DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and si:dkey-26i13.8

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_001337836.4	Gene:	si:dkey-26i13.8 / 797363	ZFINID:	ZDB-GENE-090312-134	Length:	991	Species:	Danio rerio

Alignment Length:	1271	Identity:	293/1271 - (23%)
Similarity:	491/1271 - (38%)	Gaps:	358/1271 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRP-----CEPGLTSLWQVKERRSIHLAD-------------SHAEPYVFDYVFDEGAS 55
            :.|.:::||     .|.|.|.:....:.:.:.|.|             |..:.|:||..||..|:
Zfish    13 LTVALRIRPLNEAEIEEGATIVAHKIDNQMVVLMDPCEDSDNVLRAHRSREKTYMFDLAFDYTAT 77

  Fly    56 NQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETE- 119
            .::|:....|:::...:.|:|.|:||||.|.:|||:||:|.:..||:.:....::|:.|...||
Zfish    78 QEDVYVATTKNLIDGVIAGYNATVFAYGPTGAGKTHTMLGLDSEPGIYIRTLNDLFRAIEDSTED 142

  Fly   120 RDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKER 183
            .|..:.:.|||||||.|.||||..:..|::.|.|.|.:.: ...|....:..:::.||..|||:|
Zfish   143 LDCSVYMSYIEIYNEMIRDLLNPSSGYLELREDGKGEIRIAGITEFSTCNAKEIMALLTKGNKQR 207

  Fly   184 TVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGG 248
            |...|..|:.|||||||.::.::.:......::.|....|.:|||||:|||.||..||.|:|||.
Zfish   208 TQESTAANKTSSRSHAILQVTVKQKSRVKDINEEVRVGKLFMVDLAGTERASQTQNRGKRMKEGA 272

  Fly   249 HINKSLLFLSNVIKSLSENADN--RFTNYRDSKLTRILQASLGGNAFTSIICTIKP--SIMEESQ 309
            |||:|||.|:|.|.:|||....  :|.|||||||||:|:.:||||:.|.:|..|.|  |..|||:
Zfish   273 HINRSLLALANCINALSEKGGKGAQFVNYRDSKLTRLLKDALGGNSRTVMITHISPASSNFEESR 337

  Fly   310 STLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNE--NQQKVEHLERQIK 372
            :||.:|.:||.||.|.:.|.|    .:...|.:..:::.|..:|.||...  :||..:.|
Zfish   338 NTLVYADKAKNIRTKVKRNLM----NVSYHLAQYTRIIADLRSEIERLRAKIDQQSQDQL----- 393

  Fly   373 HDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNA 437
                          ||                 |.|:....:..:.|:   ||
Zfish   394 --------------KG-----------------EKADIRNIQAEVQQY---SH------------ 412

  Fly   438 GKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGP 502
                          |.:.:      :.|:.|.|            .:..:.||:
Zfish   413 --------------GEMAL------LQEQLLSA------------FREQMEIRR----------- 434

  Fly   503 LTTDKIKKEIQDLQMFTSLEKHF----EVECEEVQGLKEKLAEVTAQRDNL----EQESLAEKER 559
               ..::.|..::::.....:|.    :.|.:..:..:|| .|::.|:.:.    ||||:.|:.:
Zfish   435 ---SLMELENCNMELHIDTSRHLLTISDWERDRARARREK-DELSGQKKHTDKEEEQESMPEEPQ 495

  Fly   560 Y-DALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRV 623
            | .|..:|:..|.|:.........||||||..:|                       .||||:.
Zfish   496 YVTAAREEIGPLLAEQRKTMELKRELEEKLLNMK-----------------------LKSSKIE- 536

  Fly   624 DDLLSALLEKESTIESLQKSLDNL-TRDVLRNSKEGHMLSIAPEQEDIAGDSIC--NKCEELEKL 685
                          |.|.|.:.|. .||:|....:.|.|.:  |:.:|....:|  |.....:.:
Zfish   537 --------------ELLPKRISNTEQRDILMLLCKVHELEL--EKTEIQSAVLCKENVLRTKDFI 585

  Fly   686 IADLESKKNSCECDQLRLEIVSVRDK----LESVESAFNLASSEIIQKATDCERLSKELSTSQNA 746
            |...|.::..|: |.:..:.:.:.|:    .|.::..::|...|:.....| :.|:....|:.|
Zfish   586 IQRHEQQRTLCD-DIIHQQKMLIEDQGLCVPEGLQELYSLYFGELSDGIID-QILNLHTFTTNN- 647

  Fly   747 FGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDN 811
               |..|...||.        |:.|.|     .:|.::...::..|:...|.:||:......:.|
Zfish   648 ---LNARQLRLDV--------ISNLEE-----ADKAEQSNVKFSPLDKHPRDSSSSGLDYDSDTN 696

  Fly   812 TKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQ 876
            ..|::               |:::        |.|.|:|..:                    |..
Zfish   697 RVFKS---------------LSKI--------KPRRQHHSSS--------------------SQT 718

  Fly   877 LMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHS 941
            ||..|   .|:::.....||..|..                  :.|.:.|..::|:..|..:..|
Zfish   719 LMRKV---CAVKDSTPICPTESVSP------------------DTLREIVSDTKSISVIAAKRRS 762

  Fly   942 GISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVD 1006
            .:       |.|.:....|:.|.......:..|:          |...|.....:::|..|.|..
Zfish   763 RL-------QAKSNSRMAGMGLAAGLKSSVSMDS----------LVSTLPDESAEVRRSHQRHGG 810

  Fly  1007 MGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIES 1071
            ..:.|       |..:..|.::.|.|          :|.....|...|.|         :||::.
Zfish   811 SSQSK-------QDPKRTEGRTELPE----------KQQHKKRSRSFEAS---------KRQVQK 849

  Fly  1072 LEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQS 1136
             .:|||......|.:.|    ...:..:|..:.|    |.|.|.:|:  ...||.:|..::....
Zfish   850 -PRQNASRYPALESISD----NHLVRPALNIIQP----LNGGPANPA--TPPVAKVKIPVSHFTG 903

  Fly  1137 QVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKL 1201
            :|...|.|:..                           :....:.:...|||:.|.:..|  |:.
Zfish   904 EVQFQKLEIRG---------------------------TPPSTIHQKHSDTKRAQAVYKR--QRG 939

  Fly  1202 SDDLCLIDQLQKKNAQLVEQYHKAT----ESLSLAD 1233
            ..|:|....|    .|....|.|:|    :..::||
Zfish   940 QGDVCYPSSL----LQQAGNYKKSTNENPKQKAMAD 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	132/342 (39%)
		Motor_domain	8..321	CDD:277568	129/335 (39%)
		Smc	<680..1449	CDD:224117	97/562 (17%)
		TMPIT	779..>867	CDD:285135	12/87 (14%)
		Smc	1042..1910	CDD:224117	38/196 (19%)
si:dkey-26i13.8	XP_001337836.4	KISc	12..356	CDD:214526	132/342 (39%)
si:dkey-26i13.8	XP_001337836.4	KISc_KIP3_like	12..349	CDD:276821	129/335 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910