Protein Alignment gukh and nhs

DIOPT Version :9

• Sequence 1: NP_732393.1
• Gene: gukh / 53563
• FlyBaseID: FBgn0026239
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: XP_002934404.2
• Gene: nhs / 100498628
• XenbaseID: XB-GENE-5872334
• Length: 1561
• Species: Xenopus tropicalis
• Alignment Length: 1982
• Identity: 378/1982 - (19%)
• Similarity: 637/1982 - (32%)
• Gaps: 696/1982 - (35%)

  Fly     1 MPFVQRVVQPVNVAQATAASLGHASGRFHCTPGKCRNNNCINKQSPDVEVPNGHGSPTSLTRVLV 65
            |||.:|:|:|..:.: .|.:|...|    |    ||:....::|    :.|.|: |...|:.|:.
 Frog     1 MPFAKRIVEPQWLCR-HAITLQEGS----C----CRDQGEEHRQ----QHPRGN-SREELSGVVA 51

  Fly    66 HQAPEDQPVPPAPAPMKKLKHHVEFLSTSPTRHQSQSLPNSRHPSQQRPALGRIASAPQSPTAGS 130
                                                  |:.:.||.:|..:         |..|.
 Frog    52 --------------------------------------PSVQVPSDERETV---------PGDGK 69

  Fly   131 SKVVSGHEFDSISNITLSNALRQLASLVLIASDIFDDLQRDLQAVGERAGRVQRKIAAVERRVCA 195
            .|.|:..:..:.:|:.||..||||:.:...|..:|.:::.|:|.:|.|...:|.||:.|::.|.:
 Frog    70 DKDVAPLDLGAFNNVALSRILRQLSDMARHACSLFHEIEVDIQVIGRRVRTLQGKISNVQQVVTS 134

  Fly   196 YDPKTVTVPESDLLTFAQRKHHFETDKSFQQELFTGETRPLSVRQLYTEAGKELPVATGATATAL 260
            .|||..|||.|:|...::.:.:::.:...|:.:|...|||..|.:|:..|.:           :|
 Frog   135 LDPKQETVPVSNLDEESKLEVYYKANWHQQRNIFLPNTRPPCVEELHRHAKQ-----------SL 188

  Fly   261 ASLAHSQSL-IPSRSISFNGEVLSS------------------DHEVLQLNGSTDTEDHLLCVSD 306
            .|:...|.: ..:|...|.|.:.::                  :|.::|.|
 Frog   189 RSIRREQRIRADNRERRFQGSIFTAPPLPTYPAVHSLKRREVKEHHIVQFN-------------- 239

  Fly   307 FGNANRKLRTRIDAEIEIRLPAAIEDLRKWTSSEALGDVTVTPDCMHHVDTSVSTSLAIGENGIL 371
                    |||..:..|                           |.|                 |
 Frog   240 --------RTRSHSPTE---------------------------CCH-----------------L 252

  Fly   372 TP----ALSPSVLSADAVDALYAQNLSQAADSSRHNHHTQALIPN---------DINKDVPLNHR 423
            ||    |..|                 |..|........:..|||         :.||.:|
 Frog   253 TPWSRKAHPP-----------------QEEDDITLGQRPKNPIPNVPSTLDKQTNWNKALP---- 296

  Fly   424 LPSPEEQTKQIALKYPAEVISVNTSGKHFQRMCAARKSTSGGYAGGATAGSSSSTSPENAGQTEG 488
            ||:|||:.||.:....:.:|.:|.:|..|.|..:.|.|.
 Frog   297 LPTPEEKMKQESQVITSCIIPINVTGVGFDREASIRCSL-------------------------- 335

  Fly   489 NNLDDNVQTVSRRSRSRKVRGKRRNTIAGID---QKEIQDAANGNGESKNASNATSPVAPAQQAE 550
                  |.:.|...|.||:|  ||.||:||.   |:||....:.....:|....|:|       |
 Frog   336 ------VHSQSVLQRRRKLR--RRKTISGIPRRVQQEIDSDESPVARERNVIVHTNP-------E 385

  Fly   551 TTSSDAKKS-KKFGRSKSSDIL--KKESAALPYDKGKSTLTRLNSLKQWGRNRFKFMHRTG---- 608
            ..||..::| .:....::.|||  ......:...:|:.....|:             |..|
 Frog   386 LASSANRRSGTRDTECQTDDILITAPSRRRIRAQRGQGVAASLS-------------HSAGNIAA 437

