DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and cenpe

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_001314688.1 Gene:cenpe / 767754 ZFINID:ZDB-GENE-060929-860 Length:2690 Species:Danio rerio


Alignment Length:2724 Identity:675/2724 - (24%)
Similarity:1146/2724 - (42%) Gaps:733/2724 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRP---------CEPGLTSLWQVKERRSIHLAD---SHAEPYVFDYVFDEGASNQEV 59
            |:::||::|||         .||  ..|:...::::||..|   :..:.|.||.||....|..::
Zfish     5 SAVKVCVRVRPLIKREASESSEP--VQLYWRSDKQAIHQLDEDGAQTKSYSFDRVFSAAESTAQL 67

  Fly    60 FDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLL 124
            :..:||.:|.:.::|:|||||||||||||||:||||.|.||||:.||..::|:.|.|..:::|||
Zfish    68 YQDIAKPLVVSAVEGYNGTIFAYGQTSSGKTFTMMGSEHNPGVIPLAMADVFKTIKSFPKKEFLL 132

  Fly   125 RVGYIEIYNEKIYDLL--NKKNQDLKIHESGN--GIVNVNCEECIITSEVDLLRLLCLGNKERTV 185
            ||.|:|||||.:.|||  :.|.:.|:|.| ||  .:...:..|.::||....|..:..|.|.|..
Zfish   133 RVSYMEIYNETVTDLLCDSWKRKPLEIRE-GNYKNVYVADLTEELVTSPEQALSWITKGEKNRHY 196

  Fly   186 GETNMNERSSRSHAIFKIIIESR-KSD----HSDDDAVIQSVLNLVDLAGSERADQTGARGARLK 245
            |:|.||:||||||.||::|:||| :||    .|.|.|:|.|.||||||||:|||.||||.|||.|
Zfish   197 GKTKMNQRSSRSHTIFRMILESRERSDPTAGESADGAIIVSHLNLVDLAGAERASQTGAEGARFK 261

  Fly   246 EGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQS 310
            ||.:||:||..|..|||.||:.:...|.||||||||||||.||||||.|.|||||.|:.::|:.|
Zfish   262 EGCNINRSLFTLGQVIKKLSDESQKGFLNYRDSKLTRILQNSLGGNAKTVIICTITPATVDETVS 326

  Fly   311 TLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAE---------------------- 353
            ||.||:.||:::..|.|.|:..:..:::|...||..||.:|.|                      
Zfish   327 TLQFASAAKRMKNDPHVTEVSDEGALLRRYRNEIVDLKRRLQEVSSVTQTTATERESLCQLLQEK 391

  Fly   354 EERKNENQQKVEHLERQI--------------------------KHDMHKIICGHSLS-DKGQQK 391
            ::.:.|.:.::::|.:.:                          .|.:::.:|...:| .:...|
Zfish   392 DQLQREQEDRIKNLTKLLVTSSNIALIPKVPKRRVTWGGKLLRSAHLLNEDLCSTDMSFAEPYLK 456

  Fly   392 RRRTWCPTASGSHLELAETGTTEDRID--------QFPKVSHLPKPVFFHTSNAGKRWDNIPKTI 448
            :||..|        .||:.|...|..|        :.|.:......:...:|:.|..:.:.|:..
Zfish   457 KRRADC--------SLADVGEDMDEFDSRFDFTAMEEPNMDMEMSSITVRSSSEGSHFLDSPRAS 513

  Fly   449 NIL-------GSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTD 506
            .::       ..|:..|:|..|:|| :.||.    ..:...|:.||..:..|    :.:...|..
Zfish   514 ELMQKVSSLESQLEAETQSKQIAEE-MNAEL----QMKLSHLQNMLEAQSAP----SHEEKNTIS 569

  Fly   507 KIKKEIQDLQ----------------------MFTSLEK------HFEVECEEV-QGLKE--KLA 540
            :::|:::|||                      ....|||      |.:..||.| :.|:|  :|.
Zfish   570 ELEKQMEDLQRRLETEVQERQTAEEKSISLELKVAELEKPSEELLHSQNTCERVKKDLEEAIQLC 634

  Fly   541 E--------VTAQRDNL---------EQESL-AEKERYDALEKEVTSLRADNEAANSKISE---- 583
            |        |.|:||.:         |.||| |||   |:|:||..:|:.|.:|....:.|    
Zfish   635 ETVSFEKDAVIAERDMIKHSLDMTTEELESLKAEK---DSLQKEKDALQKDKDALQKDMEERRDA 696

