DRSC/TRiP Functional Genomics Resources

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Protein Alignment cmet and KIF18A

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_112494.3 Gene:KIF18A / 81930 HGNCID:29441 Length:898 Species:Homo sapiens


Alignment Length:987 Identity:238/987 - (24%)
Similarity:395/987 - (40%) Gaps:272/987 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 IQVCIKVRPCEPGLTSLWQVKER-----RSIHLADSHA---EP---------------------- 43
            ::|.::|||        ...||:     :.:|:.|.|.   :|                      
Human    12 MKVVVRVRP--------ENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQ 68

  Fly    44 -----YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
                 :|||.||||.::..|||:...|.|:.:.:.|:|.|:.|||.|.:|||:||:|....||||
Human    69 NKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVM 133

  Fly   104 VLAAKEIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCEECIIT 167
            .|....:::.:.. :.|:.....|.|:|:|||:|.|||         ..||...|..:.::.::.
Human   134 YLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLL---------VNSGPLAVREDTQKGVVV 189

  Fly   168 ---------SEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVL 223
                     |..::|.||..|||.||...|:||..||||||:|:|.:..:....|.:..|..:.:
Human   190 HGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKM 254

  Fly   224 NLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSEN-ADNRFTNYRDSKLTRILQAS 287
            :|:||||||||..:||:|.|..||.:||:|||.|.|||.:|::: ..|:...||:|||||:|:.|
Human   255 SLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDS 319

  Fly   288 LGGNAFTSIICTIKPS--IMEESQSTLSFATRAKKIR--IKPQV----NEMVSDATMMKRLEREI 344
            ||||..|.:|..:.||  ..:::.:||.:|.|||.|:  :|..|    |.:.....:....:.||
Human   320 LGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEI 384

  Fly   345 KVLKDKL-AEEERK---NENQQ-----------------------------------KVEHL--E 368
            .:||:|| |.||:|   |||.|                                   |:|.|  |
Human   385 LLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKE 449

  Fly   369 RQIK-------HDMHKIICGHSLSDKGQQKR-RRTWCPTASGSHLELAETGTTEDRIDQFPKVSH 425
            .::|       |...:::|.....:|...|| .|........|:||...    |:.:.||     
Human   450 NELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRR----EEELKQF----- 505

  Fly   426 LPKPVFFHTSNAGKRW-DNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTI 489
                      :....| ..:.|.:.:|      :::..|.:|                ||..|..
Human   506 ----------DENTNWLHRVEKEMGLL------SQNGHIPKE----------------LKKDLHC 538

  Fly   490 RQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESL 554
            ..|         .|....:|.:|:.:.....|::....:.|.|  |...|..:..|...|::..|
Human   539 HHL---------HLQNKDLKAQIRHMMDLACLQEQQHRQTEAV--LNALLPTLRKQYCTLKEAGL 592

  Fly   555 AE-------KERYDALEKEVTSLRADNEAANSKISELE--EKLSTLKQTMRIMEV--------EN 602
            :.       ||....:|::...:.||..|...|.::|.  ..|.|..|...:..:        .|
Human   593 SNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTN 657

  Fly   603 QVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIES-------LQKSLDNLTRDVLRNSKEGHM 660
            .|.:..|      |::.:    .|:.:.|:.:.|::|       |..||          |||...
Human   658 LVKIPTE------KRTRR----KLMPSPLKGQHTLKSPPSQSVQLNDSL----------SKELQP 702

  Fly   661 LSIAPEQEDIAGDSICNKCEELEKLIA------------DLESKKNSCECDQLRLEIVSVRDK-- 711
            :...||.        |.|..:....:.            .:.|..||..|.::..|:....::  
Human   703 IVYTPED--------CRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRK 759

  Fly   712 ---LESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHE 773
               .|.::|.|.:...   .|::.|:...:|...:.|.  .:.:|.|         .:..:|.|.
Human   760 ECGQEDLDSTFTICED---IKSSKCKLPEQESLPNDNK--DILQRLD---------PSSFSTKHS 810

  Fly   774 KHEHVQEKYQKLQEEYEQLES---RARSASSAEFQRLQNDNTKFQADIAS-LNERLEEAQNMLTE 834
            .      ....:...|..:.:   |.|..:|:      ..|:...||:.| ..:|:.:..:....
Human   811 M------PVPSMVPSYMAMTTAAKRKRKLTSS------TSNSSLTADVNSGFAKRVRQDNSSEKH 863

  Fly   835 VQNSESTVEKLR 846
            :|.::.|:|..|
Human   864 LQENKPTMEHKR 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 128/372 (34%)
Motor_domain 8..321 CDD:277568 125/359 (35%)
Smc <680..1449 CDD:224117 29/188 (15%)
TMPIT 779..>867 CDD:285135 13/72 (18%)
Smc 1042..1910 CDD:224117
KIF18ANP_112494.3 KISc_KIP3_like 11..355 CDD:276821 125/359 (35%)
Kinesin 17..355 CDD:278646 124/354 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..690 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..871 8/46 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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