  Fly   609 --ELGDQLDTSGCSSQ-------NSSAEKADSHHGSPAGDNSKRDIDDECVVHHLVAQKSESRFS 664
              |.|||:..:..||:       ......::.|.........:.|....|....|  :|.:.|.:
 Frog   438 LTESGDQMFKTTVSSRIRSRSLPREGVRASNDHDCCTQSSTYEEDCYMPCTERTL--KKDKDRLT 500

  Fly   665 HERKP-------SYSSSEKSISVSSSGQLRGRLQLSSGPMAAAHVKMRETATLNRQRRNG----- 717
            .:..|       |||....|..::.:.  |||.:||         :|.::.:.:....:.
 Frog   501 SQESPDHQPLGLSYSQHRHSPPLNLNE--RGRSRLS---------RMADSGSCDISSNSDTFGSP 554

  Fly   718 LHALAG----------KEEQPHSSSGNWSASSE------------------SGRASIGSEITMQ- 753
            :|:::.          :::...|||||||.||.                  :|.:...||:::.
 Frog   555 VHSISAAGVLLSTHIDQKDDHQSSSGNWSGSSSTCPSQTSETIPPAASPPLTGSSHCDSELSLNT 619

  Fly   754 -PKSSASSTSLNVSSFQPGGAGS---GPPSSMLSRRRFLNTSASSSVTSEGT------------- 801
             |.:...|....:..:......|   ...||..|....|....::|.||:..
 Frog   620 APHAGEDSNVFMIEQYSDDHIDSIRGHRASSFTSTVADLLDDPNNSNTSDSEWNYLHHHHDASCH 684

  Fly   802 ---ATPELQAE---------AGAYPGHLDDETS------SAYSCDTEGYYTSFHMDSGLRTLKEE 848
               :.|.|:.:         .|.|...|:...|      |.||.||||||||.|.|.||.|.:.
 Frog   685 QDFSPPHLKTDRLACPSFTSMGTYDSFLEKPASEKADSVSYYSVDTEGYYTSMHFDCGLNTSRS- 748

  Fly   849 EPSVMPGTPLQTSLHTSSYS-FGSQSNQ----TVLNAESEYELF-GRGSTSTTTSSAGTVCTALM 907
                          :..:|: .||:|:|    :.:|.::.::.: .:|:......|        .
 Frog   749 --------------YICNYAPTGSESDQGPGVSSVNTDNPWQCYMDQGNEGNQNIS--------F 791

  Fly   908 SGAASGPDVPERSSSLGKHSGQSR-----------SQSTSASSSTLERSYSSSTIGSTLERTGTI 961
            ....:.|..|:|.|||.|....:.           .|..:.||..::.....|.:...:|...|
 Frog   792 KKPKAKPTPPKRCSSLRKSDNNTDIPEKKEPKIVCGQQVNHSSREMKLPLEISNVPLRVENFAT- 855

  Fly   962 KRNVKMSPTKAGGEVTEKDDQQDQDQQQQLEFSESSDLEGVERIERIKQKTALTSKRIPSMCIIT 1026
                                    ..||::.::...|.|       :|....||          |
 Frog   856 ------------------------QHQQEIPWANQDDTE-------LKNTQFLT----------T 879

  Fly  1027 PTTSDDDEH---------------QTNDPNRTL------TSLTI-----DVEHGEQDEDEAEQKT 1065
            ..||..||.               :|:||.|:|      |..|:     ..|..|....::|.:.
 Frog   880 DITSFKDESGEQSHYADLWLLNDLKTSDPYRSLSNSSTATGTTVIECIKSPESSESQTSQSESRA 944

  Fly  1066 PTNSKDHNLNELKQTPTKALSGM--------------FEKLRVKLVPGKSSPAKNQMQPK-PANS 1115
            .:.|.....||.|.:..:.|:|:              .....:....|..||..::.:|| |...
 Frog   945 TSPSLPSVENEFKLSSPEKLAGLASPSSGYSSQSETPTSSFPIPFFSGPLSPGGSKRKPKVPERK 1009

  Fly  1116 SAV--------NDDEL-------YDLAGEYV---------TIADISNNNNNNKNIGRRNTGMGIY 1156
            |::        .:.||       .||:..:|         .:...|:||.|
 Frog  1010 SSLQHPSAKCGRELELPTIPPTHLDLSALHVLHKPLPYRPQMHAFSHNNQN-------------- 1060

