DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif18b

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_932063.2	Gene:	Kif18b / 70218	MGIID:	2446979	Length:	834	Species:	Mus musculus

Alignment Length:	853	Identity:	226/853 - (26%)
Similarity:	360/853 - (42%)	Gaps:	221/853 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRPCEP-GLTS----LWQVKERR--------------SIHLADSHAEP--------Y 44
            |.::|.::|||..| .|.|    :.||.:.|              .:..:.||..|        :
Mouse     8 SVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSHNGPKKKGKDLTF 72

  Fly    45 VFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKE 109
            |||.||.|.|:.::||.....:|:.:.:||:|.::||||.|.:|||:||:|.|..||:|.|...|
Mouse    73 VFDRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGREGEPGIMYLTTME 137

  Fly   110 IFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHES-GNGIVNVNCEECIITSEVDL 172
            :::::.: :.|:.|.:.:.|:|:|||:|:|||..|. .|.|.|. ..|:|..........|...|
Mouse   138 LYRRLEARQEEKQFEVLISYLEVYNEQIHDLLEPKG-PLTIREDPDKGVVVPGLSFHQPASAEQL 201

  Fly   173 LRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQT 237
            |.:|..||..||...|:.|..||||||||:|.::.:........|:..:.::|:||||||||..|
Mouse   202 LEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAKMSLIDLAGSERASST 266

  Fly   238 GARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTI 300
            .|:|.||:||.:||:|||.|.||:.:|:: |..|.::  ||||||||:|:.|:|||..|.:|..|
Mouse   267 HAKGERLREGANINRSLLALINVLNALAD-AKGRKSHVPYRDSKLTRLLKDSIGGNCRTVMIAAI 330

  Fly   301 KPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSD------ATMMKRLEREIKVLKDKLAEEERK 357
            .||.:  |::.:||.:|.|||:||:..:.|.:..|      ||:.::|:.|:..|::||...|
Mouse   331 SPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQQLQAEVAFLREKLQMYE-- 393

  Fly   358 NENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPK 422
                ...:.|::|.......:....|||....|..     |::..|.||.
Mouse   394 ----AGAQALQQQCSPQPPTLSIPQSLSSSSLQPG-----PSSQSSTLEC--------------- 434

  Fly   423 VSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTE--SNSISEEFLPAECIDFGSPRPDVLKP 485
                      |..|...:.::       |||...|.|  ..|.||:   .:|     |:.   |.
Mouse   435 ----------HAKNETLQEES-------LGSDAQGQEIVEESASEQ---EQC-----PQD---KQ 471

  Fly   486 MLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLE 550
            ..|.:..|:||.:|.                             ..||. |....:.:.|:.:.:
Mouse   472 CPTQKPEPNLPGSPS-----------------------------PSVQA-KPGTGQHSPQKQDAD 506

  Fly   551 QESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAH 615
            .......:.....:::.:.|:|.|......|||.|    ||:|.:....|:::.        |:.
Mouse   507 HSKQLALQVLRLAQRQYSLLQAANLLTPDMISEFE----TLQQLVLEESVDHRA--------ESP 559

  Fly   616 KKSSKLRVDDLLSALLEKEST-------IESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGD 673
            :..:..|.|.|..||..:..:       ..::.|.|:.||          |.|. ||...|...|
Mouse   560 RSPALARGDPLAQALCSESKSSGYCGPVTRTMAKQLNGLT----------HTLG-APLAPDCTSD 613

  Fly   674 SICNK--CEELEKLIAD---------LESKKN-----SC----------ECDQLR---------- 702
            ....|  .|:..||..:         ||.|:.     .|          .|.:.|
Mouse   614 KTFQKPTKEKKRKLTPEEPGSLPAPNLEMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKRERASSP 678

  Fly   703 --------LEIVSVRDKL----------------ESVESAFNLA----SSEIIQKATDCERLSKE 739
                    ..::..|..|                ..:.:.||::    |....|:..|.|::|.|
Mouse   679 SPSSRVCPATVIKSRVPLGPSALQNCSTPLALPTRDLNTTFNVSEESPSKPSFQEFVDWEKVSPE 743

  Fly   740 LSTSQNAF 747
            |:::...|
Mouse   744 LNSTDQPF 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	134/352 (38%)
		Motor_domain	8..321	CDD:277568	132/345 (38%)
		Smc	<680..1449	CDD:224117	21/130 (16%)
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Kif18b	NP_932063.2	KISc_KIP3_like	18..353	CDD:276821	129/336 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..508		31/185 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..642		10/40 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	619..627		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..686		2/30 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810