Protein Alignment cmet and Kif27

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_780423.2
• Gene: Kif27 / 75050
• MGIID: 1922300
• Length: 1394
• Species: Mus musculus
• Alignment Length: 1582
• Identity: 364/1582 - (23%)
• Similarity: 632/1582 - (39%)
• Gaps: 402/1582 - (25%)

  Fly     9 IQVCIKVRP--CEPGLTSLWQVKERRSIHLAD---------SHAEPYVFDYVFDEGASNQEVFDR 62
            |:|.:::||  |:       :|.....:.:.|         .....:.||:||.:.::..||::.
Mouse     6 IKVAVRIRPLLCK-------EVLHNHQVCVRDIPNTQQIIIGRDRVFTFDFVFGKNSTQDEVYNT 63

  Fly    63 MAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGD------EQNPGVMVLAAKEIFQQISSETERD 121
            ..|.:|.:.::|:|.|:||||||.||||||:.|.      |...|::..|.:||||.||.....|
Mouse    64 CIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVEGQKGIIPRAIQEIFQSISENPSID 128

  Fly   122 FLLRVGYIEIYNEKIYDLLNKKN--QDLKIH--ESGNGIVNVNCEECIITSEVDLLRLLCLGNKE 182
            |.::|.|||:|.|.:.|||..:.  :||.|.  |.||.:: |..:||.:.|..|::.||.:||..
Mouse   129 FKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVI-VGAKECQVESVEDVMSLLQVGNAA 192

  Fly   183 RTVGETNMNERSSRSHAIFKI-IIESRKSDHSDDDAV------IQSVLNLVDLAGSERADQTGAR 240
            |..|.|.|||.||||||||.| :.:..|:..:.::..      |.|..:.||||||||..:||..
Mouse   193 RHTGTTQMNEHSSRSHAIFTISVCQVEKNAEAAENGEWYSHRHIVSKFHFVDLAGSERVTKTGNT 257

  Fly   241 GARLKEGGHINKSLLFLSNVIKSLSE-NADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSI 304
            |.|.||...||..||.|.|||.:|.: ...:....|||:|:||:|:.||||:|.|.:|..:.||.
Mouse   258 GERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSS 322

  Fly   305 --MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEER--KNENQQKVE 365
              .:||.::|.:|.||:.||.||.:| :...|..|..:|.|||:|::.|...:.  ...:|...|
Mouse   323 SDFDESLNSLKYANRARNIRNKPALN-ISPQADRMDEMEFEIKLLREALQSHQASISQASQASSE 386

  Fly   366 HLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQ-FPKVSHLPKP 429
            ::.     |.::|   |||.::..|.:.               |....:|.|:| |..:..|...
Mouse   387 NVP-----DQNRI---HSLEEQVAQLQE---------------ECLGYQDCIEQAFAFLVDLKDA 428

  Fly   430 VFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPD 494
            |..:.....|..:...:|..:                            |..||.|:...:.:.:
Mouse   429 VKLNQKQQHKLQEWFSRTQEV----------------------------RKAVLTPLPGNQGIGN 465

  Fly   495 LPLTPKGP--LTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEK 557
            |   .:||  ||..::|:|::..|            |
Mouse   466 L---EEGPQHLTVLQLKRELKKYQ------------C---------------------------- 487

  Fly   558 ERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLR 622
                       :|.||......|..|||| |.|..|.|  |:.....||.|:   ||.|.:.
Mouse   488 -----------ALAADQVVFTQKDLELEE-LRTQVQLM--MQESKGHAVSLK---EAQKVNR--- 532

  Fly   623 VDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIA 687
                    |:.|..||. |..:|.|:.::.:.|     ||:....::..||....:..|.....|
Mouse   533 --------LQNEKIIEQ-QLLVDQLSAELAKRS-----LSVPTSAKESCGDGPDARASEKRPHTA 583

  Fly   688 DLESK-------------KNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERL--- 736
            ..||.             |..|....:.        .|:.|.:.|...|..::....|.:.:
Mouse   584 PFESHWGHYVYIPSRQDFKKVCSSTPVY--------SLDQVFAGFRTRSQMLMGHLEDQDEVLHC 640

  Fly   737 -SKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSAS 800
             ..:.|..:::.||.:.|..:....|..:...:.:|.|                       .|.:
Mouse   641 QFSDNSDDEDSEGQEKPRVRSRSHSWAKKPGSVCSLVE-----------------------LSDT 682