  Fly  1157 YSNDIVSKRVEPS---TSAVSEYVSLNELPQHLRRHAVSSRSAPAAESESCAQQQLPVEPAAATS 1218
            .|.|.:.....|:   |.:|.:.|       |||  :|:.:...:.:.|:|....|
 Frog  1061 MSEDQIDSNSSPALAITPSVLKSV-------HLR--SVNKQHKKSKQRETCNLVCL--------- 1107

  Fly  1219 QPPPLPLGGRTQGVGDGVPMYAEIGELSEEKPLASAANRRLRPNAEGKLVYDSDSLKRRKGAHTT 1283
            |.|.:                 .:...:.||.:.::|.:               |:.|:.....|
 Frog  1108 QDPTI-----------------TVDTYTPEKAIVTSARK---------------SILRQFSTEET 1140

  Fly  1284 FAPGPYVKETESALHSAESAAAAIASSQDPSAASGAISSTKSAKLLLLTSGGLISGNRKVANVRP 1348
            ..|                       .:|.|....:..|....|..|.|..| |....|..|:..
 Frog  1141 ILP-----------------------YKDSSPVDTSPESMFFDKCALFTGHG-IYREEKGTNIFG 1181

  Fly  1349 IVAKSPLSRNVSEMATYQATSYQDQKQLLANRTNPFYE--------------TIAAPVANLMMPS 1399
             |.|.|.:..:     .|.|.:..|.:........:||              |....:.:.:|..
 Frog  1182 -VTKEPWTNEI-----VQETVFLVQPETTTTTFQEYYEKKNCGHAQDDQLKMTPDLHIQDDVMTI 1240

  Fly  1400 PSGKSNSSTGSTATSSSSSASGQSGEEGYQRFSNIYEQVQPAPSTQPQEDATATPFQRSAPIYWT 1464
            |...:.::||.|.   ..:|:|.|....|          :|..|...:.......|:...|..::
 Frog  1241 PEPVTGTTTGYTL---QDNAAGTSLMPNY----------EPDLSNNDKVPGNTLSFESELPTVYS 1292

  Fly  1465 LQNRRSQPRPQPAGNVTCRDDLYATPIRRADRLPRPVAAAAATAAEGNRSNISPIVPRNRSGAFL 1529
            |.:...:...:....:                   |..:|:|.....:..|:.....:..|
 Frog  1293 LSDECPEQESESVSGI-------------------PTKSASADKINDSSDNMEDTFCKESS---- 1334

  Fly  1530 TSTPTRSGEGERDSENTQLPPMKQPSRNWTDD---APERLNTCAD---RIGQSKTTLMDFKKLLL 1588
                        .||:..:.||.:.|.: |||   :|.:..|..|   .|.:||      :|:|.
 Frog  1335 ------------QSEDYLISPMSEDSAD-TDDVFVSPNKPRTTEDLFAAIHRSK------RKVLG 1380

  Fly  1589 AKSAKASPVQRKVSAVELLKKPAQATATPPVVKPSGPGQKVASAGSKPTINTSLKLLDLSGSPKT 1653
            .|.|..:.|:.|       .||...::.........||....||....|.|...|||.|....::
 Frog  1381 RKEAGDNSVKNK-------SKPITGSSGASASSQKSPGLIYRSAKKSNTSNEEFKLLLLKKGSRS 1438

  Fly  1654 FANRRMLRQGQFGSPSKTFAPKMRGPVNMVAAAAA------PPRTDIMSTTIPEANS--EEDHSN 1710
            ..:.||.......||   ..||..|.:.:.:::::      .|.:|..|...|.:..  .|..|.
 Frog  1439 DTSYRMSATEILKSP---VTPKSLGDLALDSSSSSEEGGQLSPGSDAFSPLSPCSPRVISEGFSP 1500

  Fly  1711 TSGGSRASSEAGET-VP-----SSFDLKRNFF 1736
            .||...|:|..|.: ||     |.:.::..|:
 Frog  1501 KSGTMSAASRVGRSRVPPAASSSRYSVRCRFY 1532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gukh	NP_732393.1	NHS	<818..>846	CDD:291922	17/33 (52%)
nhs	XP_002934404.2	NHS	392..1012	CDD:373703	132/710 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4480
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto105453
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050