Protein Alignment cmet and KIP1

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_009490.1
• Gene: KIP1 / 852216
• SGDID: S000000159
• Length: 1111
• Species: Saccharomyces cerevisiae
• Alignment Length: 1198
• Identity: 278/1198 - (23%)
• Similarity: 501/1198 - (41%)
• Gaps: 291/1198 - (24%)

  Fly     2 SAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLA-------------------DSHAEPYVFD 47
            :|.:.|:|.|.::.|.     .:..:::|:.|:.::                   .|..:.|.||
Yeast    46 AATSDSNIHVYVRCRS-----RNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFD 105

  Fly    48 YVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGD---------------E 97
            .||...:..:.||:..||:.:...:.|:|.||||||||.:||||||.||               .
Yeast   106 QVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLG 170

  Fly    98 QNPGVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKKNQD----------LKIHES 152
            ::.|::.....::|:::|| ..:::.:::.::|:|||.:.|||:....|          ::|.::
Yeast   171 EHAGIIPRVLVDLFKELSS-LNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDN 234

  Fly   153 GN---GIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKI---IIESRKSD 211
            .|   .|:....:|..|.|..:.|.||..|:.:|.|..|..|:.|||||.:|.|   |:|....|
Yeast   235 NNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKD 299

  Fly   212 HSDDDAVIQ-SVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNY 275
            |..:...:: ..||||||||||..:::||...|.:|.|.||||||.|..||.:|.:::::  ..|
Yeast   300 HGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNH--IPY 362

  Fly   276 RDSKLTRILQASLGGNAFTSIICTIKPS--IMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMK 338
            |:|||||:||.||||...|.||.||.|:  .|||:.|||.:|||||.|:..||||:.:|..|.:|
Yeast   363 RESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLK 427

  Fly   339 RLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGS 403
            ...:||    :||..:.:.:.|:|.:...:.|:  |:::                       |.|
Yeast   428 DYIQEI----EKLRNDLKNSRNKQGIFITQDQL--DLYE-----------------------SNS 463

  Fly   404 HLELAETGTTEDRID-QFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEF 467
            .|           || |..|:.:|.:.:        |::..     |.|..|||.....|..|:.
Yeast   464 IL-----------IDEQNLKIHNLREQI--------KKFKE-----NYLNQLDINNLLQSEKEKL 504

  Fly   468 LPA---ECIDFGSPRPDV-------LKPMLTIRQLPDLPL--TPKGPLTTDKIKKEI--QDLQMF 518
            :..   ..:||.:...::       |:.|..:.|..|..|  :.|...|...::.:|  |.||..
Yeast   505 IAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTL 569

  Fly   519 TSLE---KHFEVECEEV-QGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANS 579
            .:|:   .::..:|.|| :|:.|:|..      |:.    ..|.::|:..|.:.     |...|.
Yeast   570 NTLQGSLNNYNSKCSEVIKGVTEELTR------NVN----THKAKHDSTLKSLL-----NITTNL 619

  Fly   580 KISELEEKLSTLKQTMRIMEVE---------NQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKES 635
            .::::.|.:.::..::.|.:.:         |::       :::|::..|...:|:.|.|   :|
Yeast   620 LMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEI-------YQSHQQFLKNLQNDIKSCL---DS 674

  Fly   636 TIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLI--ADLESKKNSCEC 698
            ...|:..|::.::::...|....::|             |.|:.....|||  .|||.||
Yeast   675 IGSSILTSINEISQNCTTNLNSMNVL-------------IENQQSGSSKLIKEQDLEIKK----- 721

  Fly   699 DQLRLEIVSVRDKLESVESAFNLASSEIIQKATD-CERLSKELSTSQN-AFGQLQERYDALDQQ- 760
              |:.::::.|    .:.:.||...:|:.:...| ..|...|.....| ....|:::...|||.
Yeast   722 --LKNDLINER----RISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDI 780

  Fly   761 WQAQQA---------------GITTLHEKHEHVQEKYQKLQEEYE------------QLESRARS 798
            ||...:               .|.:|....|:..:...:..|.:.            .:.|:.||
Yeast   781 WQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRS 845

  Fly   799 ASSAEF---------QRLQNDNT-----------KFQ----ADIASLNERLEEAQNMLTEVQNSE 839
            ....||         :...:|||           |||    :|||..||::   .:::.|:|:..
Yeast   846 LPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKI---MSLIDEIQSQI 907

  Fly   840 STVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMR 904
            .|:.             .|...|...:...::.|.|.::....||             .::.|..
Yeast   908 ETIS-------------NENNINLIAINENFNSLCNFILTDYDEN-------------IMQISKT 946

  Fly   905 SSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAE 969
            ...:.|:..|:.|.:.:|...:..:.|::: .|..|:       ..:..:.::.|.|....:...
Yeast   947 QDEVLSEHCEKLQSLKILGMDIFTAHSIEK-PLHEHT-------RPEASVIKALPLLDYPKQFQI 1003

  Fly   970 YIEEDNRQSDAT--EPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDII--SQLEQEIEEKSAL 1030
            |.:.:|:..|.|  ...|:........|.:.:.|.:......::.|..::  ..:......:|..
Yeast  1004 YRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKT 1068

  Fly  1031 MEATEATINEMREQMTNLESALLEKSVI 1058
            :..||.|   .||...||:.....:.::
Yeast  1069 LPNTEGT---GRESQNNLKRRFTTEPIL 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	125/365 (34%)
		SMC_prok_B	539..1431	CDD:274008	100/589 (17%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	131/376 (35%)
		235kDa-fam	<423..>948	CDD:130673	120/655 (18%)
		AAA_13	<562..>741	CDD:463796	43/227 (19%)