  Fly   584 -----LEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSS-----KLRVD-DLLSALLEKESTI 637
                 |||:  :.:...|.:|.||.       ..|.:.|.|     ||:.| .|:|:.|:|::.:
Zfish   697 DEFEKLEEE--SKRDYERELEAENS-------RLEKNLKQSEDMIQKLKADLALMSSELQKKTDL 752

  Fly   638 ES----------------LQKSLDNLTRDVLRNSKEGHML---SIAPEQEDIAGDSICNKCEELE 683
            .:                |::|||:.....|...||...|   :|:.::.|:...:...|.|...
Zfish   753 TTELQGFSGKDIVQEVTRLRRSLDDAETLSLETKKEWAFLRSENISLKERDVTLTTDYGKMEAEV 817

  Fly   684 KLIAD-LESKKNSCECDQ--LRLEIVSVRDKLESVESAF------NLASSEIIQKATDCERLSKE 739
            |::.| ||.:|:..:..|  |:.|::...|:...:.:..      ||..:.:::| |.|: |.||
Zfish   818 KMLQDRLEQEKSRFKKMQTDLQKELMGAFDENTKLTALMDGKVPKNLTDNVVLEK-TVCD-LRKE 880

  Fly   740 LSTSQNAFGQLQERYDALD------------------------QQWQAQQAGITTLHEKHEHVQE 780
            |...:.....||.:...|:                        ::..|..:...:::|.|:.:.|
Zfish   881 LDQIREREQSLQSKVSELETLPAKVDELLGQVCVVSEELRSVREERDAVCSAQASVNEAHQRLTE 945

  Fly   781 KYQKLQEEYEQLESRARSASSAEFQRLQ--NDNT-------------------------KFQADI 818
            .|...|.:..|:||....|...|.|..|  :|||                         :..||:
Zfish   946 DYSTAQHQLLQMESDLLEAQLKETQLSQELSDNTQQLHNMQTENDTLLTSLQEAQQKCEQLSADL 1010

  Fly   819 AS--------LNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKE----LETNFE---EMQR 868
            ||        |:|::|.....|..::|:.|::.:.:.|..|:...::|    |:|:.|   ||..
Zfish  1011 ASVCAERDLLLSEKMEGESEELQSLRNTISSITEEKQQMQEILQSLREQRDQLKTDLEENVEMMI 1075

  Fly   869 EYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQD--INLLHQFV-QLSE 930
            |.........|.|:|   |:.||.:..:..||.           |||::|  ::.|||.: ||:|
Zfish  1076 ETQAELRDAQEKVKE---LQGEINRLESGRVEP-----------DEQREDGQMDTLHQQIKQLTE 1126

  Fly   931 SVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDN----------RQSDATEPIC 985
            .:|...::....:|          |:||...|:..:...:.|:.:          |.||.     
Zfish  1127 ELQATVVEKERLLS----------DRSELMEKMNTDVTSFTEQRSELQERLQQLERDSDT----- 1176

  Fly   986 LKGFLK-------------RHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALME----- 1032
            :|..|:             :.:.|.:.|.|:..|..|||  .|.:.|::...||..|::|     
Zfish  1177 MKTHLEEKEQTILQLQSELQEKQQQQILDQDQQDFSEEK--TDELQQIQTLKEELEAVLEQKNQL 1239

  Fly  1033 -----------------------------ATEATINEMREQMT-----------NLESALLE--- 1054
                                         :.:|:::|..:::|           .:||.|||   
Zfish  1240 TLRLEESAQQVCVVSEELRSVREERDAVCSAQASVSEAHQRLTVDYSTAQHQLLQMESDLLEAQL 1304

  Fly  1055 -KSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPS 1118
             ::.:..::.|..:|:.:::.:|..:....:|.|.:.   ..:|..|..|..:.|.|  ......
Zfish  1305 KETQLSQELSDNTQQLHNMQTENDTLLTSLQETQQKC---EQLSADLASVCAERDLL--LSEKME 1364

  Fly  1119 RREQEVATLK---TSITE-----------LQSQVSDLKAELENH---LRQIQLKDG--------- 1157
            ...:|:.:|:   :||||           |:.|...|||:||:.   |.|.||:.|         
Zfish  1365 GESEELQSLRNTISSITEEKQQMQEILQSLREQRDQLKADLEDSNGMLMQAQLEHGGPQIDTPHD 1429

