DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and KIP2

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_015170.1	Gene:	KIP2 / 855948	SGDID:	S000006076	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	744	Identity:	198/744 - (26%)
Similarity:	300/744 - (40%)	Gaps:	231/744 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAKN---ASSIQVCIKVRP-------CEPGLTSLWQVKERRSIHLADS----------------H 40
            |.||   ..||.|.|:.:|       ...||.|....:.|.:.|...:                |
Yeast    93 SRKNDTYTGSITVTIRPKPRSVGTSRDHVGLKSPRYSQPRSNSHHGSNTFVRDPWFITNDKTIVH 157

  Fly    41 AE--PYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
            .|  .:.||:||....:|.||::|.:|.::...:.|||.||||||.|.||||:||.|:||..|::
Yeast   158 EEIGEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGNEQELGLI 222

  Fly   104 VLAAKEIFQQISSET---ERDFLLRVGYIEIYNEKIYDLL-------------------NKKNQ- 145
            .|:...:|..|..::   ::.|.:.:.|:|||||:|||||                   :|.|.
Yeast   223 PLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKSNSN 287

  Fly   146 ----DLKIHESGN------GIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAI 200
                :|||.:...      |:....||     |..:|||.:.:|:|.|.:|||:.|.||||||||
Yeast   288 GLGVELKIRDDSQYGVKVIGLTERRCE-----SSEELLRWIAVGDKSRKIGETDYNARSSRSHAI 347

  Fly   201 FKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLS 265
            ..|.:.|....:....:   |.|:|.||||||||  ||.: .|.|||..||||||.|..||..||
Yeast   348 VLIRLTSTNVKNGTSRS---STLSLCDLAGSERA--TGQQ-ERRKEGSFINKSLLALGTVISKLS 406

  Fly   266 E-----------------------NADNRFTN------YRDSKLTRILQASLGGNAFTSIICTI- 300
            .                       ||.|..|:      ||||||||:||.:|.|::..:.|||:
Yeast   407 ADKMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICTVD 471

  Fly   301 -KPSIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKV 364
             :.....|:.:||.||:|||.:.:......::|:.......:|.|::|:.:| ||:|
Yeast   472 TRNDAAAETMNTLRFASRAKNVALHVSKKSIISNGNNDGDKDRTIELLRRQL-EEQR-------- 527

  Fly   365 EHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKP 429
                |.|....::...|..|:....:           .::.::..||...|           |..
Yeast   528 ----RMISELKNRSNIGEPLTKSSNE-----------STYKDIKATGNDGD-----------PNL 566

  Fly   430 VFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPD 494
            ......|...::    |..|              .|:.|..:.:|....     :.|..:..||
Yeast   567 ALMRAENRVLKY----KLEN--------------CEKLLDKDVVDLQDS-----EIMEIVEMLP- 607

  Fly   495 LPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLA-EKE 558
                                .::.|.||..|       |||:.::.:.......||.:.:| ||.
Yeast   608 --------------------FEVGTLLETKF-------QGLESQIRQYRKYTQKLEDKIMALEKS 645

  Fly   559 RYDALE------KEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKK 617
            .:.|:.      .||..|:        |:.|.::|:                       .||.:.
Yeast   646 GHTAMSLTGCDGTEVIELQ--------KMLERKDKM-----------------------IEALQS 679

  Fly   618 SSKLRVDDLLSALLEKESTIESLQKSLDN 646
            :.:|| |..|..|:   :|.:|....:||
Yeast   680 AKRLR-DRALKPLI---NTQQSPHPVVDN 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	140/408 (34%)
		Motor_domain	8..321	CDD:277568	140/401 (35%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
KIP2	NP_015170.1	KISc_CENP_E	102..493	CDD:276825	140/401 (35%)
KIP2	NP_015170.1	SMC_prok_B	<445..>698	CDD:274008	75/373 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341348
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101662
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.630