DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and TES

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001319676.1	Gene:	TES / 823396	AraportID:	AT3G43210	Length:	938	Species:	Arabidopsis thaliana

Alignment Length:	1120	Identity:	282/1120 - (25%)
Similarity:	461/1120 - (41%)	Gaps:	284/1120 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPC---EPGLTSL--WQVKERRSIHL----ADSHAEPYVFDYVFDEGASNQEVFDRMA 64
            |.|.:::||.   |.....|  |:..:..:|..    .|.....|.||.||:...:.|||::..:
plant    30 ILVTVRMRPLNWREHAKYDLIAWECPDDETIVFKNPNPDKAPTKYSFDKVFEPTCATQEVYEGGS 94

  Fly    65 KHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYI 129
            :.:..:.:.|.|.|||||||||||||:||.      ||.....|:|::.|....||.|:|:|..:
plant    95 RDVALSALAGTNATIFAYGQTSSGKTFTMR------GVTESVVKDIYEHIRKTQERSFVLKVSAL 153

  Fly   130 EIYNEKIYDLLNKKNQDLK-IHESGNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNER 193
            |||||.:.||||:....|: :.:...|.:..|..|.::.|...|..|:.:...:|.||||.:|::
plant   154 EIYNETVVDLLNRDTGPLRLLDDPEKGTIVENLVEEVVESRQHLQHLISICEDQRQVGETALNDK 218

  Fly   194 SSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLS 258
            |||||.|.::.|.|...:.:.......:.||||||||||||.||.|.|.|||||.|||:|||.|:
plant   219 SSRSHQIIRLTIHSSLREIAGCVQSFMATLNLVDLAGSERAFQTNADGLRLKEGSHINRSLLTLT 283

  Fly   259 NVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSI--MEESQSTLSFATRAKKI 321
            .||:.||.........|||||||||||.||||||.|:|||||.|::  :|:::.|||||..||::
plant   284 TVIRKLSSGRKRDHVPYRDSKLTRILQNSLGGNARTAIICTISPALSHVEQTKKTLSFAMSAKEV 348

  Fly   322 RIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKN---------ENQQKVEHLERQIKHDMHK 377
            ....:||.:||:..::|.|::::..|:.:|...|..:         |.:.|::.:|.::|
plant   349 TNCAKVNMVVSEKKLLKHLQQKVAKLESELRSPEPSSSTCLKSLLIEKEMKIQQMESEMK----- 408

  Fly   378 IICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWD 442
                       :.||:|    ..:.|.|:|...........:....|.:.:.:.:|
plant   409 -----------ELKRQR----DIAQSELDLERKAKERKGSSECEPFSQVARCLSYH--------- 449

  Fly   443 NIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDK 507
                           |:..||..:.:|:........|.|      .:||    .||...|...
plant   450 ---------------TKEESIPSKSVPSSRRTARDRRKD------NVRQ----SLTSADPTAL-- 487

  Fly   508 IKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRA 572
                :|::::   ||||           ::||.|...|             ..|.:.|||||.:.
plant   488 ----VQEIRL---LEKH-----------QKKLGEEANQ-------------ALDLIHKEVTSHKL 521

  Fly   573 DNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEK---- 633
            .::.|..|::::   ||.::...:...:..::.||    .:|:.|....|::....|.|||
plant   522 GDQQAAEKVAKM---LSEIRDMQKSNLLTEEIVVG----DKANLKEEINRLNSQEIAALEKKLEC 579

  Fly   634 -ESTIESLQKSL--DNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNS 695
             ::||:.|..|.  |..|.|.....|:..:|.............|...|..|    :..|:|
plant   580 VQNTIDMLVSSFQTDEQTPDFRTQVKKKRLLPFGLSNSPNLQHMIRGPCSPL----SGTENK--- 637

  Fly   696 CECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQ 760
                          |...:|.||                      :::..:||....:.|  |.:
plant   638 --------------DPESNVVSA----------------------NSAPVSFGATPPKRD--DNR 664

  Fly   761 WQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERL 825
            .:.|....|.:                        :|.|:|.:.:|:   |..::      |...
plant   665 CRTQSREGTPV------------------------SRQANSVDIKRM---NRMYK------NAAE 696

  Fly   826 EEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREE 890
            |..:|:.:.|...:..|.||:.|...|..::.|||.|......|||.
plant   697 ENIRNIKSYVTGLKERVAKLQYQKQLLVCQVLELEANETGAASEYDA------------------ 743

  Fly   891 IKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFR---ANQM 952
                    .:||.....:.  |:||::.|.:|.....:|       :.|.:....||:   |:|:
plant   744 --------TDESQMDWPLC--FEEQRKQIIMLWHLCHIS-------IIHRTQFYMLFKGDPADQI 791

  Fly   953 -----------------KLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHR-FQIKR 999
                             :|..:.|.| |..|.|.|:....|.            ||:.| :..||
plant   792 YMEVELRRLTWLEQHLAELGNASPAL-LGDEPASYVASSIRA------------LKQEREYLAKR 843

  Fly  1000 LSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVED 1064
            ::.:   :|.|:|     ..|..:.:......:..:..||::.....|::. :.|.:.|:.|:..
plant   844 VNTK---LGAEER-----EMLYLKWDVPPVGKQRRQQFINKLWTDPHNMQH-VRESAEIVAKLVG 899

  Fly  1065 YQRQIESLEKQNAEM 1079
            :....|::.|:..|:
plant   900 FCDSGETIRKEMFEL 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	138/330 (42%)
		Motor_domain	8..321	CDD:277568	138/323 (43%)
		Smc	<680..1449	CDD:224117	73/421 (17%)
		TMPIT	779..>867	CDD:285135	18/87 (21%)
		Smc	1042..1910	CDD:224117	7/38 (18%)
TES	NP_001319676.1	KISc_CENP_E	29..348	CDD:276825	138/323 (43%)
		Smc	<364..>585	CDD:224117	57/314 (18%)
		DUF3490	755..919	CDD:403272	37/189 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47968
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870