Protein Alignment cmet and KIF18A

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_112494.3
• Gene: KIF18A / 81930
• HGNCID: 29441
• Length: 898
• Species: Homo sapiens
• Alignment Length: 987
• Identity: 238/987 - (24%)
• Similarity: 395/987 - (40%)
• Gaps: 272/987 - (27%)

  Fly     9 IQVCIKVRPCEPGLTSLWQVKER-----RSIHLADSHA---EP---------------------- 43
            ::|.::|||        ...||:     :.:|:.|.|.   :|
Human    12 MKVVVRVRP--------ENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQ 68

  Fly    44 -----YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
                 :|||.||||.::..|||:...|.|:.:.:.|:|.|:.|||.|.:|||:||:|....||||
Human    69 NKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVM 133

  Fly   104 VLAAKEIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCEECIIT 167
            .|....:::.:.. :.|:.....|.|:|:|||:|.|||         ..||...|..:.::.::.
Human   134 YLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLL---------VNSGPLAVREDTQKGVVV 189

  Fly   168 ---------SEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVL 223
                     |..::|.||..|||.||...|:||..||||||:|:|.:..:....|.:..|..:.:
Human   190 HGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKM 254

  Fly   224 NLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSEN-ADNRFTNYRDSKLTRILQAS 287
            :|:||||||||..:||:|.|..||.:||:|||.|.|||.:|::: ..|:...||:|||||:|:.|
Human   255 SLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDS 319

  Fly   288 LGGNAFTSIICTIKPS--IMEESQSTLSFATRAKKIR--IKPQV----NEMVSDATMMKRLEREI 344
            ||||..|.:|..:.||  ..:::.:||.:|.|||.|:  :|..|    |.:.....:....:.||
Human   320 LGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEI 384

  Fly   345 KVLKDKL-AEEERK---NENQQ-----------------------------------KVEHL--E 368
            .:||:|| |.||:|   |||.|                                   |:|.|  |
Human   385 LLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKE 449

  Fly   369 RQIK-------HDMHKIICGHSLSDKGQQKR-RRTWCPTASGSHLELAETGTTEDRIDQFPKVSH 425
            .::|       |...:::|.....:|...|| .|........|:||...    |:.:.||
Human   450 NELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRR----EEELKQF----- 505

  Fly   426 LPKPVFFHTSNAGKRW-DNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTI 489
                      :....| ..:.|.:.:|      :::..|.:|                ||..|..
Human   506 ----------DENTNWLHRVEKEMGLL------SQNGHIPKE----------------LKKDLHC 538

  Fly   490 RQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESL 554
            ..|         .|....:|.:|:.:.....|::....:.|.|  |...|..:..|...|::..|
Human   539 HHL---------HLQNKDLKAQIRHMMDLACLQEQQHRQTEAV--LNALLPTLRKQYCTLKEAGL 592

  Fly   555 AE-------KERYDALEKEVTSLRADNEAANSKISELE--EKLSTLKQTMRIMEV--------EN 602
            :.       ||....:|::...:.||..|...|.::|.  ..|.|..|...:..:        .|
Human   593 SNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTN 657

  Fly   603 QVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIES-------LQKSLDNLTRDVLRNSKEGHM 660
            .|.:..|      |::.:    .|:.:.|:.:.|::|       |..||          |||...
Human   658 LVKIPTE------KRTRR----KLMPSPLKGQHTLKSPPSQSVQLNDSL----------SKELQP 702

  Fly   661 LSIAPEQEDIAGDSICNKCEELEKLIA------------DLESKKNSCECDQLRLEIVSVRDK-- 711
            :...||.        |.|..:....:.            .:.|..||..|.::..|:....::
Human   703 IVYTPED--------CRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRK 759

  Fly   712 ---LESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHE 773
               .|.::|.|.:...   .|::.|:...:|...:.|.  .:.:|.|         .:..:|.|.
Human   760 ECGQEDLDSTFTICED---IKSSKCKLPEQESLPNDNK--DILQRLD---------PSSFSTKHS 810

  Fly   774 KHEHVQEKYQKLQEEYEQLES---RARSASSAEFQRLQNDNTKFQADIAS-LNERLEEAQNMLTE 834
            .      ....:...|..:.:   |.|..:|:      ..|:...||:.| ..:|:.:..:....
Human   811 M------PVPSMVPSYMAMTTAAKRKRKLTSS------TSNSSLTADVNSGFAKRVRQDNSSEKH 863

  Fly   835 VQNSESTVEKLR 846
            :|.::.|:|..|
Human   864 LQENKPTMEHKR 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	125/359 (35%)
		SMC_prok_B	539..1431	CDD:274008	62/353 (18%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	125/359 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..690		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..871		8/46 (17%)