  Fly  1158 ----NIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQ------ 1212
                .|.:|:.:.:..:|....::..|.|..|.|.:.||.|.....|:.|....:::||      
Zfish  1430 ELLQQIQQLREELDATNEEKNQLKSDLQENVEMTIENQEELRAALDKVKDLQKSLEELQTKQQES 1494

  Fly  1213 KKNAQLVEQYHKATESLS---------LADAKPDQILLSSQYDSQI-------EKLNQLLNAAKD 1261
            |..:||..|..:..|.|.         |::..|:....:.|..:.|       |:|.:.|...:|
Zfish  1495 KHKSQLELQMQQLREELESVRHERERLLSEHSPNTHTDAEQMKADITSLTEEQEQLQRTLQELRD 1559

  Fly  1262 EL----HDVRRIKDD-EISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEK---- 1317
            :|    ..|.:::.| |......|.||...:.:.|...|....|.|.:|..:..|.:|.::    
Zfish  1560 QLMQTEQTVLQLRADLESVCAERERLLMDRSRDVEEMEKMSCRLTEERDALQQTVQQLSDQSEQL 1624

  Fly  1318 ----------LLQVEETLSSVTVRCQAELEAL---KSAHKENISQAVEERNNLIVQHQAEMETIR 1369
                      :||:...|.||   | ||.|.|   ||:..||:|..:.|..:.:.|...:::...
Zfish  1625 RRDLEENQDMVLQLRADLQSV---C-AERERLLTEKSSDMENLSCRLTEERDALQQTVQQLKDQS 1685

  Fly  1370 ETLKNKLAE---------ASTQQSKME--------DAFRAEINEVRATLMEQLNQTKEDRDKGAS 1417
            |.|:..|.|         |..:....|        |...|.|.:.|..|::.|...:|::::..:
Zfish  1686 EQLRRDLEENQDMVLQLRADVESGCAERERLLTERDQDLASITKEREQLLDLLKANREEKNQLRT 1750

  Fly  1418 KLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTR 1482
            .|||.::.|..:..          |||...||:|..|::::::..|..::...|:|:|...::.|
Zfish  1751 DLEENQENLLHLRQ----------ELESVSAEKDHLVSEMSREQKEHLEEMKTTEEKLSAVTVER 1805

  Fly  1483 DQISFEIEAHIKKLELIVASSKKRIIELEEKC---DQQVLELDK---CRL--------------- 1526
            ||:   :|::.:..:.||    :...:|:..|   |..::|.|:   |..               
Zfish  1806 DQL---MESNTEHNQTIV----QLRADLQSACAERDSLMVERDQSSSCSALSDGGDLQEILQGVR 1863

  Fly  1527 EKLSLESEIQKANSEHS----------CTMEKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKI 1581
            |.:.::.|:::...:||          ..:::||.|..||:.|.|.....:.|.|....|     
Zfish  1864 ELIQVQGELKQKKHQHSDPLSPTHKQKAQLQQLQSLTTEMESLRNERMVLRKDLEDAAAT----- 1923

  Fly  1582 TDLEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKVMSLHTELIDSQKGISSRDVE 1646
               .::.:|..|  :..::|..|.:.....:.:::...:.||:::..|:.:|...:......|.|
Zfish  1924 ---SKMYQELLH--VSKEELKQQQKENTELMEQSSARETQLQQQLNELNEDLTALKVLRDQHDTE 1983

  Fly  1647 INELREEL------KAAMDAKATASAEQM-----TLVTQLK--DVEERMANQAEKFTREAANLKG 1698
            |..|:.||      |..:..|:.|..|.:     ||..||:  ..|:.:.:..|:..:....|:|
Zfish  1984 IQRLQSELRSLSREKEDLLEKSRAEGELLRRDLQTLQDQLEKSPTEQLLQSLTEERDQLRRELQG 2048

  Fly  1699 SINELL---LKLNSMQETKDMLESGNEELKEQLRN-------SQNLRNMLDEESKMCI--SLKEK 1751
            .:.:|.   .|...:::.|.:|||....|.:.|..       .||     :.:||..|  .::..
Zfish  2049 KMEKLTHIETKAEQLEKQKILLESEVHSLSQSLSEVNCSVSPDQN-----NTQSKHLIMAGIETS 2108

