DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and KIF13A

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_071396.4 Gene:KIF13A / 63971 HGNCID:14566 Length:1805 Species:Homo sapiens


Alignment Length:2194 Identity:480/2194 - (21%)
Similarity:815/2194 - (37%) Gaps:691/2194 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSIHLADS------------HAEP-------------YVF 46
            :.::|.::|||           ..||.:.|...            |..|             :.|
Human     4 TKVKVAVRVRP-----------MNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAF 57

  Fly    47 DYVF---DEG-----ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
            ||.|   ||.     |..:.||..:.:.|:....||:|..|||||||.|||:::|||..:..|::
Human    58 DYCFWSMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLI 122

  Fly   104 VLAAKEIFQQISSE--TERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESG------NGIVN 158
            ......:|::||.|  ..:.|.:.|.|:||||||:.|||:.|  .|.||:.|..      :|:  
Human   123 PRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL-- 185

  Fly   159 VNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD-HSDDDAVIQSV 222
               .:..:||..|:..|:..|||.|||..|||||.||||||:|.|||.....| .|.:.....|.
Human   186 ---SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSK 247

  Fly   223 LNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENA----DNRFTNYRDSKLTRI 283
            ::|||||||||..:|||.|.|||||.:|||||..|..||.||::.|    .::|..||||.||.:
Human   248 VSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPYRDSVLTWL 312

  Fly   284 LQASLGGNAFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKV 346
            |:.:||||:.||:|.||.|:.  .||:.|||.:|.|||:|.....||| ..:|.:::.|..|::.
Human   313 LKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPNAKVIRELREEVEK 376

  Fly   347 LKDKLAEEE--RKNENQQKVEHLERQIK-------HDMHKIICGHSLSDKGQQKRRRTWCPTASG 402
            |:::|::.|  :..|.::|:|..|:.||       ..:.|       :::..|:|:|..  .:.|
Human   377 LREQLSQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRK-------TEEIAQERQRQL--ESMG 432

  Fly   403 SHLELAETGTTEDR-----IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNS 462
            ..||::.....:|:     ::..|.::.|   :.::..:..:...:..:.|.:.|   ||.:   
Human   433 ISLEMSGIKVGDDKCYLVNLNADPALNEL---LVYYLKDHTRVGADTSQDIQLFG---IGIQ--- 488

  Fly   463 ISEEFLPAEC-IDFGSPRPDVLKPMLTIRQLPDLPLTPK--------GPLTTDKIKKEIQDLQMF 518
                  |..| ||..|.              .|:.||||        |.|.....:....|..::
Human   489 ------PQHCEIDIASD--------------GDVTLTPKENARSCVNGTLVCSTTQLWHGDRILW 533

  Fly   519 TSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDAL---EKEVTSLRADNEAANSK 580
            .:  .||                        .:.:|.:::|.|.|   |||......|.:||:..
Human   534 GN--NHF------------------------FRINLPKRKRRDWLKDFEKETGPPEHDLDAASEA 572

  Fly   581 ISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLD 645
            .||.:                      ..:||                      :.:|.:.|:|:
Human   573 SSEPD----------------------YNYEF----------------------AQMEVIMKTLN 593

  Fly   646 NLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRD 710
                                     :.|.:.|..:.|||..  ||.|:::.|..:|..|      
Human   594 -------------------------SNDPVQNVVQVLEKQY--LEEKRSALEEQRLMYE------ 625

  Fly   711 KLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKH 775
                                .:.|:|.::||..:                 |.|.:|...|....
Human   626 --------------------RELEQLRQQLSPDR-----------------QPQSSGPDRLAYSS 653

  Fly   776 EHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSES 840
            :..|:|..:..||.::|                     |:..:|.|.|:|.:|..::.|......
Human   654 QTAQQKVTQWAEERDEL---------------------FRQSLAKLREQLVKANTLVREANFLAE 697