  Fly   801 SAEFQR--LQNDNTKFQADIASLNERLEEAQNM-LTEVQNSESTVEKLRIQNHELTAKIKELE-- 860
            .||.||  |.|.:.|.        |.|:|:|.: |.:::.||..:.|.:.:..|||..|:..|
Mouse   683 QAESQRSYLGNGDLKM--------ESLQESQEINLQKLRTSELILNKAKQKMRELTINIRMKEDL 739

  Fly   861 --------TNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGIS-------- 909
                    .|.:.:.|:|.....:|     |::|.:.:::...|....:.:.|..:|
Mouse   740 IKELIKTGNNAKSVSRQYSLKVTKL-----EHEAEQAKVELTETRKQLQELESKDLSDVALKVKL 799

  Fly   910 -----SDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAE 969
                 ...|..|..:.:|.:..|.|:.:..:.:|:....|.|    :..:|.
Mouse   800 QKEFRKKMDAAKMRVQVLQKKQQDSKKLASLSIQNEKRASEL----EHNVDH------------- 847

  Fly   970 YIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDI-ISQLEQEIEE---KSAL 1030
                                ||..:.|::|..:|.   ||:|:.||. |.:.:|:|:|   |:..
Mouse   848 --------------------LKYQKVQLQRRLREE---GEKKKQLDAEIKRDQQKIKELQLKAGQ 889

  Fly  1031 MEATEATINEMREQMTNLESALLEKSVIINKVEDYQR----QIESLEKQNAEMTMVYEELQDRVT 1091
            .|.......:......|...:.........|:::.::    ::|.:..|..|:.|:.|:|:.|
Mouse   890 GEGLNPKAEDQDGFNLNRRKSPFRSGDQFQKLDEQRKWLDEEVEKVLSQRQELEMLEEDLKKR-- 952

  Fly  1092 RESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKD 1156
                                          :.:.:.|.::.:.:|.:.:.|......|....||.
Mouse   953 ------------------------------EAIVSKKEALLQEKSLLENKKLRSSQALSTDGLKI 987

  Fly  1157 GNIARLQTDFEEMSERCLSME-------VRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQKK 1214
            .  |||....:|:||:.|.:|       ::::|..:..:::::.|.||...:.:.|.....|..|
Mouse   988 S--ARLNLLDQELSEKSLQLESSPTEEKMKISEQVQALQRERDQLQRQRNSVDERLKHGRVLSPK 1050

  Fly  1215 NAQLVEQYHKATESLSLA-DAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALR 1278
            ...|:.|..:..|:|..| :.|.:.|  .|:.:|.......|..:..:.|..:..:...||.|:.
Mouse  1051 EEHLLFQLEEGIEALEAAIEFKNESI--QSRQNSLKASFQNLSQSEANVLEKLVCLNITEIRAIL 1113

  Fly  1279 MEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLL-------QVEETLSSVTVRCQAEL 1336
            .::..::            ..|:||:.:.:....|:|.|:|       ::|..|..:.::|...|
Mouse  1114 FKYFNKV------------INLRETERKQQLQNKEMKMKVLERDNVVHELESALEHLRLQCDRRL 1166

  Fly  1337 EALKSAHKENISQAVEERNNLIVQH--QAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRA 1399
            ...:..|        |::..|::||  ..:.::|.|||||  .|...||.:.:..|..:.:
Mouse  1167 TLQQKEH--------EQKMQLLLQHFKDQDGDSIIETLKN--YEDKIQQLEKDLYFYKKTS---- 1217

  Fly  1400 TLMEQLNQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIAELEKTKA-EQDLAVNKLTKDNIE 1463
               ..|.:..:|..:||::.:   :||.:..:.|    |.:...|:|.. .::|.....| :|.:
Mouse  1218 ---RDLKKRLKDPAQGAAQWQ---RTLTEHHDAG----DGVLNPEETTVLSEELKWASRT-ENTK 1271

  Fly  1464 L---EKQCSKTQEQLQMESLTR 1482
            |   |::...:...|:.:.||:
Mouse  1272 LNGSEREVDNSSSSLKTQPLTQ 1293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	129/342 (38%)
		SMC_prok_B	539..1431	CDD:274008	180/959 (19%)
		SMC_prok_B	1137..1926	CDD:274008	77/367 (21%)
		YhaN	1717..2182	CDD:443752
Kif27	NP_780423.2	KISc_KIF4	4..342	CDD:276823	129/343 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..582		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..665		4/22 (18%)
		SMC_prok_B	<763..1090	CDD:274008	70/407 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..916		3/29 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1267..1319		7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1325..1344