DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and AT2G21300

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001031385.1	Gene:	AT2G21300 / 816669	AraportID:	AT2G21300	Length:	862	Species:	Arabidopsis thaliana

Alignment Length:	920	Identity:	238/920 - (25%)
Similarity:	384/920 - (41%)	Gaps:	204/920 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRP---------------CEPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQE 58
            |.|.:::||               |....|.|:    |.::....:....|.||.|:......::
plant    25 ILVLVRLRPLNEKEILANEAADWECINDTTVLY----RNTLREGSTFPSAYSFDRVYRGECPTRQ 85

  Fly    59 VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFL 123
            |::...|.:..:.::|.|.:|||||||||||||||      .|:...|..:||..|....:|.|:
plant    86 VYEDGPKEVALSVVKGINSSIFAYGQTSSGKTYTM------SGITEFAVADIFDYIFKHEDRAFV 144

  Fly   124 LRVGYIEIYNEKIYDLLNKKNQDLKIHES-GNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGE 187
            ::...||||||.|.|||:..:..|::.:. ..|.......|..:.....|..|:.:...:|.:||
plant   145 VKFSAIEIYNEAIRDLLSPDSTPLRLRDDPEKGAAVEKATEETLRDWNHLKELISVCEAQRKIGE 209

  Fly   188 TNMNERSSRSHAIFKIIIES--RKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHI 250
            |::||||||||.|.|:.:||  |:....::...:.:.:|.:||||||||.|..:.|||||||.||
plant   210 TSLNERSSRSHQIIKLTVESSAREFLGKENSTTLMASVNFIDLAGSERASQALSAGARLKEGCHI 274

  Fly   251 NKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKP--SIMEESQSTLS 313
            |:|||.|..||:.|| |......||||||||||||..|||||.|:|:||:.|  |.:|::::||.
plant   275 NRSLLTLGTVIRKLS-NGRQGHINYRDSKLTRILQPCLGGNARTAIVCTLSPARSHVEQTRNTLL 338

  Fly   314 FATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKI 378
            ||..||::..|.|:|.::||..::|:|:||:..|:.:|........:..
plant   339 FACCAKEVTTKAQINVVMSDKALVKQLQRELARLESELRNPAPATSSCD---------------- 387

  Fly   379 ICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTED----RIDQFPK-VSH--LPKPVFFHTSN 436
             ||.:|..|..|.::         ...:|||.....|    |::.|.| |.|  ..|....|..|
plant   388 -CGVTLRKKDLQIQK---------MEKQLAEMTKQRDIAQSRLEDFMKMVEHDASSKAGTPHFRN 442

  Fly   437 AGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPD--------VLKPMLT----I 489
            ...:|                 |..|:||        ..|...||        ...|:.|    :
plant   443 RTNKW-----------------EDGSVSE--------ISGVVDPDRTSFISDGTSTPLSTARAHV 482

  Fly   490 RQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESL 554
            |...|           |.:::|:.........|::    |:|||.:  ::.|.|...:|
plant   483 RSHSD-----------DDLEEEMSPRHSGDQSEEY----CKEVQCI--EMEESTRDINN------ 524

  Fly   555 AEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMR---------IMEVENQVAVGLEF 610
            ..:||.||     .:|...|..||.:....:.::.:..:::|         .|...:.....||.
plant   525 DSEERTDA-----ETLLGHNAEANGETGSAQHRIPSSVRSVRRRKSWSRGDTMTGTSTPPDALET 584

  Fly   611 EF----EAH----------KKSSKLRVDDLLS-------------ALLEKESTIESLQKSLDNLT 648
            ::    |.|          .....||.|.:.|             .|:.:|..|.|::..::.|.
plant   585 DYRGRPEGHGFAFPDLEFGSGGKLLRNDSMTSRGSDSTEAHSIGTPLVGEEGGITSIRSFVEGLK 649

  Fly   649 RDVLRNSKEGHM---LSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLR---LEIVS 707
            ..|......|.|   :.:...:|:::| ::.|..||.|:....:.....:|....:.   ..::.
plant   650 EMVSDPENSGKMRKDIGVDAMEEEVSG-TMTNWSEEFERQREQILGLWQTCHVSLVHRTYFFLLF 713

  Fly   708 VRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLH 772
            ..|:.:|:.....|                :.||..:.:|.|....::.  .|.....:.:..||
plant   714 TGDQADSIYIGVEL----------------RRLSFMKESFSQGNHAFER--GQTLTIASSLKALH 760

  Fly   773 EKHEHVQEKYQK--LQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEV 835
            .:...:.:...|  ..||.::|..:...|.:::.:|||            |..:|....|.:|..
plant   761 RERRMLSKLVGKRFTGEERKRLYQKFGIAVNSKRRRLQ------------LANQLWSKPNDITHA 813

  Fly   836 QNSESTVEKL 845
            ..|.:.|.||
plant   814 VESAAVVAKL 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	131/338 (39%)
		Motor_domain	8..321	CDD:277568	129/331 (39%)
		Smc	<680..1449	CDD:224117	30/171 (18%)
		TMPIT	779..>867	CDD:285135	16/69 (23%)
		Smc	1042..1910	CDD:224117
AT2G21300	NP_001031385.1	KISc_CENP_E	24..346	CDD:276825	129/331 (39%)
		Kinesin	30..346	CDD:278646	127/326 (39%)
		DUF3490	685..844	CDD:288820	28/169 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47968
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870