  Fly   841 TVEKLRIQNHELTAKI--KELETNFE----------EMQRE--------YDCLSNQLMESVQEND 885
            .:.||  .::::|.:|  ..|..|.:          :::|:        .:.|.|:|::...   
Human   698 EMSKL--TDYQVTLQIPAANLSANRKRGAIVSEPAIQVRRKGKSTQVWTIEKLENKLIDMRD--- 757

  Fly   886 ALREEIKQRPTSHVEESMRSSGISSD-FDEQKQDINLL---HQF-------VQLSESVQQIELQH 939
             |.:|.|::    |.|:.|..|...| |.|.:::.||:   :.|       |:|..:|..|..| 
Human   758 -LYQEWKEK----VPEAKRLYGKRGDPFYEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQ- 816

  Fly   940 HSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEH 1004
             ..::.......|::..:.|         |.:.||:...:::|    .|            |.|.
Human   817 -GEVAGRLHVEVMRVTGAVP---------ERVVEDDSSENSSE----SG------------SLEV 855

  Fly  1005 VDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLE-----KSVIINKVED 1064
            ||...|  ::..:.:|...::.|    |||...:|     ::|.......     :|.:...|.|
Human   856 VDSSGE--IIHRVKKLTCRVKIK----EATGLPLN-----LSNFVFCQYTFWDQCESTVAAPVVD 909

  Fly  1065 YQRQIESLEKQNAEMTMVYEELQD---RVTRE--SSMSESLLRVPP-------------DEDTLP 1111
              .::.|.:.::|:.|:.:...:|   .||.|  ..:|:..|.:..             :.|:|.
Human   910 --PEVPSPQSKDAQYTVTFSHCKDYVVNVTEEFLEFISDGALAIEVWGHRCAGNGSSIWEVDSLH 972

  Fly  1112 GCPTSPSRREQEVA---TLKTSITELQSQVSDLKAELENHLRQ-------IQLKDGNIARLQTDF 1166
            ....:...|..||.   .:..||.|| :::.:. |.:|.|..:       .||:.|:..|:|...
Human   973 AKTRTLHDRWNEVTRRIEMWISILEL-NELGEY-AAVELHQAKDVNTGGIFQLRQGHSRRVQVTV 1035

  Fly  1167 EE---------MSERCLSMEV-----RLAEL---------------DEDTKQKQEL--------- 1193
            :.         |.|..||:.:     |..:|               |.|:.|:::|         
Human  1036 KPVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQRDDEDGDDMDSYQEEDLNCVRERWSD 1100

  Fly  1194 --------LDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLA---------DAKPDQILL 1241
                    ||.|.:|:|:.....:...::.||||||:...||..:..         ...|...:.
Human  1101 ALIKRREYLDEQIKKVSNKTEKTEDDVEREAQLVEQWVGLTEERNAVLVPAPGSGIPGAPADWIP 1165

  Fly  1242 SSQYDSQIEKLNQLLNA----AKDEL---------------H-------DVRRIKDDEISA---- 1276
            ....::.|..|...|||    |.::|               |       .:.:..|||:||    
Human  1166 PPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATASW 1230

  Fly  1277 ---------------------------------LRMEFLLQIETNEKENQAKFYAE---LQETKD 1305
                                             ..||.:|:     |...|..|.:   .|..|.
Human  1231 DSSVHDSVHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLR-----KRIAANIYNKQSFTQSLKR 1290

  Fly  1306 R-------------YE--SNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERN 1355
            |             ||  ||:.:..|: ::..|||:.:..|.:.|..:....:.|..::.|.:..
Human  1291 RISLKNIFYSCGVTYEIVSNIPKATEE-IEDRETLALLAARSENEGTSDGETYIEKYTRGVLQVE 1354

