VPPAPAPMKKLKHHVEFLSTSPTRHQSQSLPNSRHPSQQRPA-LGRIASAP 123
            ..      ||:.| |||||.|:..|...:    .:|.....|....:|...::..| :...||||
Mouse    50 PE------PEEPPRVPPAPLPLPPLPPSL----PAPAEQDQQPPSEAREAGEESVAGVSEAASAP 104

  Fly   124 -QSPTAGSSKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIA 187
             ::..|.:..|:...:..::||..|:..||||:.:...|..:|.:|:.|:|....|...:|.|:.
Mouse   105 GETSEASAEAVLLMLDLCAVSNAALARVLRQLSDVARHACSLFQELESDIQLTHRRVWALQGKLG 169

  Fly   188 AVERRVCAYDPKTVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKEL--- 249
            :|:|.:...|||...||.|:|...::...::......|:.:|...|||..|.:|:..|.:.|
Mouse   170 SVQRVLSTLDPKQEAVPVSNLDIESKLSVYYRAPWHQQRNIFLPATRPPCVEELHRHARQSLQAL 234

  Fly   250 -----------------PVATGATATALASLAHSQSLIPSRSISFNGEVLSSDHEVLQLNGSTDT 297
                             |:...|........||||....::           |...|..|.:
Mouse   235 RREHRSRSDRREQRAAAPLPIAAPPLPAYPPAHSQRRREAK-----------DRHFLTFNST--- 285

  Fly   298 EDHLLCVSDFGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTS 362
                                       |.|:..|                   |.|....|..:.
Mouse   286 ---------------------------RSPSPTE-------------------CCHMAPWSRKSH 304

  Fly   363 LAIGENGILTPALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPNDINKDVPLNHR--LP 425
                         ||.....||:       |.|...:..||      :|:.::|....|..  ||
Mouse   305 -------------SPEDEDTDAM-------LGQRPKNPIHN------VPSTLDKQTNWNKALPLP 343

  Fly   426 SPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQTEGNN 490
            :|||:.||.|....:.:|.:|.:|..|.|..:.|.|.
Mouse   344 TPEEKMKQDAQVISSCIIPINVTGVGFDREASIRCSL---------------------------- 380

  Fly   491 LDDNVQTVSRRSRSRKVRGKRRNTIAGID---QKEIQDAANGNGESKNA--------SNATSPVA 544
                |.:.|...|.||:|  ||.||:||.   |:||....:.....:|.        ||..:..:
Mouse   381 ----VHSQSVLQRRRKLR--RRKTISGIPRRVQQEIDSDESPVARERNVIVHTNPDPSNTVNRRS 439

  Fly   545 PAQQAETTSSD---AKKSKKFGRSKSSDILKKESAALPY---------DKGKSTLTRLNSLKQWG 597
            ..:.:|..:.|   |..|::..|::....:   :|:|.:         |||.:..|.:.|    .
Mouse   440 GTRDSECQTEDILIAAPSRRRIRAQRGQSI---AASLSHSAGNISALADKGDTMFTPVVS----S 497

  Fly   598 RNRFKFMHRTGELGDQLDTSGCSSQNSSAEKADSHHGSPAGDNSKRDIDDECVVHHLVAQKSESR 662
            |.|.:.:.|.|..|...:.. ..::.|:.|:.:..    .||:.:  ..::|         ||:.
Mouse   498 RTRSRSLPREGNRGGDAEPK-VGAKPSAFEEGERF----VGDHER--TPNDC---------SEAP 546

  Fly   663 FSHERKPSYSSSEKSISVSSSGQL---------RGRLQLSSGPMAA---------------AHVK 703
            .|    ||....:.::.::.|..|         |||.:||.  |||               :.|.
Mouse   547 SS----PSTQEHQPALGLACSQHLHSPQQKLSERGRSRLSR--MAADSGSCDISSNSDTFGSPVH 605

  Fly   704 MRETATLNRQRRNGLHALAGKEEQPHSSSGNWSASSESGRASIGSEITMQPKSSASSTSLNVSSF 768
            ...||::.      |.:...::|...|||||||.|| |...|..|| |:.|.:|
Mouse   606 CISTASVL------LSSHMDQKEDHQSSSGNWSGSS-STCPSQTSE-TIPPAAS----------- 651

  Fly   769 QPGGAGSGPPSSMLSRRRFLNTSASSSV-----------------TSEGTAT------------- 803
             |...||....|.||.....|.:..:||                 |:..|:|
Mouse   652 -PPLTGSSHCDSELSLNTAPNANEDASVFVTEQYNDHLDKVRGHRTNSFTSTVADLLDDPNNSNT 715

  Fly   804 ---------------------PEL-QAEA---------GAYPGHLDD------ETSSAYSCDTEG 831
                                 ||. :|::         |.|...|:.      :|||.:|.||||
Mouse   716 SDSEWNYLHHHHDASCRQDFSPERPKADSLGCPSFTSMGTYDSFLEKSPSDKADTSSHFSVDTEG 780

  Fly   832 YYTSFHMDSGLRTLKE----------------EEPSVMPGTPLQTSLHTSSYSFGSQSNQTVLNA 880
            ||||.|.|.||:..|.                ..|..:|....|..|
Mouse   781 YYTSMHFDCGLKGNKTYVCHYAGLGPENGQGVGVPPALPDCAWQEYL------------------ 827

  Fly   881 ESEYELFGRGSTSTTTSSAGTVCTALMSGAASGPDVPERSSSLGKHSGQS--RSQSTSASSSTLE 943
              ::...||.|.|.....|             .|..|:|||||.|..|.:  ..:.....||...
Mouse   828 --DHRRQGRPSISFRKPKA-------------KPTPPKRSSSLRKSDGNADISEKKEPKISSGQH 877

