DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and KIF3B

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_004789.1	Gene:	KIF3B / 9371	HGNCID:	6320	Length:	747	Species:	Homo sapiens

Alignment Length:	783	Identity:	222/783 - (28%)
Similarity:	352/783 - (44%)	Gaps:	169/783 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRPC---EPGLT---------SLWQVKERRSIHLADSHAEPYVFDYVFDEGASN 56
            |::.|::|.::.||.   |...:         .|.||..:.....|....:.:.||.|:|..|..
Human     5 KSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQ 69

  Fly    57 QEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---MGDEQNPGVMVLAAKEIFQQISSET 118
            .|::|...:.:|.:.:|||||||||||||.:||||||   .||.:..||:..:...||..||...
Human    70 FELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQ 134

  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGNGIVNVNCEECIITSEV-DLLRLLCLGNK 181
            .:.:|:|..|:|||.|:|.|||:| :.:.|::.|..:..|.|......:|..| ::..::.:||:
Human   135 NQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQ 199

  Fly   182 ERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKE 246
            .|:||.|||||.||||||||.|.||..:.....::.:....|||||||||||..:|||:|.||||
Human   200 NRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKE 264

  Fly   247 GGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTIKPSI--MEE 307
            ...||.||..|.|||.:|   .|.:.|:  ||||||||:||.||||||.|.::..:.|:.  :||
Human   265 ATKINLSLSALGNVISAL---VDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEE 326

  Fly   308 SQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL--------------------- 351
            :.:||.:|.|||.|:.||:|||...|| :::..:.||..||.:|
Human   327 TLTTLRYANRAKNIKNKPRVNEDPKDA-LLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSG 390

  Fly   352 --AEEERK----------------NENQQKVEHLERQIKHDMHKIICGHSL------SDKGQQKR 392
              .|||.:                .|.|:|:|..:|.|..| |.::....:      ..|.:..|
Human   391 GGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVED-HSLVAEEKMRLLKEKEKKMEDLR 454

  Fly   393 RRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIG 457
            |........|:.::..|:           |:....|.:..||:
Human   455 REKDAAEMLGAKIKAMES-----------KLLVGGKNIVDHTN---------------------- 486

  Fly   458 TESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDL-QMFTSL 521
             |...|.|:           .|.::.:.....|::..         ..:...:|..:| :.::||
Human   487 -EQQKILEQ-----------KRQEIAEQKRREREIQQ---------QMESRDEETLELKETYSSL 530

  Fly   522 EKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEE 586
            ::..:::.::::.|..||..|.|:..:|::|.:.|::..:..:.|:|...............|||
Human   531 QQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEE 595

  Fly   587 KLSTLKQTM-----------RIMEVENQ-------VAVGLEFEFEAHKKSS-------KLRVDDL 626
            |...:.:..           .|..:|||       .|||.:.....|.:.|       :.|.:::
Human   596 KSKIMNRAFFDEEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENI 660

  Fly   627 LSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLES 691
            :...|:..|          ..|||.     ||.  :|||:.: .|.|:.....:|::...:..||
Human   661 VLLELDMPS----------RTTRDY-----EGP--AIAPKVQ-AALDAALQDEDEIQVDASSFES 707

  Fly   692 KKN 694
            ..|
Human   708 TAN 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	142/340 (42%)
		Motor_domain	8..321	CDD:277568	139/333 (42%)
		Smc	<680..1449	CDD:224117	4/15 (27%)
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	139/334 (42%)
		Smc	<352..>614	CDD:224117	50/317 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..412		3/37 (8%)
		Globular	580..747		30/149 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..747		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910