  Fly  1356 NLI-VQHQAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKG--AS 1417
            |:: ::...:..|::|.|..|........|      ...::.|.:: ...|:...|| |||  .:
Human  1355 NILSLERLRQAVTVKEALSTKARHIRRSLS------TPNVHNVSSS-RPDLSGFDED-DKGWPEN 1411

  Fly  1418 KLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLA-VNKLTKDNIELEKQ-C-SKTQEQLQMES 1479
            :|:               |||      .:.:.||:| ...|.:|:....|: | |:|...|.:..
Human  1412 QLD---------------MSD------YSSSYQDVACYGTLPRDSPRRNKEGCTSETPHALTVSP 1455

  Fly  1480 LTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSC 1544
            .  ...|.:.....|.|..:....||| |.||.:             ..||.||..........|
Human  1456 F--KAFSPQPPKFFKPLMPVKEEHKKR-IALEAR-------------PLLSQESMPPPQAHNPGC 1504

  Fly  1545 TMEKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLK 1609
            .:..... .:.|.|..|...::|.|.|.:           |..|:....|      |:|....:.
Human  1505 IVPSGSN-GSSMPVEHNSKREKKIDSEEE-----------ENELEAINRK------LISSQPYVP 1551

  Fly  1610 ICLAEANELSSNLQ-KKVMSLHTELIDSQKGISSRDVEINELREELKAAMDAKATASAEQMTLVT 1673
            :..|:.:..:::|: ::..|...:|.:|:  :..::|..:.....:.:...:.:.::|....:|.
Human  1552 VEFADFSVYNASLENREWFSSKVDLSNSR--VLEKEVSRSPTTSSITSGYFSHSASNATLSDMVV 1614

  Fly  1674 QLKDVEERMANQAEKFTREAANLKGSINELLLKLNSMQETKDMLESGNEELKEQLRNSQNLRNML 1738
            ...|..:::|.|    |::|.:.:.|...|:         .|...|.|:||.|       :...|
Human  1615 PSSDSSDQLAIQ----TKDADSTEHSTPSLV---------HDFRPSSNKELTE-------VEKGL 1659

  Fly  1739 DEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVELGRNRIGELTKKCEEL-- 1801
            .::..:.:.|||.....:.:.:|  |.:.:..|:...|                  |..|.||  
Human  1660 VKDKIIVVPLKENSALAKGSPSS--QSIPEKNSKSLCR------------------TGSCSELDA 1704

  Fly  1802 C-SDLENSDQIRLDLQETKEQLKKTLENNLGWQQKVDEVTRECEKLRFDMQSKEVQNESKVQELI 1865
            | |.:....:.....:.|.|.....||::     ...|.....|...||..:     :|...||.
Human  1705 CPSKISQPARGFCPREVTVEHTTNILEDH-----SFTEFMGVSEGKDFDGLT-----DSSAGELS 1759

  Fly  1866 SECEELRSTLKSKEASFQSEKESMDRTISSLLEDKRNLEEKLCSANDIV 1914
            |     |.:|.:|...         :|:|..|.....|..||  .||.|
Human  1760 S-----RRSLPNKTGG---------KTVSDGLHHPSQLHSKL--ENDQV 1792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 143/369 (39%)
Motor_domain 8..321 CDD:277568 142/362 (39%)
Smc <680..1449 CDD:224117 180/971 (19%)
TMPIT 779..>867 CDD:285135 18/99 (18%)
Smc 1042..1910 CDD:224117 196/1046 (19%)
KIF13ANP_071396.4 KISc_KIF1A_KIF1B 5..359 CDD:276816 143/369 (39%)
Kinesin_assoc 356..468 CDD:318424 25/124 (20%)
FHA 446..543 CDD:238017 21/151 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 6/18 (33%)
SMC_N <606..771 CDD:330553 43/240 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..656 6/39 (15%)
KIF1B 748..792 CDD:315155 15/51 (29%)
DUF3694 <1215..1279 CDD:315198 10/68 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1385..1404 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1531 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1612..1645 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1749..1779 10/48 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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