  Fly   944 RSYSSSTIGSTLERTGTIKR--NVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLEGVERIE 1006
            ..:||..:...|:.:.|..|  |..:........:.:.:....:.|....:.|...| ||.|
Mouse   878 LPHSSREMKLPLDFSNTPSRVENANLPAKLDSSWINQSEHAIKEPQLDTPDISPFKD-EGAE--- 938

  Fly  1007 RIKQKTALTSKRIPSMCIITPTTSDDDEHQTNDPNRTL------TSLTI-----DVEHGEQDEDE 1060
                     |.....:.::       ::.:||||.|:|      |..|:     ..|..|....:
Mouse   939 ---------STHYADLWLL-------NDLKTNDPYRSLSNSSTATGTTVIECIKSPESSESQTSQ 987

  Fly  1061 AEQKTPTNSKDHNLNELK---------------------QTPTKALSGMFEKLRVKLVPGKSSPA 1104
            :|.:..|.|.....||.|                     :|||.:....|       ..|..||.
Mouse   988 SESRATTPSLPSVDNEYKLASPEKLAGLASPSSGYSSQSETPTSSFPTAF-------FSGPLSPG 1045

  Fly  1105 KNQMQPK-PANSSAVNDDELYDLAGEYVTIADISNNNNNNKNIGRRNTGMGIYYSNDIVSKRVEP 1168
            .::.:|| |...|::....|.|.|                           :..|.|.....:.|
Mouse  1046 GSKRKPKVPERKSSLQQPSLKDGA---------------------------LSLSKDFELPIIPP 1083

  Fly  1169 STSAVSEYVSLNE-----LPQHLRRHAVSS-----RSAPA------------------AESESCA 1205
            |...:|....||:     .|.|:..|..::     ||.||                  ::||...
Mouse  1084 SHLDLSALHVLNKPFHHRHPLHVFTHKQNTVGDMPRSNPAPSLAITPTVLKSVNLRSISKSEEVR 1148

  Fly  1206 QQQ-----LP-VEPAAATSQPPPLPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRRLRPNAE 1264
            |::     || :|..|||:                     |.:..||..|         .||:..
Mouse  1149 QKEGNNTDLPYLEENAATA---------------------ASVASLSPSK---------ARPHTA 1183

  Fly  1265 GKLVYDSDSLKRRKGAHTTFAP--GPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAK 1327
            .|      |:.|:..|..|..|  ...|.|.....|..::......|..||..|:.|.|:...:.
Mouse  1184 KK------SISRQYSAEDTLLPFLDSSVAEMGPEKHLEKNPNFDGKSHGDPETATSASSNLPDSN 1242

  Fly  1328 L---------------LLLTSGGLISGNRKVANVRPIVAKSPLSRNVSEMATYQA----TSYQDQ 1373
            :               :|..:.|..:|.::|:..||    |.|.   |:|..|.|    |..|.|
Mouse  1243 VMKEQIQMESELISENILSKNCGFSTGFQRVSASRP----SDLG---SKMIQYGASPDGTVQQGQ 1300

  Fly  1374 KQLLANRTNPFYETIAAPVANLMMPSPSGKSNSSTGSTATSSSSS-ASGQSGEEGYQRFSNIYEQ 1437
            |               ||..   :....||..|..|.|..::||: .:..|.:..:||..:.:..
Mouse  1301 K---------------APSG---VREEGGKPESVDGITLQANSSTRVTDISSQYKHQRVISRHHD 1347

  Fly  1438 VQPAPSTQPQEDATATPFQRSAPIYWTLQNRRSQPRPQPAGNVTCRDD----LYATPIRRA---- 1494
            ..|.......|.:|...|.....   ..:|..|...||.|.:.:..::    :..|.::.:
Mouse  1348 KVPVTIRHESEMSTVNSFPEKCS---EQENIASGISPQSASDNSRAEETQGSMDETSLKESSPSD 1409

  Fly  1495 DRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAF-LTSTPTRSGEGERDS------ENTQLP--- 1549
            |.:..|::..:...|||  ..:||..||.....| :.....|...|.:||      ..:::|
Mouse  1410 DSITSPLSEDSQAGAEG--VFVSPNKPRTTEDLFAVIHRSKRKVLGRKDSGDMSVRSKSRVPLGS 1472

  Fly  1550 ------PMKQPSRNWTDDAPERLNTCADRIGQSKTTLMDFKKLLLAKSAKASPVQRKVSAVELLK 1608
                  .:..||.|.|....:|......|..:...|..:..||||.|....|....::||.|:||
Mouse  1473 SSSSANSVTSPSSNVTAGTSQRSPGLIYRNAKKSNTSNEEFKLLLLKKGSRSDSSYRMSATEILK 1537

  Fly  1609 KPAQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKTFANRRML----RQGQFGSPS 1669
            .|         |.|..||:..|.:...|. :|.      .|:|.|.|...:.    |....|..|
Mouse  1538 SP---------VLPKPPGEFTAESPQSPD-DTH------QGTPGTEALSPLSPCSPRVNAEGFSS 1586

  Fly  1670 KTFAPKMRGPV--NMVAAAAAPPRTDI---MSTTIPEANSEEDHSNTSG 1713
            |.||......|  :.|...|:..|..:   :..|..:|.||.:..|:.|
Mouse  1587 KNFATSASARVGRSRVPPVASSSRYSVRCRLYNTPMQAISEGETENSDG 1635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	16/33 (48%)
Nhs	NP_001277455.1	NHS	437..1057	CDD:291922	152/728 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4544
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto95269
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5053
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.080