Protein Alignment cmet and KIF14

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_055690.1
• Gene: KIF14 / 9928
• HGNCID: 19181
• Length: 1648
• Species: Homo sapiens
• Alignment Length: 1457
• Identity: 346/1457 - (23%)
• Similarity: 603/1457 - (41%)
• Gaps: 392/1457 - (26%)

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSI-----------HLADSHAEPYVFD---YVFDE----G 53
            |.:.|.::|||    .|...::::...:           |........:::|   :.|||    .
Human   357 SQVTVAVRVRP----FTKREKIEKASQVVFMSGKEITVEHPDTKQVYNFIYDVSFWSFDECHPHY 417

  Fly    54 ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSE- 117
            ||...|::::|..::....:|||..:||||||.|||:|||||..:.||::....:::|.|::.:
Human   418 ASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFSQVARKQ 482

  Fly   118 -TERDFLLRVGYIEIYNEKIYDLL------NKKNQDLKIHES---GNGI--VNVNCEECIITSEV 170
             .|..:.:.:.:.|:|||||:|||      .::.|.|::.|.   |..:  :::|    |::|..
Human   483 TQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMN----IVSSYA 543

  Fly   171 DLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDH---SDDDAVIQSVLNLVDLAGSE 232
            |:...|.||||:|....|.||::|||||::|.:::...|::.   .:.|..|.|.:||:||||||
Human   544 DIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSE 608

  Fly   233 RADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNR--FTNYRDSKLTRILQASLGGNAFTS 295
            |.......|.|||||..||||||.|..||.:|||.|:.|  |..||:|.||.:|:.|||||:.|:
Human   609 RCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTA 673

  Fly   296 IICTIKP--SIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKN 358
            :|.||.|  |.:||:.|||.:|.:|:.|....:|||     .|..:|.||:|....||...:|.:
Human   674 MIATISPAASNIEETLSTLRYANQARLIVNIAKVNE-----DMNAKLIRELKAEIAKLKAAQRNS 733

  Fly   359 EN----------------QQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLEL 407
            .|                :.|:...||.:. :|.::     ..:|.:|..:|           :|
Human   734 RNIDPERYRLCRQEITSLRMKLHQQERDMA-EMQRV-----WKEKFEQAEKR-----------KL 781

  Fly   408 AETGTTEDRIDQFPKVSHLPKPVFFH----------------TSNAGKRWDNIPKTINILGSLDI 456
            .||...:.....|...:|||..|..:                |:..||...|....|.:.|.| |
Human   782 QETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVL-I 845

  Fly   457 GTESNSISEEFLPAECIDFGSPRPDVL-KPMLTIRQL---------------------------- 492
            ..:..:|.........|..|..:..|. |.:|.|..|
Human   846 ADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRP 910

  Fly   493 --PDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQ--GLKEKLAEVTAQRDNLEQES 553
              .|.|:: :||...:..|.|:...|     ....|.|.:|.|  ..:|.:..:...::..:||.
Human   911 SGRDTPIS-EGPKDFEFAKNELLMAQ-----RSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQEL 969

  Fly   554 LAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKS 618
            .::|..|:                 |||..||.:|....|..::.|:.||.|        .||
Human   970 SSQKAAYE-----------------SKIKALEAELREESQRKKMQEINNQKA--------NHK-- 1007

  Fly   619 SKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQ--EDIA------GDSI 675
                              ||.|:|:..:|.:::..|.|...|.::|.:|  ||.:      .:::
Human  1008 ------------------IEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEAL 1054

  Fly   676 CNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAF-NLASSEIIQKATDCERLSKE 739
            ..:.:::.|.:..|:..:|:             |||..:|::.: ::..|.:||:|   ..:|.:
Human  1055 ETEKQKIAKEVQILQQNRNN-------------RDKTFTVQTTWSSMKLSMMIQEA---NAISSK 1103