  Fly  1752 LVKLEDAKTSLEQ-------QLRD-NK-------------------------------------- 1770
            ..||:.|.|.|:|       ||.| |:                                      
Zfish  2109 EEKLQTAFTKLQQIMERPVDQLSDVNREEWAVLYQLVPFIPKERRTINATHTKKTTRLNHAIIKI 2173

  Fly  1771 SEIYQR-----HTELTKEVE-----LGRNRIGEL-----TKKCEELCSDLENSDQIRLDLQETKE 1820
            :|.|||     ||....|::     ...:|:.:|     ....:.|||       ::.|.|:..|
Zfish  2174 AEAYQRLAHRFHTHFQTELQRDVCCFQESRLQDLLLCISPAPSQSLCS-------LQDDFQQLWE 2231

  Fly  1821 Q-LKKTLENNLGWQQKVDEVTRECEK--LRF-DMQSKEVQNESKVQELISECEELRSTLKSKEAS 1881
            | |...||....:.||::.|....|:  .|: :|.|:|.|:.::      |.:||::.|:|..|.
Zfish  2232 QRLSHLLEKRQQYLQKLECVLVVLEEGLSRYAEMLSEERQHRTE------ELQELKTLLRSAHAD 2290

  Fly  1882 FQSEKESMDRTISSLLEDKRNLEEKLCSANDIVAKLETEIAALRPRKSLDRNPVPRKSITFESEI 1946
                      .:..|||.:.:..:|...      :|.|....|..:...:.||:  ||.:.|||.
Zfish  2291 ----------AVIELLERQISRRDKAAE------RLNTYYFVLLNKCDSEINPL--KSSSSESER 2337

  Fly  1947 RKNRRISVHDERRQSYWNDVREFGIM----TDPVDNNCNCAELNSKLQDCQRELFIRESQVTALK 2007
            |      :.|:|||:......:.|.:    .:.:.:|   ..|:.:||...|.:...:.|:..|:
Zfish  2338 R------LEDQRRQTLTLLKAQNGTLPKTEAELLQDN---QHLSQQLQQAHRHVEEIQEQMKELQ 2393

  Fly  2008 MELD------HHPLKDENAQLTKRVIEEQDKAKVEQKRLKMKLQDLNARINDLTTASAKEPESNQ 2066
            ::.|      |..|::...||            :|::.|...|:| ..|.::....|:..|.:::
Zfish  2394 VQADASNQKQHEDLQELRVQL------------MEKQNLVQSLED-KLRHSEALVKSSMTPAASE 2445

  Fly  2067 MAQAAKPATVAAQTQTESDLETILEKTN--VKYQEAVRMLRYRYHLIQELKEKLRQNENSDTSNI 2129
            :| |.|...|      :.:||.|...|:  .:..:...||.:|..:|::|||.||:.:..|..:.
Zfish  2446 LA-ALKDKLV------KMELEHIAVTTSHEKEISQMSSMLEHRGDVIRKLKETLRKQQQDDEQSF 2503

  Fly  2130 T-------SLSAGQTSALK-----------AQCES----QKKEILAIK---YKYEAAKR 2163
            |       ..|:..|:.||           ||.||    |::||...|   ||.:.:||
Zfish  2504 TDGDEFELKTSSRATTTLKEKKMEDLQKKNAQFESLVSKQQEEISKWKRRAYKMKESKR 2562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 166/340 (49%)
Motor_domain 8..321 CDD:277568 165/333 (50%)
Smc <680..1449 CDD:224117 215/1009 (21%)
TMPIT 779..>867 CDD:285135 30/129 (23%)
Smc 1042..1910 CDD:224117 234/1094 (21%)
cenpeNP_001314688.1 KISc 6..343 CDD:214526 166/339 (49%)
KISc_CENP_E 6..337 CDD:276825 165/333 (50%)
Myosin_tail_1 801..1826 CDD:279860 231/1083 (21%)
CASP_C 984..>1100 CDD:285395 25/118 (21%)
DUF342 <1430..1517 CDD:302792 20/86 (23%)
SMC_prok_B 1468..2193 CDD:274008 161/760 (21%)
GluZincin 1935..>2053 CDD:301352 24/117 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170573539
Domainoid 1 1.000 274 1.000 Domainoid score I1739
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 470 1.000 Inparanoid score I1478
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm26081
orthoMCL 1 0.900 - - OOG6_101662
Panther 1 1.100 - - LDO PTHR47968
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5166
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.880

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