  Fly   740 LSTSQNAFGQLQERYDALDQ-------QWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLES-RA 796
            |.| ...||    |:|..|:       :.:..:.||:|.... |..:.|...::|.||...| |.
Human  1104 LKT-YYVFG----RHDISDKSSSDTSIRVRNLKLGISTFWSL-EKFESKLAAMKELYESNGSNRG 1162

  Fly   797 RSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQN--HELTA-KIKE 858
            ..|........:.|.|  .|.::||:.|            .|.|.::..||..  |::.. .||.
Human  1163 EDAFCDPEDEWEPDIT--DAPVSSLSRR------------RSRSLMKNRRISGCLHDIQVHPIKN 1213

  Fly   859 LETNFEEMQREYDCLSNQLME---SVQENDA-----------LREEIKQRPTSHVEESMRSSGIS 909
            |.::.          |:.||:   ::..|.|           :...:.....|:.||...:..:.
Human  1214 LHSSH----------SSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLI 1268

  Fly   910 SDF-----------------DEQKQDINLLHQ-------FVQLSESVQQ-IELQHH--------S 941
            :.|                 ||:.|| ||...       .:|.:.:.:| :.|..|        :
Human  1269 NSFLKIYNGLFAISKAHEEQDEESQD-NLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCT 1332

  Fly   942 GISRLFRANQMKLDQSEPG--LKL-----CLESAEYIEEDNRQSDATEPI-----------CLKG 988
            .|:||  .::::.:..:.|  |:|     ||:.:..|:|  .|.:|.:.:           .|||
Human  1333 NIARL--EDELRQEVKKLGGYLQLFLQGCCLDISSMIKE--AQKNAIQIVQQAVKYVGQLAVLKG 1393

  Fly   989 ----FLKRHRFQIKRLSQEHVD-------MGEEKRLLDIISQLEQEIEEKSALMEATEATINEMR 1042
                ||:....:...:.:|.:|       :| .|.|||  |.||:..|.:..|..  :.|.||:.
Human  1394 SKLHFLENGNNKAASVQEEFMDAVCDGVGLG-MKILLD--SGLEKAKELQHELFR--QCTKNEVT 1453

  Fly  1043 EQM-TNLESAL--LEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTR-----------E 1093
            ::| ||....:  ||.....:|::.::||:   :::|.|    |::.:..|.|           |
Human  1454 KEMKTNAMGLIRSLENIFAESKIKSFRRQV---QEENFE----YQDFKRMVNRAPEFLKLKHCLE 1511

  Fly  1094 SSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGN 1158
            .:: |.::      ..|.||       ..::..|:|.:..:::..||..::.......:...:..
Human  1512 KAI-EIII------SALKGC-------HSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESR 1562

  Fly  1159 IARL-QTDFEEMSER---CLSMEVRLAEL------DEDTKQKQELLDRQAQKLSDDLCLIDQLQK 1213
            :..: ..:.|.:::.   |...|.....|      :::||:     :.|..|.|.    ||..:.
Human  1563 VTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKE-----EHQQSKSSG----IDGSKN 1618

  Fly  1214 KNA-QLVEQYHKATESLSLADAKPDQI 1239
            |.. :.|.:.|.::.::|..:..|.:|
Human  1619 KGVPKRVYELHGSSPAVSSEECTPSRI 1645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	126/350 (36%)
		SMC_prok_B	539..1431	CDD:274008	163/822 (20%)
		SMC_prok_B	1137..1926	CDD:274008	19/114 (17%)
		YhaN	1717..2182	CDD:443752
KIF14	NP_055690.1	Required for PRC1-binding	1..356
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Required for microtubule-binding with high affinity. /evidence=ECO:0000250|UniProtKB:L0N7N1	356..737		140/392 (36%)
		KISc_KIF1A_KIF1B	357..708	CDD:276816	128/358 (36%)
		Kinesin_assoc	705..823	CDD:465047	27/139 (19%)
		FHA_KIF14	794..901	CDD:438759	21/107 (20%)
		Required for CIT-binding	901..1648		175/882 (20%)
		Smc	<927..>1077	CDD:440809	41/212 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1600..1648		13/55 (24%)